F-18 FDG PET/CT of Polymyalgia Rheumatica

Toriihara, Akira; Seto, Youhei; Yoshida, Katsuya; Umehara, Isao; Nakagawa, Takayuki; Liu, Ren; Iwamoto, Itsuo

doi:10.1097/rlu.0b013e31819e51fd

Cited by 15 publications

(10 citation statements)

References 11 publications

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“…We performed 18-fluorodeoxyglucose-positron emission tomography (FDG-PET)/ computed tomography (CT) (PET) in patients with PMR and observed multiple abnormal accumulations of FDG in the major joints of the limbs and their surrounding regions, vertebral joints, and ligament attachment sites, suggesting that inflammation of the ligament attachment sites is another pathology of PMR, in addition to that of synovitis. To date, only a limited number of recent reports on PET findings of PMR exist [3,4]. Here, we compare the findings in our patients with those of previously reported cases and discuss the usefulness of PET for the diagnosis of PMR.…”

Section: Introductionmentioning

confidence: 48%

FDG-PET/CT of polymyalgia rheumatica

Kotani¹,

Komori²,

Kanzaki³

et al. 2010

Mod Rheumatol

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Section: Introductionmentioning

confidence: 48%

FDG-PET/CT of polymyalgia rheumatica

Kotani¹,

Komori²,

Kanzaki³

et al. 2010

Mod Rheumatol

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“…In 22 of these 242 cases (9%), the diagnosis PMR was made. The images of the 18 F-FDG PET(/CT) scan in these patients revealed a characteristic pattern of pathological 18 F-FDG uptake in the soft tissues and ligaments (perisynovitis or enthesitis) around the shoulders, lumbar spinous processes, and ischial tuberosities [50,51]. As GCA and PMR may occur together, 18 F-FDG PET/(CT) may diagnose patients with PMR or GCA as an isolated condition, which is clinically relevant as GCA patients are more prone to develop thoracic aortic dilatation and therefore need more monitoring [52].…”

Section: Discussionmentioning

confidence: 98%

Parameters related to a positive test result for FDG PET(/CT) for large vessel vasculitis: a multicenter retrospective study

et al. 2012

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The purpose of this study was to identify clinical and laboratory parameters that may improve the effectiveness of the use of fluorodeoxyglucose positron emission tomography ((18)F-FDG PET)(/CT) for diagnosing large vessel vasculitis (LVV), and secondarily to assess the contribution of (18)F-FDG PET/CT in finding other diagnoses for patients without signs of LVV on the scan. A multicenter retrospective study of (18)F-FDG PET(/CT) scans performed between January 2000 and December 2009 for clinical suspicion of LVV was conducted. A total of 304 (18)F-FDG PET(/CT) scans were included, of which 62 (20%) were positive and 242 (80%) were negative for LVV. Univariate analysis showed that patients with a positive scan were older (65.9 ± 13.4 versus 58.6 ± 16.5 years, p = 0.002), were more frequently female (76% versus 55%, p = 0.002), more often had a history of temporal arteritis (10% versus 3%, p = 0.044), less frequently had artralgia (31% versus 67%, p = 0.000), and had higher thrombocyte counts (434 ± 161 versus 373 ± 168 × 10(9)/l, p = 0.049) and a higher erythrocyte sedimentation rate (ESR) (72.6 ± 31.0 versus 51.4 ± 30.5 mm/h, p = 0.001) than patients with a negative scan. In the multivariate analysis, only artralgia (OR 0.091; 95% CI 0.023-0.366) and ESR (OR 1.024; 95% CI 1.002-1.046) remained statistically significant predictors. The presence of artralgia is a statistically significant negative predictor and an elevated ESR a statistically significant positive predictor of LVV showing up on (18)F-FDG PET(/CT). A reliable prediction of the outcome of the scan, based on these two parameters, is not possible however. (18)F-FDG PET(/CT) allows early diagnosis of LVV and may discover occult inflammatory or neoplastic disorders.

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“…3,5) (ref. [33][34][35][36][37][38][39] ). Correlation of cervical interspinous bursitis seen as high-contrast enhancement (MRI) and high FDG uptake (PET/CT) was published in 2012 by two author groups 32,40 .…”

Section: Discussionmentioning

confidence: 99%

Various forms of <sup>18</sup>F-FDG PET and PET/CT findings in patients with polymyalgia rheumatica

Řehák¹,

Vašina²,

Němec³

et al. 2015

BIOMED PAP

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Aim. Polymyalgia rheumatica (PMR) is a disease presenting with pain and stiffness, mainly in shoulders, hip joints and neck. Laboratory markers of inflammation may bolster diagnosis. PMR afflicts patients over 50 years old, predominantly women, and may also accompany giant cell arteritis. Patients and Methods. 67 patients, who fullfiled Healey´s criteria for PMR in the period between 2004 and 2013 and had positive FDG PET (PET/CT) findings were retrospectively evaluated. FDG uptake was assessed in large arteries, proximal joints (shoulders, hips and sternoclavicular joints), in extraarticular synovial structures (interspinous, ischiogluteal and praepubic bursae). Results. Articular/periarticular involvement (A) was detected in 59/67 (88.1%) patients and extrarticular synovial involvement (E) in 51/67 (76.1%) patients either individually or in combinations. Vascular involvement (V) was detected in 27/67 (40.3%) patients only in combination with articular (A) and/or extraarticular synovial (E) involvement. These combinations were: A+E involvement in 30/67 (44.8%) patients, A+V involvement in 8/67 (11.9%) patients, E+V involvement in 6/67 (9%) patients and A+E+V in 13/67 (19.4%) patients. Conclusions. PMR presents by articular/periarticular synovitis, extraarticular synovitis and can be accompanied by giant cell arteritis. All types of involvement have their distinct FDG PET (PET/CT) finding, which can be seen either individually or in any of their 4 combinations. FDG PET (PET/CT) examination seems to be an advantageous one-step examination for detecting different variants of PMR, for assessing extent and severity and also for excluding occult malignancy.

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F-18 FDG PET/CT of Polymyalgia Rheumatica

Cited by 15 publications

References 11 publications

FDG-PET/CT of polymyalgia rheumatica

FDG-PET/CT of polymyalgia rheumatica

Parameters related to a positive test result for FDG PET(/CT) for large vessel vasculitis: a multicenter retrospective study

Various forms of <sup>18</sup>F-FDG PET and PET/CT findings in patients with polymyalgia rheumatica

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