Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization

Lashen, Hany; Ledger, William; Bernal, Andrés López; Barlow, David H.

doi:10.1093/humrep/14.3.712

Cited by 175 publications

(132 citation statements)

References 29 publications

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“…The impact of BMI on assisted reproductive treatments (ART), such as IVF and ICSI is conflicting, with some studies showing no effect [14], and others demonstrating a poor pregnancy outcome with a higher BMI. Two large meta-analyses looking at the impact of BMI on IVF outcomes found insufficient evidence to draw firm conclusions on the impact of BMI on live birth rate [15] …”

Section: Bmi and Ivf/icsimentioning

confidence: 99%

The Impact of Body Mass Index on Assisted Reproductive Treatments

Supramaniam¹,

Mittal²,

Lim³

2017

OJOG

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Multiparity amongst women with a body mass index (BMI) ≥ 30 Kg/m 2 is a common occurrence despite there being a known clear association with a decline in fecundity in women who are overweight or obese. These women, also pose further concerns, as they are at increased risk of antenatal complications such as preeclampsia and gestational diabetes. Over the years, a number of different modalities of fertility treatments have been tried and tested in this cohort of women to find the optimal treatment to improve their reproductive capacity. There has been an exponential increase in knowledge and understanding towards managing patients with a raised BMI, particularly through assisted reproductive treatments. Although the efficacies of various forms of fertility treatments have been shown to be affected by a rise in BMI, there is yet to be a definitive understanding as to the optimal management of these patients. The literature supports weight loss alone as an effective intervention in improving the reproductive capacity of women with a raised BMI with unexplained infertility. Furthermore, if live birth rate is taken as the desired outcome measure, then ovarian drilling and in vitro fertilisation (IVF) treatment have been shown to yield the best results in overweight and obese patients when comparisons are drawn to other interventions such as natural conception and treatment with clomiphene citrate.

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Section: Bmi and Ivf/icsimentioning

confidence: 99%

The Impact of Body Mass Index on Assisted Reproductive Treatments

Supramaniam¹,

Mittal²,

Lim³

2017

OJOG

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“…The association between obesity and miscarriage has been reported in a number of studies, both in the general population (38) as well as in women undergoing assisted reproductive techniques (ART) (39,40). A remarkable number of these studies show an increase in the prevalence of miscarriage in case of obesity (38,(41)(42)(43); however, there are studies that found no association between these two issues (40,44).…”

Section: Obesity and Miscarriagementioning

confidence: 99%

“…A remarkable number of these studies show an increase in the prevalence of miscarriage in case of obesity (38,(41)(42)(43); however, there are studies that found no association between these two issues (40,44). The link between obesity and miscarriage has been reported in both natural and assisted conceptions.…”

Section: Obesity and Miscarriagementioning

confidence: 99%

Impact of obesity on infertility in women

Dağ

Dilbaz

2015

J Turkish German Gynecol Assoc

216

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Review 111 IntroductionObesity, which is an important health issue, is a common problem among women of reproductive age. Obesity and overweight involves an abnormal and excessive fat accumulation that negatively affects the health of the body. According to the World Health Organization (WHO), if the body mass index (BMI) equals to or is greater than 25 kg/m 2 , it is considered overweight, whereas if the BMI equals to or is greater than 30 kg/m 2 , it is considered obesity (1). Obesity brings out many problems such as social, psychological, demographic, and health problems. It is related to increased health risks such as diabetes mellitus, hypertension, coronary heart disease, and osteoarthritis and is linked to various malignancies, particularly endometrium, breast, and colon cancers. Obesity also plays a significant role in reproductive disorders, particularly in women. It is associated with anovulation, menstrual disorders, infertility, difficulties in assisted reproduction, miscarriage, and adverse pregnancy outcomes. In obese women, gonadotropin secretion is affected because of the increased peripheral aromatization of androgens to estrogens. The insulin resistance and hyperinsulinemia in obese women leads to hyperandrogenemia. The sex hormone-binding globulin (SHBG), growth hormone (GH), and insulin-like growth factor binding proteins (IGFBP) are decreased and leptin levels are increased. Thus, the neuroregulation of the hypothalamic-pituitary-gonadal (HPG) axis deteriorates (2). These alterations may explain impaired ovulatory function and so reproductive health. Because of lower implantation and pregnancy rates, higher miscarriage rates, and increased maternal and fetal complications during pregnancy, obese women have a lower chance to give birth to a healthy newborn (3)(4)(5)(6). In this review, the effects of obesity on fertility and effective management of infertility in obese and overweight women is summarized. Epidemiology of obesityThe prevalence of obesity is increasing significantly worldwide. The International Obesity Task Force reported that 1,1 billion adults are overweight. They also reported that 312 million of them are obese (7). Approximately 3,4 million adults die each year because of health problems associated with obesity and being overweight. Of these, 44% of the problems are related to diabetes, 23% to ischemic heart disease, and between 7% and 41% to some malignancies associated with overweight and obesity (7). The prevelence of obesity has increased in developed countries because of a change in lifestyle, including reduced physical activity, changes in nutrition style, and an increased calorie intake (8). However, some other factors such as endocrine disorders, hormonal disorders, psychological disorders, and use of some drugs such as steroids and antidepressants may lead to obesity (9). The World Health Organization reported that 60% of women are overweight (≥25 kg/m 2 ) in the United States and most European countries and 30% of these are obese (≥30 kg/m 2 ) and 6% of these are mo...

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“…Obesity is often seen as potentially treatable threat to the success of assisted reproduction, and while patients are commonly advised to try to normalize their weight before undertaking in vitro fertilization (IVF), many find weight loss difficult (1). Couples with infertility often wonder whether lifestyle habits might compromise their ability to reproduce.…”

Section: Introductionmentioning

confidence: 99%

Body Mass Index, Follicle-Stimulating Hormone and Their Predictive Value in In Vitro Fertilization

Sator

Gruber

et al. 2004

J Assist Reprod Genet

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Purpose :The objective was to explore whether body mass and day 3 follicle-stimulating hormone have predictive value on odds of pregnancy after in vitro fertilisation. Few studies show that obesity produces a variety of alterations in the reproductive system, and that women with an elevation of day 3 FSH have declining ovarian function. Methods : The data of one-hundred-seventy-one women who underwent a standard regime of controlled ovarian hyperstimulation was analyzed with particular reference to variations in body mass and hormone levels. Results : By raising BMI and FSH (mIU/mL) by one unit, the odds for pregnancy were decreased by the respective factors 0.84 (95% confidence interval 0.73-0.97) and 0.77 (95% confidence interval 0.59-1.00).Conclusions : The results demonstrate that for the purpose of raising the odds of pregnancy BMI should be reduced. A low FSH value may cause the same effect. Nontheless, obesity and hormonal function may be independent risk factors for failure in assisted reproduction.

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Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization

Cited by 175 publications

References 29 publications

The Impact of Body Mass Index on Assisted Reproductive Treatments

The Impact of Body Mass Index on Assisted Reproductive Treatments

Impact of obesity on infertility in women

Body Mass Index, Follicle-Stimulating Hormone and Their Predictive Value in In Vitro Fertilization

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