Eye-Specific IOP-Induced Displacements and Deformations of Human Lamina Cribrosa

Sigal, Ian A.; Grimm, J.; Jan, Ning-Jiun; Reid, Korey M.; Minckler, Don S.; Brown, Donald J.

doi:10.1167/iovs.13-12724

Cited by 125 publications

(129 citation statements)

References 72 publications

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“…This limitation, however, is shared by most methods used to characterize ocular collagen. Often, methods that can, in theory, provide three-dimensional information, such as nonlinear imaging, are still used in two-dimensions due to the complexities of the tissue [10,51]. Also, the orientation data obtained from our PLM at each pixel represents the predominant fiber orientation at that point.…”

Section: Discussionmentioning

confidence: 99%

Polarization microscopy for characterizing fiber orientation of ocular tissues

Jan

Grimm

Tran

et al. 2015

Biomed. Opt. Express

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150

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Characterizing the collagen fiber orientation and organization in the eye is necessary for a complete understanding of ocular biomechanics. In this study, we assess the performance of polarized light microscopy to determine collagen fiber orientation of ocular tissues. Our results demonstrate that the method provides objective, accurate, repeatable and robust data on fiber orientation with µm-scale resolution over a broad, cmscale, field of view, unaffected by formalin fixation, without requiring tissue dehydration, labeling or staining. Together, this shows that polarized light microscopy is a powerful method for studying collagen architecture in the eye, with applications ranging from normal physiology and aging, to pathology and transplantation.

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Section: Discussionmentioning

confidence: 99%

Polarization microscopy for characterizing fiber orientation of ocular tissues

Jan

Grimm

Tran

et al. 2015

Biomed. Opt. Express

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150

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“…37 The increases in signal intensities and MR transverse relaxation times might be due to the realignment of the collagen fibers, such as decrease in waviness of fiber crimps (Sigal et al IOVS 2013;54:ARVO EAbstract 3158) 56 and reorientation of scleral and corneal lamellar fibers 3,49-51 upon stretch and compression. 5,[57][58][59] Down to the atomic level, it could also reflect the fiber protons being moved further apart, resulting in diminishing spin FIGURE 5. (a) Qualitative and (b) quantitative assessments of the magic angle effect on relative T2*-weighted signal intensities (mean 6 standard deviation) in normal unloaded tendon, anterior sclera, and cornea (white arrows).…”

Section: Discussionmentioning

confidence: 99%

Magic Angle–Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading

Sigal

Jan

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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“…[193] Tissue sectioning for histology, while powerful, is subject to limitations and potential confounders (discussed in [194]). Hence, methods have also been developed to study LC biomechanics and architecture ex-vivo without the need to section the tissue, for example using second harmonic generated images[195]. These have enabled measurement of eye-specific displacements and deformations of the human LC induced by acute increases in IOP.…”

Section: Lamina Cribrosa Biomechanicsmentioning

confidence: 99%

Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects

Girard

Dupps

Baskaran

et al. 2014

Current Eye Research

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Biomechanics – the study of the relationship between forces and function in living organisms – is thought to play a critical role in a significant number of ophthalmic disorders. This is not surprising, as the eye is a pressure vessel that requires a delicate balance of forces to maintain its homeostasis. Over the past few decades, basic science research in ophthalmology mostly confirmed that ocular biomechanics could explain in part the mechanisms involved in almost all major ophthalmic disorders such as optic nerve head neuropathies, angle closure, ametropia, presbyopia, cataract, corneal pathologies, retinal detachment, and macular degeneration. Translational biomechanics in ophthalmology, however, is still in its infancy. It is believed that its use could make significant advances in diagnosis and treatment. Several translational biomechanics strategies are already emerging, such as corneal stiffening for the treatment of keratoconus, and more are likely to follow. This review aims to cultivate the idea that biomechanics plays a major role in ophthalmology and that its clinical translation, lead by collaborative teams of clinicians and biomedical engineers, will benefit our patients. Specifically, recent advances and future prospects in corneal, iris, trabecular meshwork, crystalline lens, scleral and lamina cribrosa biomechanics are discussed.

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Eye-Specific IOP-Induced Displacements and Deformations of Human Lamina Cribrosa

Cited by 125 publications

References 72 publications

Polarization microscopy for characterizing fiber orientation of ocular tissues

Polarization microscopy for characterizing fiber orientation of ocular tissues

Magic Angle–Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading

Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects

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