Exudative Neutrophils

Abstract

The microbicidal activity of neutrophils is enhanced after exudation and is associated with neutrophil priming. The inability of exogenous tumor necrosis factor to further augment superoxide production after exudation suggests that this priming has been maximized.

Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha.

“…Marginated leukocytes rapidly migrate to the extravascular space where exposure to additional stimuli causes release of reactive oxygen species and proteolytic enzymes (2,3). One consequence of the destructive environment surrounding activated PMN is the shedding of surface proteins such as L-selectin (4) and TNF receptors (5).…”