2008
DOI: 10.1002/cbic.200800489
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Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3

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Cited by 53 publications
(55 citation statements)
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“…The great majority of GSK-3 inhibitors are small molecules from organic synthesis but also marine natural compounds have produced different interesting leads [61,62]. Some peptides and organometallic compounds have also been studied in the search of a safe and effective GSK-3 inhibitor with good pharmacokinetic profile [63,64].…”
Section: Gsk-3 and Gsk-3 Inhibitorsmentioning
confidence: 99%
“…The great majority of GSK-3 inhibitors are small molecules from organic synthesis but also marine natural compounds have produced different interesting leads [61,62]. Some peptides and organometallic compounds have also been studied in the search of a safe and effective GSK-3 inhibitor with good pharmacokinetic profile [63,64].…”
Section: Gsk-3 and Gsk-3 Inhibitorsmentioning
confidence: 99%
“…With the metallopyridocarbazole serving as the pharmacophoric model, half-sandwich scaffolds (e.g., EA1, HB1052) or truly octahedral complexes (e.g., FL411, HB806) (Fig. 3) were developed [31][32][33][34][35][36][37][38][39][40][41][42]. For example, cyclopentadienyl-CO half-sandwich Organometallics as Structural Scaffolds for Enzyme Inhibitor Designcomplexes were identified as privileged lead structures for obtaining highly potent and selective inhibitors for the protein kinases GSK-3 and Pim-1 [31, 32, 34-36, 39, 41].…”
Section: Staurosporine As An Inspiration For Organometallic Inhibitorsmentioning
confidence: 99%
“…Currently, seven structures of ruthenium half-sandwich complexes with protein kinases are available in the protein databank, four with Pim-1 (2BZH, 2BZI, 2OI4, 2BZJ), one with Pim-2 (2IWI), one with GSK-3b (2JLD), and one with PAK-1 (3FY0) [31,36,37,39]. In addition, a cocrystal structure of an osmium half-sandwich complex with Pim-1 was published recently (3BWF) [38].…”
Section: Crystal Structures Of Organometallic Compounds Bound To the mentioning
confidence: 99%
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