Eyelid Metastasis Originated From Gastric-Cancer

Metastatic gastric carcinoma to the eyelids masquerading as a chalazion: A case report

“…Metastatic gastric adenocarcinoma to the eyelid is a rare entity, with only a dozen reported cases ( Table 1 ). 1 , 12 , 13 , 14 , 16 , 17 , 18 , 19 Eyelid involvement was the initial presentation of metastatic disease in four cases, 1 , 13 , 18 while six cases had a previously known history of gastrointestinal malignancy. 12 , 14 , 15 , 16 , 17 , 19 In two cases, it was not specified whether a prior history of malignancy had been established.…”

“… 1 , 12 , 13 , 14 , 16 , 17 , 18 , 19 Eyelid involvement was the initial presentation of metastatic disease in four cases, 1 , 13 , 18 while six cases had a previously known history of gastrointestinal malignancy. 12 , 14 , 15 , 16 , 17 , 19 In two cases, it was not specified whether a prior history of malignancy had been established. 15 The clinical presentation was variable, ranging from one case of a chalazion-like lesion to other cases presenting as lid ulceration, induration and thickening, painless nodule, and edema of the periocular skin involving the four lids (mask-like).…”

“… Radiotherapy No change in lesion appearance, patient expired (time from diagnosis to death not specified) Riley (1970) 1 Lid ulceration Lid induration and thickening Inoperable metastatic disease Poor, both patients died after metastatic carcinomatosis diagnosed Arnold et al (1985) 13 Solitary, painless lid nodule Surgical excision Patient deceased five months after diagnosis Weiner et al (1986) 14 Enlarging nodule of right upper lid, progressed to complete blepharoptosis. Local resection Patient deceased from metastatic disease two months after eyelid surgery Mansour, Hidayat (1987) 15 Case series (31 cases): three originated from gastrointestinal system with variable presentation (lid nodule, ptosis, woody” lids, diffuse and cystic swelling) Not mentioned Not mentioned Namieno et al (1994) 16 Isolated, nontender mass of right upper lid concurrent with diagnosis of metastatic gastric carcinoma Gastrectomy Patient died from complications of a traffic accident two months after gastrectomy Martorell-Catalayud et al (2010) 17 Four eyelid involvement (firm swelling of the periocular skin and nasolabial folds) in patient with previous diagnosis of metastatic gastric carcinoma Chemotherapy Patient deceased five months after diagnosis Rodriguez Garcia et al (2010) 18 Painless swelling of left upper and lower lid concurrent with diagnosis of signet ring cell carcinoma of stomach Not addressed since rapid deterioration due to metastatic disease Patient deceased several days after diagnosis Won et al (2015) 19 Localized erythematous plaque in eyelid five years after diagnosis of gastric adenocarcinoma Not addressed since rapid deterioration of disease …”

“…To our knowledge, only 12 cases of gastrointestinal metastasis to eyelid have been described in the literature. 1 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 Unveiling the diagnosis can be challenging, especially if an initial tissue biopsy suggests an inflammatory rather than a neoplastic process. We present an atypical case of eyelid metastasis masquerading as a chalazion in a patient with a known history of gastrointestinal adenocarcinoma.…”