Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients

Non-Cholesterol Sterol Concentrations as Biomarkers for Cholesterol Absorption and Synthesis in Different Metabolic Disorders: A Systematic Review

“…Eleven studies met the inclusion criteria (Table 3). Three studies were performed in patients with Familial Combined Hyperlipidemia (FCH) [54,55,56], one study in patients with Familial Hypercholesterolemia (FH) [57], and four studies included patients with FCH, FH or another (non-FH) form of hypercholesterolemia [58,59,60,61]. Patients with hypercholesterolemia other than FCH of FH were evaluated in three studies [62,63,64].…”

“…In patients diagnosed with hypercholesterolemia other than FCH or FH, at least one of the cholesterol absorption markers increased in three comparisons [58,60,61], was comparable in two comparisons [64], and was not tested or measured in three comparisons [59,62,63]. One study reported higher cholesterol absorption in subjects diagnosed with heterogeneous autosomal dominant hypercholesterolemia compared to normolipidemic control subjects [61].…”

“…For cholesterol synthesis, most comparisons did not find a difference between hypercholesterolemic cases and their controls [60,61,62,64], while cholesterol synthesis was suggested to be higher in one study [61] and lower in another study [58] in cases compared to controls. Two studies measured cholesterol synthesis, but did report differences between cases and control subjects, although it seems that cholesterol synthesis was lower in subjects with hypercholesterolemia [59,63].…”

Assessment of Lipophilic vs. Hydrophilic Statin Therapy in Acute Myocardial Infarction

“…Beneficial effects of ezetimibe have been demonstrated not only on serum oxidized cholesterols 35 or stable long-term reduction in LDL-C, 36 but also on clinical outcome following elective vascular surgery 37 or AMI. 38 Conversely, combined therapy of ezetimibe and simvastatin showed no difference in intima-media thickness as compared with simvastatin alone; 39 moreover, the use of ezetimibe led to a paradoxical increase in the carotid intima-media thickness in association with greater reduction in LDL-C. 40, 41 The present study was not designed to evaluate the efficacy of ezetimibe, but no disadvantage was observed in patients requiring ezetimibe to control high LDL-C under the initial statin therapy.…”

Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)

“…101 Moreover, the level of 27-OHC has been reported to be 5 times lower than that of desmosterol in human plasma. 117,118 The physiological relevance of different sterols thus still seems to be not completely clear and needs further evaluation. 3.1.5 Neoruscogenin.…”