Eye regeneration in the mystery snail

Bever, Michele Miller; Borgens, Richard B.

doi:10.1002/jez.1402450106

Cited by 17 publications

(11 citation statements)

References 15 publications

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“…Pomacea canaliculata ( Pc ) is a freshwater snail attracting interest from many points of view, including an outstanding resistance to stressing conditions and a remarkable regeneration capability in adults . Pc fecundity and adaptability to reproduce in wide ranging environments lead to be indexed among the 100 most invasive species by the Invasive Species Specialist Group .…”

Section: Proteins Identified From Circulating Hemocytes Of Pc By Lc‐mmentioning

confidence: 99%

Toward the Molecular Deciphering of Pomacea canaliculata Immunity: First Proteomic Analysis of Circulating Hemocytes

et al. 2019

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Pomacea canaliculata is a freshwater snail with interesting biological features that include invasiveness, human parasite hosting, and adult regeneration. Its immune system may represent the target for strategies aimed at controlling the spread of the snail population and its hosting of the human parasite Angiostrongylus cantonensis. Moreover, immune functions likely have a role in the snail's ability to wound heal and regenerate. Despite its importance in multiple processes, very little is known about the molecular basis of P. canaliculata immunity. Aiming to contribute to filling this gap, the ultrastructure of circulating hemocytes in healthy snails is studied and the first proteomic analysis of these cells is performed, evidencing 83 unique proteins, 96% of which have identifiable homologs in other species. Fifteen proteins are retrieved as potentially involved in immune‐related signaling pathways, such as hemocyanin, C1q‐like protein, and HSP90 together with cytoskeleton and cytoskeleton‐related proteins involved in cell motility and membrane dynamics. This first proteome study on non‐stimulated hemocytes provides a valid reference for future investigations on the molecular changes under stressful circumstances, like pathogen exposure, wounding, or environmental changes.

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Section: Proteins Identified From Circulating Hemocytes Of Pc By Lc‐mmentioning

confidence: 99%

Toward the Molecular Deciphering of Pomacea canaliculata Immunity: First Proteomic Analysis of Circulating Hemocytes

et al. 2019

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“…Moreover pulmonate eyes generally require a much longer regeneration time than do those of, for example, I. obsoleta (Gibson 1984), other neogastropods (Hughes 1976), or the mystery snail Pomacea sp. (Bever and Borgens 1988).…”

Section: Discussionmentioning

confidence: 99%

“…(Hughes 1976; Gillary 1983), Ilyanassa obsoleta (Gibson 1984), Pomacea sp. (Bever and Borgens 1988) and Hydrobia ulvae (Gorbushin et al . 2001).…”

Section: Introductionmentioning

confidence: 99%

Restoration of morphological and functional integrity in the regenerating eye of the giant African land snail Achatina fulica

et al. 2004

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 Abstract Bobkova, M.V., Tartakovskaya, O.S., Borissenko, S.L., Zhukov, V.V. & Meyer-Rochow, V.B. 2004. Restoration of morphological and functional integrity in the regenerating eye of the giant African land snail Achatina fulica . -Acta Zoologica (Stockholm) 85 : 1-14To determine whether vision returns to its original state following eye removal in Achatina fulica , light and electron microscope examinations, electrophysiological recordings and behavioural tests were carried out on the regenerating snails. Reparative morphogenesis can result in the restoration of the peripheral sense organ even in the absence of complete regrowth of the tentacle, but it can also lead to the formation of aberrant regenerates. We found that anatomically and ultrastructurally the eyes of the 'most normal' regenerates were basically the same as the original eyes. Under normal conditions each eye is composed of a principal and an accessory eye, both sharing a common cornea. The only difference between regenerated and native eyes is the smaller size of the former, as a result of a reduced number of retinal cells. Electroretinographic responses revealed that the molecular mechanism of phototransduction is restored, in principle, but that flicker fusion frequency in the regenerated eye is significantly lower than in the normal eye. The directional movement to a visual stimulus (a black stripe of 45 ° width) had not completely recovered even 6 months after amputation. This suggests that the central projections of the optic nerve had not become fully re-established at the time of testing.

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“…Regenerations of this kind occur widely in caenogastropod (Gibson 1984; Bever & Borgens 1988a,b; Gorbushin et al 2001) and pulmonate species (Eakin & Ferlatte 1973; Scarsso & Pellegrino de Iraldi 1973; Price 1977; Flores & Pellegrino de Iraldi 1980; Flores et al 1983; Sidelnikov 1991; Zakharov et al 1998). For instance, caenogastropod species of the families Ampullariidae (mystery snails), Strombidae (true conchs), and Nassariidae (mud snails) can re‐grow an eye with corresponding optic nerve structures within several weeks (Hughes 1976; Gibson 1984; Bever & Borgens 1988a,b). In studies with the marine snail Ilyanassa obsoleta (S ay , 1822), behavioral tests were used to determine the time when vision in individuals with regenerating eyes returned (Gibson 1984).…”

Section: Visual System Regeneration In Gastropodsmentioning

confidence: 99%

Regeneration of the visual system in gastropods (Mollusca)

Tuchina

Meyer-Rochow

2010

Invertebrate Biology

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Abstract. The topic of tissue and organ regeneration has been of interest to life scientists ever since the phenomenon was noticed. The reason for this is obvious: if one can learn what drives and controls regeneration, i.e., how lost or damaged structures can be replaced, one not only has a better chance to understand an animal's embryogenesis and evolutionary relationship with other taxa, but one would also be in a better position to treat organ loss or tissue damage in humans. In this context, the possible restitution of individual sensory neurons or nerve projections has been of special interest to us. We identified central visual projections in several gastropod species and found that: (1) projections are very extensive across the brain and (2) they have connections with other systems and organs (including, most likely, non‐ocular skin photoreceptors) that may be involved in the integration of signals from different sensors. Investigations of afferent and efferent visual elements at a morphological level should help reveal the neuronal basis of a gastropod's behavioral reactions.

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Eye regeneration in the mystery snail

Cited by 17 publications

References 15 publications

Toward the Molecular Deciphering of Pomacea canaliculata Immunity: First Proteomic Analysis of Circulating Hemocytes

Toward the Molecular Deciphering of Pomacea canaliculata Immunity: First Proteomic Analysis of Circulating Hemocytes

Restoration of morphological and functional integrity in the regenerating eye of the giant African land snail Achatina fulica

Regeneration of the visual system in gastropods (Mollusca)

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