Eye tracking – The overlooked method to measure cognition in neurodegeneration?

Bueno, Ana Paula Arantes; Sato, João Ricardo; Hornberger, Michael

doi:10.1016/j.neuropsychologia.2019.107191

Cited by 49 publications

(41 citation statements)

References 136 publications

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“…To this end, humans use a repertoire of functional movements which include saccades with their ballistic dynamics, smooth tracking and small tremors (Rucci & Victor, 2015). These movements have been studied extensively in paradigms which have helped isolate their characteristics and suggested in a range of contexts that the ocular motor system is a useful window into brain function (Bueno, Sato, & Hornberger, 2019;Freedman & Foxe, 2018;Kowler, 2011;Spering & Montagnini, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The biometrics therefore captured participants' unique ocular motor signatures. With a better theoretical understanding of the relationships between the components of such biometrics, the roles played by the separate but interconnected sensorimotor networks of brain regions such as striate and extra-striate visual cortex, middle temporal visual motion area (MT), the frontal eye fields (FEF) and the superior colliculus (SC) in generating finely controlled eye movements might be more distinctly isolated and understood (Bueno et al, 2019;Freedman & Foxe, 2018;Masson & Perrinet, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Evidence of inverted gravity‐driven variation in predictive sensorimotor function

Meso

Vai

Hills

2020

Eur J of Neuroscience

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evidence of inverted gravity‐driven variation in predictive sensorimotor function

Meso

Vai

Hills

2020

Eur J of Neuroscience

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“…The head typically is positioned in a chinrest. Calibration can be challenging for this equipment when trial sessions are long, contact or corrective lenses are used, or there are long eye lashes [14]. Modern videography and computer algorithms can measure parameters using reflections from eye layers and appearance based techniques using facial feature recognition [15].…”

Section: Tracking Methodsmentioning

confidence: 99%

The Role of Eye Tracking Technology in Assessing Older Driver Safety

Carr

Grover

2020

Geriatrics

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A growing body of literature is focused on the use of eye tracking (ET) technology to understand the association between objective visual parameters and higher order brain processes such as cognition. One of the settings where this principle has found practical utility is in the area of driving safety. Methods: We reviewed the literature to identify the changes in ET parameters with older adults and neurodegenerative disease. Results: This narrative review provides a brief overview of oculomotor system anatomy and physiology, defines common eye movements and tracking variables that are typically studied, explains the most common methods of eye tracking measurements during driving in simulation and in naturalistic settings, and examines the association of impairment in ET parameters with advanced age and neurodegenerative disease. Conclusion: ET technology is becoming less expensive, more portable, easier to use, and readily applicable in a variety of clinical settings. Older adults and especially those with neurodegenerative disease may have impairments in visual search parameters, placing them at risk for motor vehicle crashes. Advanced driver assessment systems are becoming more ubiquitous in newer cars and may significantly reduce crashes related to impaired visual search, distraction, and/or fatigue.

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“…Eye tracking is non-invasive and little training is needed to collect eye tracking data. Prior work has shown that eye movements can be used to indicate clinically-relevant neuromotor and cognitive deficits (25)(26)(27), including those measured by ImPACT. As there is a physical link between the optic nerve and the eye (i.e., its physical connection), it stands to reason that there is also a link between increased ONSD (i.e., swelling of the optic nerve) and eye movements.…”

Section: Introductionmentioning

confidence: 99%

Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes

et al. 2021

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There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilitation. The focus of the present study is to investigate the potential for oculomotor features to complement existing diagnostic tools, such as measurements of Optic Nerve Sheath Diameter (ONSD) and Immediate Post-concussion Assessment and Cognitive Testing (ImPACT). Thirty-one high school American football and soccer athletes were tracked through the course of a sports season. Given the high risk of repetitive head impacts associated with both soccer and football, our hypotheses were that (1) ONSD and ImPACT scores would worsen through the season and (2) oculomotor features would effectively capture both neurophysiological changes reflected by ONSD and neuro-functional status assessed via ImPACT. Oculomotor features were used as input to Linear Mixed-Effects Regression models to predict ONSD and ImPACT scores as outcomes. Prediction accuracy was evaluated to identify explicit relationships between eye movements, ONSD, and ImPACT scores. Significant Pearson correlations were observed between predicted and actual outcomes for ONSD (Raw = 0.70; Normalized = 0.45) and for ImPACT (Raw = 0.86; Normalized = 0.71), demonstrating the capability of oculomotor features to capture neurological changes detected by both ONSD and ImPACT. The most predictive features were found to relate to motor control and visual-motor processing. In future work, oculomotor models, linking neural structures to oculomotor function, can be built to gain extended mechanistic insights into neurophysiological changes observed through seasons of participation in contact sports.

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Eye tracking – The overlooked method to measure cognition in neurodegeneration?

Cited by 49 publications

References 136 publications

Evidence of inverted gravity‐driven variation in predictive sensorimotor function

Evidence of inverted gravity‐driven variation in predictive sensorimotor function

The Role of Eye Tracking Technology in Assessing Older Driver Safety

Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes

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