Extrinsic intestinal denervation modulates tumor development in the small intestine of ApcMin/+ mice

Liu, Verena; Dietrich, Alexandra; Kasparek, Michael S.; Benhaqi, Petra; Schneider, Marlon R.; Schemann, Michael; Seeliger, Hendrik; Kreis, Martin E.

doi:10.1186/s13046-015-0159-0

Cited by 20 publications

(16 citation statements)

References 36 publications

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“…Moreover, the amount of neurogenesis inversely correlates with the survival of colorectal cancer patient . Consistently in APC Min/+ mice, it has been demonstrated that vagal nerve innervation promotes tumour growth in the small intestine . Vagal neurons drive the production of protein trefoil factor 2 by splenic memory T cells helping to suppress myeloid‐derived suppressor cell (MDSC) activity.…”

Section: Endogenous Triggersmentioning

confidence: 94%

“…They do so by driving ILC2 cells , CD4 , or dermal dendritic cells activity. However, somatosensory neurons appear to block T H 1 or T H 17 immunity as observed in the context of bacterial and fungal infection as well as anti‐tumour immunity . Neurons initiate such effects by secreting CGRP, which blocks the activity of neutrophils and CD301b + dermal dendritic cells .…”

Section: Clinical Relevancementioning

confidence: 99%

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Profiling of how nociceptor neurons detect danger – new and old foes

et al. 2019

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The host evolves redundant mechanisms to preserve physiological processing and homeostasis. These functions range from sensing internal and external threats, creating a memory of the insult and generating reflexes, which aim to resolve inflammation. Impairment in such functioning leads to chronic inflammatory diseases. By interacting through a common language of ligands and receptors, the immune and sensory nervous systems work in concert to accomplish such protective functions. Whilst this bidirectional communication helps to protect from danger, it can contribute to disease pathophysiology. Thus, the somatosensory nervous system is anatomically positioned within primary and secondary lymphoid tissues and mucosa to modulate immunity directly. Upstream of this interplay, neurons detect danger, which prompts the release of neuropeptides initiating (i) defensive reflexes (ranging from withdrawal response to coughing) and (ii) chemotaxis, adhesion and local infiltration of immune cells. The resulting outcome of such neuro‐immune interplay is still ill‐defined, but consensual findings start to emerge and support neuropeptides not only as blockers of TH1‐mediated immunity but also as drivers of TH2 immune responses. However, the modalities detected by nociceptors revealed broader than mechanical pressure and temperature sensing and include signals as various as cytokines and pathogens to immunoglobulins and even microRNAs. Along these lines, we aggregated various dorsal root ganglion sensory neuron expression profiling datasets supporting such wide‐ranging sensing capabilities to help identifying new danger detection modalities of these cells. Thus, revealing unexpected aspects of nociceptor neuron biology might prompt the identification of novel drivers of immunity, means to resolve inflammation and strategies to safeguard homeostasis.

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Section: Endogenous Triggersmentioning

confidence: 94%

Section: Clinical Relevancementioning

confidence: 99%

Profiling of how nociceptor neurons detect danger – new and old foes

et al. 2019

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“…Like angiogenesis and lymphogenesis in cancer, the term "neo-neurogenesis" has been coined by cancer researchers to study functional roles played by the neural system in cancer 4,5 . Functional involvement of neural processes in cancer has been studied by numerous authors, such as that (1) perineural invasion has been observed in multiple cancer types 6,7 ; (2) cancer cells surrounding nerves tend to be more resistant to apoptosis 8,9 ; and (3) denervation has been found to be effective in slowing down cancer progression [10][11][12] . Furthermore, cross-talks have been observed between cancer cells and nerves, including neurites growing towards cancer cells and cancer cells invading nerves 13,14 .…”

mentioning

confidence: 99%

Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC

Tan

Huang

et al. 2020

Sci Rep

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Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, and yet our understanding about its unique biology remains elusive. We have conducted a comparative computational analysis of transcriptomic data of TNBC and non-TNBC (NTNBC) tissue samples from the TCGA database, focused on genes involved in neural functions. Our main discoveries are: (1) while both subtypes involve neural functions, TNBC has substantially more up-regulated neural genes than NTNBC, suggesting that TNBC is more complex than NTNBC; (2) non-neural functions related to cellmicroenvironment interactions and intracellular damage processing are key inducers of the neural genes in both TNBC and NTNBC, but the inducer-responder relationships are different in the two cancer subtypes; (3) key neural functions such as neural crest formation are predicted to enhance adaptive immunity in TNBC while glia development, along with a few other neural functions, induce both innate and adaptive immunity in NTNBC. These results reveal key differences in the biology between the two cancer subtypes, particularly in terms of the roles that neural functions play. Our findings may open new doors for further investigation of the distinct biology of TNBC vs. NTNBC.

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“…The role of the gut-brain axis, which includes the ENS, in carcinogenesis is underestimated and vastly understudied. For example, colon tumor development in the Apc(Min/+) mouse model is inhibited after vagotomy, but not by sympathetic denervation (Liu et al, 2015). Last but not least, the ENS is the target of paraneoplastic neurological autoimmunity often associated with small cell lung cancer.…”

Section: Transmittermentioning

confidence: 99%

The enteric nervous system: “A little brain in the gut”

Annaházi

Schemann²

2020

Neuroforum

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AbstractThe gut’s own autonomous nervous system, the enteric nervous system (ENS), has fascinated scientists for more than 100 years. It functions, in the true sense of the word, autonomously, by performing complex tasks and controlling vital functions independently of extrinsic inputs. At the same time, the ENS is bombarded with signals from other cells in the gut wall and lumen and has to integrate all of these inputs. We describe the main functions of the ENS under physiological conditions and give a few examples of its role in gut diseases. The ENS has received increasing attention recently as scientists outside the field of Neurogastroenterology realize its important role in the pathogenesis of Parkinson’s, autism and multiple sclerosis.

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Extrinsic intestinal denervation modulates tumor development in the small intestine of ApcMin/+ mice

Cited by 20 publications

References 36 publications

Profiling of how nociceptor neurons detect danger – new and old foes

Profiling of how nociceptor neurons detect danger – new and old foes

Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC

The enteric nervous system: “A little brain in the gut”

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