Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage

Stratton, Dan; Malibha-Pinchbeck, Memory; Inal, Jameel M.

doi:10.1016/j.bbrc.2022.08.035

Cited by 6 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, The Center for Disease Control and Prevention classifies airline crew members as "radiation workers" [92,93] together with ICEMAN project [94]. "The characteristic reaction to electromagnetic radiation consists of tightening in the fascia surrounding the muscles, which in turn causes biochemical failure of the body [75,95], in particular, disruption of the functioning of cell membranes" [96], changing the probability of ion-channel on/off switching events [97]; this compression, stressful pressure on tissue can active mast cells to release bigger doses of histamine, and its higher level in blood can create clots in the veins (often occurs after flights), causing poor transportation of oxygen to organs, tiredness, headache, sleep disorders, drowsiness, and other symptoms similar to jet lag [98]. Those effects can be very dangerous during airplane flights and space exploration missions [99][100][101][102][103], together with sleep deprivation, which can double error rates [8]; moreover, another study shows that driving tired or sleepy is as dangerous as drunk-driving [104,105].…”

Section: Stress In the Shift Work Of A Pilots Astronauts Flight Contr...mentioning

confidence: 99%

Reduction of Stress and Jet Lag, Improvement of Well-Being, Sleep Quality and Body-Mind Regeneration by Vinci Power Nap® Neuroarchitecture System: Innovative Solution for Leaders, Employees, Travelers

Filcek,

Vats

2024

Sleep Medicine - Asleep or Awake?

View full text Add to dashboard Cite

The Vinci Power Nap® system is a cutting-edge tool for reducing stress and jet lag effects associated with air travel, allowing for quick body–mind regeneration and improving well-being and the quality of night’s sleep. Power naps in a specially designed environment based on interdisciplinary science, can restore homeostasis and work–life balance, release stress and tensions, strengthens focus and efficiency, and recover energy for life to many overtired leaders, employees, and people with sleep disorders. Helpful in the therapy for hypersensitive people, after trauma, in depression, with oncological experiences, and many other diseases. The research made in UN projects at COP24 on leaders, travelers, and UNICEF Ukraine’s refugees show extraordinary relaxing properties, harmonizing sleep patterns and internal vital parameters (breath, heartbeat, and brain waves) thanks to zero gravity position, pulsating touch, frequency swinging, calming all senses and neuroarchitectural external conditions. Sleep is the basis of our psychophysical and immune regeneration and preventing errors resulting from stress and fatigue. The Vinci Power Nap® system is crucial for hotels and airports due to its ability to reduce discomfort associated with jet lag, providing great help to travelers such as business leaders, pilots, doctors, drivers, athletes, workers, soldiers, astronauts, tourists, etc.

show abstract

Section: Stress In the Shift Work Of A Pilots Astronauts Flight Contr...mentioning

confidence: 99%

Reduction of Stress and Jet Lag, Improvement of Well-Being, Sleep Quality and Body-Mind Regeneration by Vinci Power Nap® Neuroarchitecture System: Innovative Solution for Leaders, Employees, Travelers

Filcek,

Vats

2024

Sleep Medicine - Asleep or Awake?

View full text Add to dashboard Cite

show abstract

“…The effects of low-frequency dynamic magnetic fields (LF DMF) on cells are complex and depend on various factors, such as the type of cells, field frequency, intensity and duration of exposure, and the presence of various additives. Extremely LF DMF (<1 kHz) on the order of mT are known to contribute to the increased cellular uptake of non-magnetic drugs such as methotrexate [38] and doxorubicin [39]. It was proposed that membrane-charged lipids could align along the magnetic field vector, resulting in the formation of transient membrane pores or damage large enough to allow medium-sized molecules to pass through them.…”

Section: Introductionmentioning

confidence: 99%

Low-Frequency Dynamic Magnetic Fields Decrease Cellular Uptake of Magnetic Nanoparticles

Ivanova,

Chmelyuk,

Nikitin

et al. 2024

Magnetochemistry

View full text Add to dashboard Cite

Magnetic nanoparticles have gained attention as a potential structure for therapy and diagnosing oncological diseases. The key property of the magnetic nanoparticles is the ability to respond to an external magnetic field. It is known that magnetofection causes an increase in the cellular uptake of RNA and DNA in complexes with magnetic nanoparticles in the presence of a permanent magnetic field. However, the influence of a dynamic magnetic field on the internalization of MNPs is not clear. In this work, we propose the idea that applying external low-frequency dynamic magnetic fields may decrease the cellular uptake, such as macrophages and malignant neuroblastoma. Using fluorescence microscopy and atomic emission spectroscopy, we found that oscillating magnetic fields decreased the cellular uptake of magnetic nanoparticles compared to untreated cells by up to 46%. In SH-SY5Y tumor cells and macrophage RAW264.7 cells, the absolute values of Fe per cell differed by 0.10 pg/cell and 0.33 pg/cell between treated and untreated cells, respectively. These results can be applied in the control of the cellular uptake in different areas of biomedicine.

show abstract

“…All three cell lines employed have been used in several studies as models to assess the biological effects of EMF exposure. and its impact on epigenetic regulation and cellular homeostasis [39,40,[42][43][44][45][46][47]. In particular, since it had been suspected that radiofrequency exposure could increase the incidence of brain and nervous system dysfunction [1], we used BE(2)C and SH-SY5Y neuroblastoma cell lines, which show biochemical characteristics of neuron cells [48] and have often been employed as in vitro models of neuronal function and pathology [49,50].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation

Ravaioli

Bacalini

Giuliani

et al. 2023

IJMS

View full text Add to dashboard Cite

A large body of evidence indicates that environmental agents can induce alterations in DNA methylation (DNAm) profiles. Radiofrequency electromagnetic fields (RF-EMFs) are radiations emitted by everyday devices, which have been classified as “possibly carcinogenic”; however, their biological effects are unclear. As aberrant DNAm of genomic repetitive elements (REs) may promote genomic instability, here, we sought to determine whether exposure to RF-EMFs could affect DNAm of different classes of REs, such as long interspersed nuclear elements-1 (LINE-1), Alu short interspersed nuclear elements and ribosomal repeats. To this purpose, we analysed DNAm profiles of cervical cancer and neuroblastoma cell lines (HeLa, BE(2)C and SH-SY5Y) exposed to 900 MHz GSM-modulated RF-EMF through an Illumina-based targeted deep bisulfite sequencing approach. Our findings showed that radiofrequency exposure did not affect the DNAm of Alu elements in any of the cell lines analysed. Conversely, it influenced DNAm of LINE-1 and ribosomal repeats in terms of both average profiles and organisation of methylated and unmethylated CpG sites, in different ways in each of the three cell lines studied.

show abstract

Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage

Cited by 6 publications

References 28 publications

Reduction of Stress and Jet Lag, Improvement of Well-Being, Sleep Quality and Body-Mind Regeneration by Vinci Power Nap® Neuroarchitecture System: Innovative Solution for Leaders, Employees, Travelers

Reduction of Stress and Jet Lag, Improvement of Well-Being, Sleep Quality and Body-Mind Regeneration by Vinci Power Nap® Neuroarchitecture System: Innovative Solution for Leaders, Employees, Travelers

Low-Frequency Dynamic Magnetic Fields Decrease Cellular Uptake of Magnetic Nanoparticles

Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation

Contact Info

Product

Resources

About