Eye Changes in Ichthyosis

Eye changes in a patient with lamellar ichthyosis and toe pseudoainhum

“…[6][7][8] Ectropion of the lower eyelid was assumed to cause exposure keratopathy in severe cases. 7 Conversely, Cruz et al 8 postulated that corneal damage is not directly linked to lower ectropion.…”

“…[6][7][8] Ectropion of the lower eyelid was assumed to cause exposure keratopathy in severe cases. 7 Conversely, Cruz et al 8 postulated that corneal damage is not directly linked to lower ectropion. These authors suggested that the interaction between eyelid malposition and corneal disease is complex and corneal damage depends on several factors, including lower ectropion, upper eyelid restriction, lack of Bell's phenomenon, and eyelash retraction.…”

Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis.

“…It was separated from autosomal dominant ichthyosis vulgaris in 1965 on the basis ofpedigree analysis and clinical features (1). The latter include earlier age of onset, sparing of the palms and soles, Received for publication 8 September 1980 and in revised form 10 December 1980. pearance especially on the side of the neck, and the subsequently described comeal stippling (2). Although these findings permit clinical differentiation of groups of patients, it is often difficult to assign a diagnosis to an individual male patient.…”

X-Linked Recessive Ichthyosis

“…Deep corneal opacities were found in XRI patients by Sever et al [26], and later by other investigators [20].…”