Eye Position Influences Auditory Responses in Primate Inferior Colliculus

Groh, Jennifer M.; Trause, Amanda S.; Underhill, Abigail M.; Clark, Kristi; Inati, Souheil

doi:10.1016/s0896-6273(01)00222-7

Cited by 189 publications

(197 citation statements)

References 51 publications

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“…Transient eccentric eye position (Ͻ5 s) has also been shown to modulate the spatial responses of auditory neurons in the inferior colliculus (Groh et al, 2001;Zwiers et al, 2004), superior colliculus (Jay and Sparks, 1987;Hartline et al, 1995;Peck et al, 1995;Zella et al, 2001;Populin et al, 2004), auditory cortex (WernerReiss et al, 2003;Fu et al, 2004), and the intraparietal sulcus (Stricanne et al, 1996;Mullette-Gillman et al, 2005). These short-term effects may reflect a step in the eye-to-head-centered transformation of sound source coordinates, their associated errors, or an early component of the auditory spatial adaptation reported here.…”

Section: Discussionsupporting

confidence: 50%

Auditory Spatial Perception Dynamically Realigns with Changing Eye Position

Razavi¹,

O’Neill²,

Paige³

2007

J. Neurosci.

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Audition and vision both form spatial maps of the environment in the brain, and their congruency requires alignment and calibration. Because audition is referenced to the head and vision is referenced to movable eyes, the brain must accurately account for eye position to maintain alignment between the two modalities as well as perceptual space constancy. Changes in eye position are known to variably, but inconsistently, shift sound localization, suggesting subtle shortcomings in the accuracy or use of eye position signals. We systematically and directly quantified sound localization across a broad spatial range and over time after changes in eye position. A sustained fixation task addressed the spatial (steady-state) attributes of eye position-dependent effects on sound localization. Subjects continuously fixated visual reference spots straight ahead (center), to the left (20°), or to the right (20°) of the midline in separate sessions while localizing auditory targets using a laser pointer guided by peripheral vision. An alternating fixation task focused on the temporal (dynamic) aspects of auditory spatial shifts after changes in eye position. Localization proceeded as in sustained fixation, except that eye position alternated between the three fixation references over multiple epochs, each lasting minutes. Auditory space shifted by ϳ40% toward the new eye position and dynamically over several minutes. We propose that this spatial shift reflects an adaptation mechanism for aligning the "straight-ahead" of perceived sensory-motor maps, particularly during early childhood when normal ocular alignment is achieved, but also resolving challenges to normal spatial perception throughout life.

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Section: Discussionsupporting

confidence: 50%

Auditory Spatial Perception Dynamically Realigns with Changing Eye Position

Razavi¹,

O’Neill²,

Paige³

2007

J. Neurosci.

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“…The eyes were in different positions during these two time periods, so in principle, this test could have picked up neurons based on their eye-position sensitivity (Groh et al, 2001;Zwiers et al, 2004). However, this test was conducted on pooled data involving both leftward and rightward saccades to sounds, which would have tended to minimize the contribution of eye-position sensitivity to the population of neurons selected by this means.…”

Section: Resultsmentioning

confidence: 99%

Effects of Reward and Behavioral Context on Neural Activity in the Primate Inferior Colliculus

2006

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Neural activity in the inferior colliculus (IC) likely plays an integral role in the processing of various auditory parameters, such as sound location and frequency. However, little is known about the extent to which IC neural activity may be influenced by the context in which sounds are presented. In this study, we examined neural activity of IC neurons in the rhesus monkey during an auditory task in which a sound served as a localization target for a saccade. Correct performance was rewarded, and the magnitude of the reward was varied in some experiments. Neural activity was also assessed during a task in which the monkey maintained fixation of a light while ignoring the sound, as well as when sounds were presented in the absence of any task. We report that neural activity increased late in the trial in the saccade task in 58% of neurons and that the level of activity throughout the trials could be modulated by reward magnitude for many neurons. The late-trial neural activity similarly increased in the fixation task in 39% of the neurons tested for this task but was not observed when sounds were presented in the absence of a behavioral task and reward. Together, these results suggest that a rewardrelated signal influences neural activity in the IC.

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“…This indicates that, in monkeys, vision and audition are combined into a common neural representation using eye-centered coordinates for reaching. The transformation of the position of auditory targets from head-centered to retinotopic coordinates appears to start early since auditory cells with head-centered receptive fields are modulated by the position of the gaze in the inferior colliculus (Groh, Trause, Underhill, Clark, & Inati, 2001) and in the primary auditory cortex (Trause, Werner-Reiss, Underhill, & Groh, 2000). These observations are consistent with our findings although more work is required before a causal relationship can be established.…”

Section: Discussionmentioning

confidence: 99%

Multisensory spatial representations in eye-centered coordinates for reaching

et al. 2002

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Humans can reach for objects with their hands whether the objects are seen, heard or touched. Thus, the position of objects is recoded in a joint-centered frame of reference regardless of the sensory modality involved. Our study indicates that this frame of reference is not the only one shared across sensory modalities. The location of reaching targets is also encoded in eye-centered coordinates, whether the targets are visual, auditory, proprioceptive or imaginary. Furthermore, the remembered eye-centered location is updated after each eye and head movement. This is quite surprising since, in principle, a reaching motor command can be computed from any non-visual modality without ever recovering the eye-centered location of the stimulus. This finding may reflect the predominant role of vision in human spatial perception. q

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Eye Position Influences Auditory Responses in Primate Inferior Colliculus

Cited by 189 publications

References 51 publications

Auditory Spatial Perception Dynamically Realigns with Changing Eye Position

Auditory Spatial Perception Dynamically Realigns with Changing Eye Position

Effects of Reward and Behavioral Context on Neural Activity in the Primate Inferior Colliculus

Multisensory spatial representations in eye-centered coordinates for reaching

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