F-18 FDG PET/CT imaging of cardiac and vascular inflammation and infection

Lawal, Ismaheel; Sathekge, Mike

doi:10.1093/bmb/ldw035

Cited by 57 publications

(42 citation statements)

References 110 publications

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“…A single study utilising 67 Ga scintigraphy has reported an increased uptake in the RV free wall in patients with ARVC compared to controls [18]. FDG-PET is an established method for assessing myocardial inflammation and is used increasingly in the clinical work-up of patients with clinically suspected myocarditis [19].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of 18F-fluorodeoxyglucose positron emission tomography abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy

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Wicks

Ashworth

et al. 2019

International Journal of Cardiology

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Background Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a heritable heart muscle disease that causes sudden cardiac death in the young. Inflammatory myocardial infiltrates have been described at autopsy and on biopsy, but there are few data on the presence of myocarditis in living patients with ARVC using non-invasive imaging techniques. FDG-PET is a validated technique for detecting myocardial inflammation in clinically suspected myocarditis. We aimed to determine the prevalence of myocardial inflammation in patients with ARVC using 18 Ffluorodeoxyglucose positron emission tomography (FDG-PET). Methods and Results We performed a retrospective analysis of a single centre cohort of patients with ARVC referred for FDG-PET scans between 2012 and 2017 for investigation of symptoms or suspected device infection. Sixteen patients (12 male; age 42±13 years) with a definite diagnosis of ARVC were identified. Seven had positive FDG-PET scans, two of whom had cardiac sarcoidosis on endomyocardial biopsy. Of the remaining five, two carried pathogenic desmoplakin mutations. FDG uptake was found in the left ventricular myocardium in all cases. One patient also had right ventricular uptake. Conclusion In this exploratory study, we show that some patients with ARVC have evidence for myocardial inflammation on FDG-PET, suggesting that myocarditis plays a role in disease pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Prevalence of 18F-fluorodeoxyglucose positron emission tomography abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy

Protonotarios

Wicks

Ashworth

et al. 2019

International Journal of Cardiology

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“…18 F-FDG remains the most commonly used PET tracer in clinical application. Its lack of specificity in differentiating sterile inflammation from infection, however, represents a significant limitation, especially in the postoperative period (8). An unmet need therefore remains in the clinical differentiation of inflammation from infection.…”

Section: Replymentioning

confidence: 99%

Reply: Molecular Imaging of Bacteria in Patients Is an Attractive Fata Morgana, Not a Realistic Option

2018

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“…It is also important to differentiate superficial wound infection from an actual device infection, as the two types of infection are managed differently. Whereas deep infection affecting the device requires removal of the device, with its attendant risk of mortality and morbidity, superficial wound infection requires only local wound care and parenteral antibiotics (11). Clinical assessment is often not sufficient to make this distinction (12).…”

Section: Imaging Cellular Metabolism: 18 F-fdgmentioning

confidence: 99%

Metabolic Imaging of Infection

et al. 2017

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Metabolic imaging has come to occupy a prominent place in the diagnosis and management of microbial infection. Molecular probes available for infection imaging have undergone a rapid evolution starting with nonspecific agents that accumulate similarly in infection, sterile inflammation, and neoplastic tissue and then extending to more targeted probes that seek to identify specific microbial species. This focus review describes the metabolic and molecular imaging techniques currently available for clinical use in infection imaging and those that have demonstrated promising results in preclinical studies with the potential for clinical applications.

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F-18 FDG PET/CT imaging of cardiac and vascular inflammation and infection

Abstract: Larger prospective studies are needed to validate the superiority of F-18 FDG PET/CT imaging over conventional anatomic imaging modalities.

Cited by 57 publications

References 110 publications

Prevalence of 18F-fluorodeoxyglucose positron emission tomography abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy

Prevalence of 18F-fluorodeoxyglucose positron emission tomography abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy

Reply: Molecular Imaging of Bacteria in Patients Is an Attractive Fata Morgana, Not a Realistic Option

Metabolic Imaging of Infection

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