Eye disorders in patients with celiac disease and inflammatory bowel disease: A study using clinical data warehouse

Martins, Thiago Gonçalves dos Santos; Sipahi, Aytan Miranda; Santos, Fabiana Maria dos; Schor, Paulo; Anschütz, Andreas; Mendes, Luís; Silva, Rufino

doi:10.1177/11206721211012849

Cited by 5 publications

(4 citation statements)

References 40 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ocular manifestations of celiac disease are not different from the ocular manifestations of other inflammatory bowel diseases. [18] Table 1…”

Section: Inflammation Of the Orbital Musclesmentioning

confidence: 99%

Manifestations of Ocular Autoimmune Diseases - Literature Review

Borowska-Waniak,

Michalik,

Marcinkiewicz

et al. 2023

ArveMED

View full text Add to dashboard Cite

Ocular manifestations in autoimmune diseases are mainly related to the formation of a chronic inflammatory process in the body. This is caused by an error in the body's histocompatibility system, which results in the lymphocyte attacking its own cells, which the lymphocyte considers foreign. Various autoimmune diseases with ocular symptoms may have different inflammation-related pathophysiology, ranging from increased vascular permeability in diabetic retinopathy to lymphocytic pressure in the exocrine glands in Sjögren's syndrome. The inflammatory process in the eye tissues leads to symptoms such as pain, redness, photosensitivity, tearing and reduced visual acuity. One of the most common autoimmune diseases associated with ocular symptoms is systemic lupus erythematosus, in which 50% of patients experience ocular symptoms. Ocular manifestations may worsen or improve depending on disease activity. Ophthalmological examination is extremely important for patients with autoimmune diseases because it allows for the early detection and treatment of eye-related diseases, monitoring the side effects of medications taken, and identifying other related health problems.

show abstract

“…The ocular manifestations of celiac disease are not different from the ocular manifestations of other inflammatory bowel diseases. [18] Table 1…”

Section: Inflammation Of the Orbital Musclesmentioning

confidence: 99%

Manifestations of Ocular Autoimmune Diseases - Literature Review

Borowska-Waniak,

Michalik,

Marcinkiewicz

et al. 2023

ArveMED

View full text Add to dashboard Cite

show abstract

“…8 Martins et al recently described a DED prevalence of 32%, 19%, and 12% in patients with celiac disease, Crohn's disease (CD), and ulcerative colitis (UC), respectively. 9…”

Section: Epidemiologic Features Of Dry Eye Disease (Ded) In Autoimmun...mentioning

confidence: 99%

“…8 Martins et al recently described a DED prevalence of 32%, 19%, and 12% in patients with celiac disease, Crohn's disease (CD), and ulcerative colitis (UC), respectively. 9 The Dry Eye Assessment and Management (DREAM) Study (clinicaltrials.gov identifier, NCT02128763) evaluated if systemic conditions known to be risk factors for DED are also associated with the severity of DED signs and symptoms. 10 Of 535 patients included, 81.1% were females, 17.6% had thyroid dysfunction, 10.7% had DM-I or II, 8.8% had RA, and 5.0% had Sjögren syndrome (SS).…”

Section: Epidemiologic Features Of Dry Eye Disease (Ded) In Autoimmun...mentioning

confidence: 99%

Dry eye disease, a prominent manifestation of systemic autoimmune disorders

Bustamante-Arias

Ruiz-Lozano

Rodríguez-García

2022

European Journal of Ophthalmology

View full text Add to dashboard Cite

Objectives Dry eye disease (DED) is arguably the most frequent ocular disease encountered in ophthalmic clinical practice. DED is frequently an underestimated condition causing a significant impact on visual function and quality of life. Many systemic autoimmune diseases (SAIDs) are related to moderate to severe DED. The main objective of this review is to enhance the awareness among ophthalmologists of the potential association of an underlying SAID in a high-risk patient with DED. Methods An exhaustive literature search was performed in the National Library of Medicine's Pubmed, Scopus, Web of Science, and Google Scholar databases for all English language articles published until November 2021. The main keywords included “dry eye disease” associated with autoimmune, connective tissue, endocrine, gastrointestinal, hematopoietic, vascular, and pulmonary diseases. Case reports, series, letters to the editor, reviews, and original articles were included. Results Although DED is frequently associated with SAIDs, its diagnosis is commonly delayed or missed, producing significant complications, including corneal ulceration, melting, scleritis, uveitis, and optic neuritis resulting in severe complications detrimental to visual function and quality of life. SAID should be suspected in a woman, 30 to 60 years old with a family history of autoimmunity, presenting with DED symptoms and extraocular manifestations including arthralgias, dry mouth, unexplained weight and hair loss, chronic fatigue, heat or cold intolerance, insomnia, and mood disorders. Conclusions Establishing the correct diagnosis and treatment of DED associated with SAIDs is crucial to avoid its significant burden and severe ocular complications.

show abstract

“…These are factors that can also affect cataracts 11 , 12 , so it can be hypothesized that cataracts and fatty liver are closely related. The two diseases may be connected through various mechanisms; for example, patients with inflammatory bowel disease have a high prevalence of both fatty liver and cataract 13 , 14 .…”

Section: Introductionmentioning

confidence: 99%

Association between cataract and fatty liver diseases from a nationwide cross-sectional study in South Korea

Kang,

Shin,

Ryu

et al. 2024

Sci Rep

View full text Add to dashboard Cite

This study examined the link between fatty liver disease (FLD) and cataracts, as previous research has suggested that FLD may contribute to metabolic syndrome, systemic inflammation, and potentially cataracts. We studied a nationwide cross-sectional cohort of the Fifth Korean National Health and Nutrition Examination Survey 2010–2011. FLD was defined as nonalcoholic FLD (NAFLD) and metabolic dysfunction-associated FLD (MAFLD). Multinomial logistic regression was utilized to investigate the relationship between cataracts and FLD after adjustment for potential confounders. Participants with cataracts had higher liver fibrosis scores, including the NAFLD fibrosis score (NFS; P < 0.001), fibrosis-4 index (FIB4; P < 0.001), and fatty liver index (FLI; P = 0.001). NAFLD was not associated with a higher odds ratio (OR) for cataracts in the fully adjusted model (OR = 1.23, P = 0.058). MAFLD was significantly associated with a higher OR (OR = 1.34, P = 0.006). After adjusting for all factors, the severity of FLD was linked to an increased risk of cataracts, with significant linear trends (P values for linear trends of NFS, FIB4, and FLI < 0.05). After adjusting for well-known cataract risk factors, MAFLD was significantly associated with cataracts. Our analysis suggests that FLD may serve as an independent risk factor for cataracts.

show abstract

Eye disorders in patients with celiac disease and inflammatory bowel disease: A study using clinical data warehouse

Cited by 5 publications

References 40 publications

Manifestations of Ocular Autoimmune Diseases - Literature Review

Manifestations of Ocular Autoimmune Diseases - Literature Review

Dry eye disease, a prominent manifestation of systemic autoimmune disorders

Association between cataract and fatty liver diseases from a nationwide cross-sectional study in South Korea

Contact Info

Product

Resources

About