Extremely low frequency electromagnetic fields and heat shock can increase microvesicle motility in astrocytes

Gölfert, F.; Höfer, Andreas; Thümmler, M; Bauer, H.‐D.; Funk, Richard

doi:10.1002/1521-186x(200102)22:2<71::aid-bem1008>3.0.co;2-i

Cited by 15 publications

(10 citation statements)

References 41 publications

(34 reference statements)

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“…Primary rat astrocytes were treated at 45°C for 10 min before 50 Hz MF exposure for 1 h at 100 µT. Increase in the microvesicle velocity was detected after both MF exposure and heat treatment alone, which was not modified by the combined treatments ( 72 ).…”

Section: Summary and Concluding Remarksmentioning

confidence: 99%

Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins?

Zeni

Simkó²,

Scarfì

et al. 2017

Front. Public Health

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It has been shown that magnetic fields in the extremely low frequency range (ELF-MF) can act as a stressor in various in vivo or in vitro systems, at flux density levels below those inducing excitation of nerve and muscle cells, which are setting the limits used by most generally accepted exposure guidelines, such as the ones published by the International Commission on Non-Ionizing Radiation Protection. In response to a variety of physiological and environmental factors, including heat, cells activate an ancient signaling pathway leading to the transient expression of heat shock proteins (HSPs), which exhibit sophisticated protection mechanisms. A number of studies suggest that also ELF-MF exposure can activate the cellular stress response and cause increased HSPs expression, both on the mRNA and the protein levels. In this review, we provide some of the presently available data on cellular responses, especially regarding HSP expression, due to single and combined exposure to ELF-MF and heat, with the aim to compare the induced effects and to detect possible common modes of action. Some evidence suggest that MF and heat can act as costressors inducing a kind of thermotolerance in cell cultures and in organisms. The MF exposure might produce a potentiated or synergistic biological response such as an increase in HSPs expression, in combination with a well-defined stress, and in turn exert beneficial effects during certain circumstances.

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Section: Summary and Concluding Remarksmentioning

confidence: 99%

Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins?

Zeni

Simkó²,

Scarfì

et al. 2017

Front. Public Health

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“…At the cellular level, ELF MFs, as well as heat shock, proved to increase microvescicle motility in astrocytes (Golfert et al 2001). It was observed that both sedimentation and aggregation of erythrocytes were MF-dependent (Lino and Okuda 2001).…”

Section: Introductionmentioning

confidence: 70%

Mechanisms of the target response to magnetic fields and their correlation with the biological complexity

Volpe

Eremenko

2007

Environmentalist

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The present contribution points to the mechanisms of bioresponse caused by magnetic fields, paying attention to their action not only at the ionic, molecular or macromolecular levels but also at the levels of cells, tissues and organisms. The significance of findings concerning the magnetic-field dependence of cell proliferation, necrosis or apoptosis and cell volume or membrane fluidity is judged by comparing the results obtained in a solenoid, where a magnetic field can be added to the geomagnetic field, with those obtained in a magnetically shielded room, where the magnetic fields can be attenuated or null. This comparative criterion was particularly required when the differences found between the data provided by experimental samples and the data provided by control samples are small per se, as observed in estimating the magnetic-field dependence of expression of single genes or the magnetic-field dependence of total genome replication, transcription and translation. The report analyzes the magnetic-field dependence of the interactions between host animal cells and infecting bacteria and, in the framework of studies on the origin and adaptation of life on Earth, theoretical insights paving the way to elucidating the mechanisms of magnetic-field interactions with biosystems of different orders of organization are considered from the viewpoint of the ''biological windows'' thermodynamics. Thus, analogously to what is known for ionizing radiations, an inverse correlation emerged between the intensity of given magnetic fields and the biological complexity.

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“…At the cellular level, an MF-dependence of the membrane state was established through cytofluorimetry [81]. ELF MFs, as well as heat shock, proved to increase microvescicle motility in astrocytes [82]. Both sedimentation and aggregation of erythrocytes were MF-dependent [83].…”

Section: Biotargets Of Middle Complexity Exhibited a Moderate Mf-stabmentioning

confidence: 99%

A Theoretical Overview of Bioresponse to Magnetic Fields on the Earth’s Surface

Volpe¹

2014

IJG

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This survey points to the mechanisms of bioresponse caused by magnetic fields (MFs), paying attention to their action not only on ions, molecules and macromolecules, but also on cells, tissues and organisms. The significance of findings concerning the MF-dependence of cell proliferation, necrosis or apoptosis was judged by comparing the results obtained in a solenoid, where an MF can be added to the geomagnetic field (GMF), with those obtained in a magnetically shielded room, where the MFs can be attenuated or null. This comparative criterion was particularly appropriate when the differences detectable between the data provided by experimental samples and the data provided by control samples were rather small, as observed in estimating the MF-influence on total DNA replication, RNA transcription and polypeptide translation. The MF-induced inhibition of apoptosis was considered as a risk potentially leading to accumulation of cancer cells. The analysis also surveyed the MF-dependence of the interactions between host animal cells and infecting bacteria. In relation to studies on the origin and adaptation of life on the Earth, theoretical insights paving the way to elucidating the MF-interactions with biostructures and biosystems of different orders of organization evaluated the possible involvement of the so-called "biological windows". Analogously to what is known for ionizing radiations, the efficiency of the applied MFs appeared to depend on the complexity of their biological targets.

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Extremely low frequency electromagnetic fields and heat shock can increase microvesicle motility in astrocytes

Cited by 15 publications

References 41 publications

Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins?

Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins?

Mechanisms of the target response to magnetic fields and their correlation with the biological complexity

A Theoretical Overview of Bioresponse to Magnetic Fields on the Earth’s Surface

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