Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia

Abstract

Magnetic field as ecological factor has influence on all living beings. The aim of this study was to determine if extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affects oxidative stress in the brain of gerbils submitted to 10-min global cerebral ischemia. After occlusion of both carotid arteries, 3-month-old gerbils were continuously exposed to ELF-MF for 7 days. Nitric oxide and superoxide anion production, superoxide dismutase activity and index of lipid peroxidation were examined in the forebrain cortex, striatum and hippocampus on the 7th (immediate effect of ELF-MF) and 14th day after reperfusion (delayed effect of ELF-MF). Ischemia per se increased oxidative stress in the brain on the 7th and 14th day after reperfusion. ELF-MF also increased oxidative stress, but to a greater extent than ischemia, only immediately after cessation of exposure. Ischemic gerbils exposed to ELF-MF had increased oxidative stress parameters on the 7th day after reperfusion, but to a lesser extent than ischemic or ELF-MF-exposed animals. On the 14th day after reperfusion, oxidative stress parameters in the brain of these gerbils were mostly at the control levels. Applied ELF-MF decreases oxidative stress induced by global cerebral ischemia and thereby reduces possible negative consequences which free radical species could have in the brain. The results presented here indicate a beneficial effect of ELF-MF (50 Hz, 0.5 mT) in the model of global cerebral ischemia.

Extremely low frequency electromagnetic field (ELF‐EMF) reduces oxidative stress and improves functional and psychological status in ischemic stroke patients

“…There are limited data supporting the antioxidant effect of ELF‐EMF, in particular its positive impact on improving the functioning connective tissue's cells [Sosnowski et al, ; Kurzeja et al, ]. We have observed an increase of SOD activity in the hemolysate, with results that are consistent with data presented by Rauš Balind et al []. Those authors demonstrated that ELF‐EMF decreased the level of oxidative stress in gerbil brains with induced global cerebral ischaemia, as demonstrated by amplified SOD activity [Rauš Balind et al, ].…”

Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

“…Alterations in inflammatory responses have also been observed, but how these activities affect human health remains unknown [23].…”

In Vitro and In Vivo Assessment of Magnetically Actuated Biomaterials and Prospects in Tendon Healing

“…PEMF is an FDA-approved therapy presenting benefices for the treatment of several musculoskeletal disorders, however there is controversy about the role of magnetic fields in oxidative stress. Some studies suggested that magnetic fields, accounting their strength and amplitude are endowed with the ability to generate potentially harmful ROS [29], while others demonstrated that magnetic fields selectively decreased the viability of malignant cells [30], reduced oxidative stress in the brain of Gerbils [31] and activated endogenous clearance mechanisms to remove ROS [16]. We found no differences in ROS production between static and magnetic conditions suggesting that environmental stress produced by magnetically actuated biomaterials is not perceived by hASCs as harmful.…”