Extrinsic and Intrinsic Apoptosis Signal Pathway Review

Hongmei, Zhao

doi:10.5772/50129

Cited by 106 publications

(105 citation statements)

References 59 publications

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“…The type of cell death selected depends on the stimulus and the cellular context and is a result of self-propagating signals [24]. Two distinct pathways initiate apoptosis: caspase-dependent or caspaseindependent pathway [25]. In the active form, several caspase proteins lead to cell apoptosis.…”

Section: Introductionmentioning

confidence: 99%

D-Galactose Causes Motor Coordination Impairment, and Histological and Biochemical Changes in the Cerebellum of Rats

et al. 2016

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Classical galactosemia is an inborn error of carbohydrate metabolism in which patients accumulate high concentration of galactose in the brain. The most common treatment is a galactose-restricted diet. However, even treated patients develop several complications. One of the most common symptoms is motor coordination impairment, including affected gait, balance, and speech, as well as tremor and ataxia. In the present study, we investigated the effects of intracerebroventricular galactose administration on motor coordination, as well as on histological and biochemical parameters in cerebellum of adult rats. Wistar rats received 5 μL of galactose (4 mM) or saline by intracerebroventricular injection. The animals performed the beam walking test at 1 and 24 h after galactose administration. Histological and biochemical parameters were performed 24 h after the injections. The results showed motor coordination impairment at 24 h after galactose injection. Galactose also decreased the number of cells in the molecular and granular layers of the cerebellum. The immunohistochemistry results suggest that the cell types lost by galactose are neurons and astrocytes in the spinocerebellum and neurons in the cerebrocerebellum. Galactose increased active caspase-3 immunocontent and acetylcholinesterase activity, decreased acetylcholinesterase immunocontent, glutathione, and BDNF levels, as well as caused protein and DNA damage. Our results suggest that galactose induces histological and biochemical changes in cerebellum, which can be associated with motor coordination impairment.

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Section: Introductionmentioning

confidence: 99%

D-Galactose Causes Motor Coordination Impairment, and Histological and Biochemical Changes in the Cerebellum of Rats

et al. 2016

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“…These pathways are known as caspase-dependent and caspase-independent pathways. Caspase-3 and caspase-9 usually participate in caspase dependent apoptotic pathway and apoptosis inducing factor (AIF) is the major important pro-apoptosis factor for caspase independent apoptotic pathway (13).…”

Section: Discussionmentioning

confidence: 99%

GSM-like radiofrequency exposure induces apoptosis via caspase-dependent pathway in infant rabbits

Meral¹,

Ozgur²,

Kısmalı³

et al. 2017

BLL

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BACKGROUND: There have been several Radio Frequency (RF) fi eld researches on various populations and groups of different ages in recent years. However, the most important group for research has been declared as the pregnant women and their babies. OBJECTIVE: The aim of the study was to analyse the effect on apoptotic factors of RF fi elds on newborn rabbit liver tissues. MATERIALS AND METHODS: Cytochrome c and AIF (Apoptosis Inducing Factor) levels were measured by western blot and caspase 1, 3 and 9 activities were measured by colorimetric method. RESULTS: Cytochrome c and AIF levels were not altered, but all caspase activities were increased in female infant rabbits that exposed to 1800 MHz GSM-like RF signals when they reached 1 month of age and caspase 1 and caspase 3 levels were decreased in male infant rabbits that exposed to 1800 MHz GSM-like RF signals between 15th and 22nd days of the gestational period. Results showed that 1800 MHz GSM-like RF exposure might lead to apoptosis in infant rabbit's liver tissues. CONCLUSION: According to the results, we suggest that postnatal RF exposure causes caspase dependent apoptosis in female infant rabbits liver tissues (Tab. 1, Fig. 2, Ref. 27). Text in PDF www.elis.sk.

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“…The process of occurrence apoptosis can occur through two lines of the pathway, from the cell outside (extrinsic) and from the mitochondrial stress (intrinsic). Both the extrinsic pathway and the intrinsic pathway will end in the execution phase by activating the caspase cascade which is the final path of apoptosis [29]. The anthraquinone group compounds are thought to cause apoptosis either through extrinsic or intrinsic pathways with the activation of caspase cascade [30].…”

Section: Advances In Health Sciences Research Volumementioning

confidence: 99%

Anticancer Activity of Eleutherine bulbosa (Mill.) Urb. Extract on WiDr Cell Line In Vitro

Lubis¹,

Ichwan²,

Mustofa³

et al. 2018

Proceedings of the 2nd Public Health International Conference (PHICo 2017)

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Extrinsic and Intrinsic Apoptosis Signal Pathway Review

Cited by 106 publications

References 59 publications

D-Galactose Causes Motor Coordination Impairment, and Histological and Biochemical Changes in the Cerebellum of Rats

D-Galactose Causes Motor Coordination Impairment, and Histological and Biochemical Changes in the Cerebellum of Rats

GSM-like radiofrequency exposure induces apoptosis via caspase-dependent pathway in infant rabbits

Anticancer Activity of Eleutherine bulbosa (Mill.) Urb. Extract on WiDr Cell Line In Vitro

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