Eye

Ludwig, Annick; Reimann, Holger

doi:10.1007/978-3-319-15814-3_10

Cited by 5 publications

(1 citation statement)

References 101 publications

(106 reference statements)

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“…Generally, higher surface tension values correspond to lower tear film stability, as it is the case in dry eye disease, where a surface tension range of 44-53 mN m -1 has been reported (29,30). The surface tension of an ophthalmic formulation should be close to 35 mN m -1 , since there are indications that the administration of formulations with lower surface tension may be painful and uncomfortable (30,31).…”

Section: Preparation and Physicochemical Characterization Of Cationicmentioning

confidence: 99%

In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery

et al. 2019

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Oil-in-water nanoemulsions (NEs) represent one of the formulation approaches to improve eye-related bio-availability of lipophilic drugs. The potential of cationic NEs is pronounced due to the electrostatic interaction of positively charged droplets with negatively charged mucins present in the tear film, providing prolonged formulation residence at the ocular surface. The aim of this study was to develop a cationic ophthalmic NE with cationic lipid stearylamine (SA) as a carrier of a positive charge. The addition of a nonionic surfactant provided the dual electro-steric stabilization of NEs and enabled tuning of SA concentration to achieve an optimal balance between its interaction with mucins and biocompatibility. Physicochemical characterization, stability profile, in vitro mucoadhesion study and biocompatibility study employing 3D HCE-T cell-based model of corneal epithelium pointed out the NE with 0.05 % (m/m) SA as the leading formulation. Minimizing SA content while retaining droplet/mucin interactions is of great importance for efficacy and safety of future ophthalmic drug products.

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Section: Preparation and Physicochemical Characterization Of Cationicmentioning

confidence: 99%

In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery

et al. 2019

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Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves

Kojima

Suzuki

Sasaki

et al. 2018

J Infrared Milli Terahz Waves

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The objective of this study was to develop a model of ocular damage induced by 40, 75, and 95 GHz continuous millimeter waves (MMW), thereby allowing assessment of the clinical course of ocular damage resulting from exposure to thermal damage-inducing MMW. This study also examined the dependence of ocular damage on incident power density. Pigmented rabbit eyes were exposed to 40, 75, and 95 GHz MMW from a spot-focus-type lens antenna. Slight ocular damage was observed 10 min after MMW exposure, including reduced cornea thickness and reduced transparency. Diffuse fluorescein staining around the pupillary area indicated corneal epithelial injury. Slit-lamp examination 1 day after MMW exposure revealed a round area of opacity, accompanied by fluorescence staining, in the central pupillary zone. Corneal edema, indicative of corneal stromal damage, peaked 1 day after MMW exposure, with thickness gradually subsiding to normal. Three days after exposure, ocular conditions had almost normalized, though corneal thickness was slightly greater than that before exposure. The 50% probability of ocular damage (DD 50 ) was in the order 40 > 95 ≈ 75 GHz at the same incident power densities. J Infrared Milli Terahz Waves (2018) 39:912-925 https://doi

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