F-18 FDG PET Images of Uterine Cervical Cancer Producing Granulocyte Colony Stimulating Factor

Koyama, Masamichi; Hayasaka, Kazumasa; Takeshima, Nobuhiro; Machida, Hiroko; Takizawa, Ken

doi:10.1097/rlu.0b013e3181f4a00c

Cited by 5 publications

(1 citation statement)

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“…Increased FDG uptake in the spleen was described in 8 of the 10 cases in which splenic uptake was evaluated [ 7 , 11 , 20 , 22 , 26 ]. On FDG-PET/CT, splenic uptake is normally less than hepatic uptake [ 56 , 57 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Imaging findings of granulocyte colony-stimulating factor-producing tumors: a case series and review of the literature

et al. 2021

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Granulocyte colony-stimulating factor (G-CSF)-producing tumors have an aggressive clinical course. Here, we report five cases of G-CSF-producing tumors and review the literature, focusing on imaging findings related to tumor-produced G-CSF. In addition to our cases, we identified 30 previous reports of G-CSF-producing tumors on which 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT, bone scintigraphy, or evaluation of bone marrow MR findings was performed. White blood cell count, serum C-reactive protein, and serum interleukin-6 were elevated in all cases for which these parameters were measured. G-CSF-producing tumors presented large necrotic masses (mean diameter 83.2 mm, range 17–195 mm) with marked FDG uptake (mean maximum standardized uptake value: 20.09). Diffuse FDG uptake into the bone marrow was shown in 28 of the 31 cases in which FDG-PET/CT was performed. The signal intensity of bone marrow suggested marrow reconversion in all seven MRI-assessable cases. Bone scintigraphy demonstrated no significant uptake, except in two cases with bone metastases. Splenic FDG uptake was increased in 8 of 10 cases in which it was evaluated. These imaging findings may reflect the effects of tumor-produced G-CSF. The presence of G-CSF-producing tumors should be considered in patients with cancer who show these imaging findings and marked inflammatory features of unknown origin.

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Section: Literature Reviewmentioning

confidence: 99%

Imaging findings of granulocyte colony-stimulating factor-producing tumors: a case series and review of the literature

et al. 2021

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2011

Current Opinion in Oncology

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How we treat elderly patients with Hodgkin lymphoma Review: (pp. 421-428) Advani RH, Chen HY, Habermann TM, Morrison VA, et al. Comparison of conventional prognostic indices in patients older than 60 years with diffuse large B-cell lymphoma treated with R-CHOP in the US Intergroup Study (ECOG 4494, CALGB 9793): consideration of age greater than 70 years in an elderly prognostic index (E-IPI). Br J Haematol 2010; 151:143-151. Bö ll B, Gö rgen H, Fuchs M, et al. Feasibility and efficacy of ABVD in elderly Hodgkin lymphoma patients: analysis of two randomized prospective multicenter trials of the German Hodgkin study group (HD10 and HD11). ASH Annual Meeting and Exposition 2010; Abstract No. 418.

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Current World Literature

2012

Current Opinion in Obstetrics &Amp; Gynecology

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F-18 FDG PET Images of Uterine Cervical Cancer Producing Granulocyte Colony Stimulating Factor

Cited by 5 publications

References 9 publications

Imaging findings of granulocyte colony-stimulating factor-producing tumors: a case series and review of the literature

Imaging findings of granulocyte colony-stimulating factor-producing tumors: a case series and review of the literature

Current World Literature

Current World Literature

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