F-18 FDG PET/CT in Giant Cell Arteritis With Polymyalgia Rheumatica

Anjos, Dalton Alexandre dos; Anjos, Renata Fockink dos; Paula, Wagner Diniz de; Sobrinho, Alaor Barra

doi:10.1097/rlu.0b013e318170d46a

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…To our knowledge, the only data on the epidemiology of GCA in the Brazilian population are two case reports and a small study evaluating anterior ischemic optic neuropathy (AION) in GCA patients (7-9). Therefore, this study aimed to describe the demographic features, disease manifestations, therapy and outcomes of Brazilian patients with GCA.…”

Section: Introductionmentioning

confidence: 99%

Giant cell arteritis: a multicenter observational study in Brazil

Souza¹,

Okamoto²,

Abrantes³

et al. 2013

Clinics

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OBJECTIVE:To describe demographic features, disease manifestations and therapy in patients with giant cell arteritis from referral centers in Brazil.METHODS:A retrospective cohort study was performed on 45 giant cell arteritis patients from three university hospitals in Brazil. Diagnoses were based on the American College of Rheumatology classification criteria for giant cell arteritis or temporal artery biopsy findings.RESULTS:Most patients were Caucasian, and females were slightly more predominant. The frequencies of disease manifestations were as follows: temporal headache in 82.2%, neuro-ophthalmologic manifestations in 68.9%, jaw claudication in 48.9%, systemic symptoms in 44.4%, polymyalgia rheumatica in 35.6% and extra-cranial vessel involvement in 17.8% of cases. Aortic aneurysms were observed in 6.6% of patients. A comparison between patients with biopsy-proven giant cell arteritis and those without temporal artery biopsies did not yield significant differences in disease manifestations. All patients were treated with oral prednisone, and intravenous methylprednisolone was administered to nearly half of the patients. Methotrexate was the most commonly used immunosuppressive agent, and low-dose aspirin was prescribed to the majority of patients. Relapses occurred in 28.9% of patients, and aspirin had a protective effect against relapses. Females had higher prevalences of polymyalgia rheumatica, systemic manifestations and jaw claudication, while permanent visual loss was more prevalent in men.CONCLUSIONS:Most of the clinical features of Brazilian giant cell arteritis patients were similar to those found in other studies, except for the high prevalence of neuro-ophthalmic manifestations and permanent blindness in the Brazilian patients. Aspirin had a protective effect on relapses.

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Section: Introductionmentioning

confidence: 99%

Giant cell arteritis: a multicenter observational study in Brazil

Souza¹,

Okamoto²,

Abrantes³

et al. 2013

Clinics

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“…We diagnosed as large-vessel GCA associated with secondary PMR. As previous reports [3][4][5][6][7] , large-vessel arteritis and bursitis/enthesitis in the present case were considered as the findings of GCA and PMR, respectively. Glucocorticoid therapy (prednisolone 40 mg daily) was initiated and induced rapid symptomatic relief after 48 hours, suggesting that it could be considered as diagnostic criterion.…”

Section: Case Presentationmentioning

confidence: 54%

“…New diagnostic imaging methods for GCA and PMR have been sought. Recent several reports showed that FDG-PET/CT scans accurately, and safely identifies the multiple vessel involvements of GCA [3,4] and bursitis lesions of PMR [5][6][7] . A smooth linear or long segmental pattern of FDG uptake in the aorta and its main branches is thought to be a characteristic pattern of GCA [8] , and FDG-PET/CT finding in the present case matched to this finding.…”

Section: Discussionmentioning

confidence: 99%

Clinical implication of FDG-PET/CT in monitoring disease activity in large-vessel giant cell arteritis linked with secondary polymyalgia rheumatica

Taniguchi

Nakayama

Terada

2014

CRIM

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Seventy year-old female presented low-grade fever, neck and pelvic girdle pain, jaw claudication and pulseless without visual disturbance. Laboratory examinations showed that C-reactive protein and erythrocyte sedimentation rate (ESR) were 11 mg/dl and 123 mm/1hr, respectively. FDG-PET/CT findings demonstrated bilateral subclavian, carotid and femoral arteritis and aortitis in addition to bursitis and enthesitis of spinous process and pelvic girdle. We diagnosed as large-vessel giant cell arteritis (GCA) linked with secondary polymyalgia rheumatica (PMR). Glucocorticoid therapy was started, and not only these symptoms and but also abnormal findings of FDG-PET/CT were improved.

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“…Über erste Erfahrungen der PET-CT zur Darstellung einer Riesenzellarteriitis wurde bisher nur in Kasuistiken berichtet [29]. Es liegen somit noch keine ausreichenden Erfahrungen vor, ob mit dieser Methode bei Patienten mit Großgefäßvaskulitiden ein diagnostischer Zugewinn erreicht werden kann.…”

Section: Typische Befunde In Der Fdg-petunclassified

Imaging techniques in the evaluation of primary large vessel vasculitides

et al. 2009

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This article focuses on the clinical application and technical aspects of imaging methods which are used alternatively or additionally to angiography or magnetic resonance imaging in patients with Takayasu's arteritis or giant cell arteritis. Providing a high spatial resolution, duplex ultrasound is particularly suitable for the evaluation of peripheral arteries. With the exception of cranial arteries, positron emission tomography as a whole body examination is the best imaging modality for the assessment of inflammatory activity. Computed tomography is used for angiographic examinations and enables evaluation of wall thickening in large arteries. It is the method of choice in the case of emergencies due to aortic aneurysm or dissection. In addition to angiographic and ultrasound techniques, ophthalmological methods comprise biomicroscopy, including funduscopy and optical coherence tomography.

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F-18 FDG PET/CT in Giant Cell Arteritis With Polymyalgia Rheumatica

Cited by 9 publications

References 7 publications

Giant cell arteritis: a multicenter observational study in Brazil

Giant cell arteritis: a multicenter observational study in Brazil

Clinical implication of FDG-PET/CT in monitoring disease activity in large-vessel giant cell arteritis linked with secondary polymyalgia rheumatica

Imaging techniques in the evaluation of primary large vessel vasculitides

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