Extremely Low Frequency Electromagnetic Fields Decrease Serum Levels of Interleukin-17, Transforming Growth Factor-β and Downregulate <i>Foxp3</i> Expression in the Spleen

Mahdavinejad, Leila; Alahgholi-Hajibehzad, Mahdi; Eftekharian, Mohammad Mahdi; Zaerieghane, Zohre; Salehi, Iraj; Hajilooi, Mehrdad; Mahaki, Hanie; Zamani, Alireza

doi:10.1089/jir.2018.0048

Cited by 16 publications

(16 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is shown that the effects of 50 Hz EMFs with 1-and 100-µT magnetic field flux density suppressed the serum level of IL-17 and expression of RORα, suggesting inhibitory effects of 50 Hz EMFs on inflammation. 28,30 In contrast, an in vivo study by Pena-Philippides, et al, investigated the effect of 50 Hz pulsed EMF with 0.1-µT magnetic field flux density was able to increase the expression of IL-9 and decrease the expression of IL-1α and TNF-α in ischemic brain damaged of C57BL/6 male mice. These effects indicated that 50 Hz pulsed EMF application could have a possible adjunctive treatment for stroke patients with down-regulation of major pro-inflammatory cytokines, IL-1α and TNF-α.…”

Section: Discussionmentioning

confidence: 99%

“…23 Furthermore, TGF-β along with IL-10, the signature cytokines of Treg cells, suppress the immune system and play role in prevention of inflammatory diseases; TGF-β does not change after exposure to 50 Hz EMFs. 28 Some studies indicate that IL-10 has a negative feedback on IL-9 production. For instance, IL-10 is significantly increased in IL-9-/-EAE mice compared with their wild type counterparts following immunization with myelin proteolipid protein.…”

Section: Discussionmentioning

confidence: 99%

“…The rats were immunized with HSA to activate naive CD4 + T cells and to shift them toward functional patterns of Th1, Th2, Th17, and Treg subsets formation. 28 On day 61, at the end of the exposure period, the rats were sacrificed with Electromagnetic Field and IL-9, IL-10, and TNF-α Levels…”

Section: Exposure Devicesmentioning

confidence: 99%

“…24,25 In our previous studies, the effects of 50 Hz EMFs were investigated on some cytokines levels such as IFN-γ, transforming growth factor-beta (TGF-β), IL-4, IL-6, IL-9, IL-10, IL-12, and IL-17 in pre-and post-immunization phases. [26][27][28] The current study was conducted to determine if exposure to 50 Hz EMFs with flux densities of 1, 100,…”

mentioning

confidence: 99%

See 3 more Smart Citations

Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α Levels

Mahaki

Jabarivasal

Sardanian

et al. 2020

Int J Occup Environ Med

Self Cite

View full text Add to dashboard Cite

Background: Extremely low-frequency electromagnetic fields (ELF-EMFs) are abundantly produced in modern societies. In recent years, interest in the possible effects of ELF-EMFs on the immune system has progressively increased. Objective: To examine the effects of ELF-EMFs with magnetic flux densities of 1, 100, 500, and 2000 µT on the serum levels of interleukin (IL)-9, IL-10, and tumor necrosis factor-alpha (TNF-α). Methods: 80 adult male rats were exposed to ELF-EMFs at a frequency of 50 Hz for 2 h/day for 60 days. The serum cytokines were measured at two phases of pre- and post-stimulation of the immune system by human serum albumin (HSA). Results: Serum levels of IL-9 and TNF-α, as pro-inflammatory cytokines, were decreased due to 50 Hz EMFs exposure compared with the controls in the pre- and post-stimulation phases. On the contrary, exposures to 1 and 100 µT 50 Hz EMFs increased the levels of antiinflammatory cytokine, and IL-10 only in the pre-stimulation phase. In the post-stimulation phase, the mean level of serum IL-10 was not changed in the experimental groups. Conclusion: The magnetic flux densities of 1 and 100 µT 50 Hz EMFs had more immunological effects than EMFs with higher densities. Exposure to 50 Hz EMFs may activate anti-inflammatory effects in rats, by down-modulation of pro-inflammatory cytokines (IL-9 and TNF-α) and induction of the anti-inflammatory cytokine (IL-10).

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Exposure Devicesmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α Levels

Mahaki

Jabarivasal

Sardanian

et al. 2020

Int J Occup Environ Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cytotoxicity data were analyzed using one‐way analysis of variance (ANOVA) followed by post hoc Tukey's test. [ 15 ]…”

Section: Methodsmentioning

confidence: 99%

Synthesis, anticancer activity, and β‐lactoglobulin binding interactions of multitargeted kinase inhibitor sorafenib tosylate (SORt) using spectroscopic and molecular modelling approaches

et al. 2020

Self Cite

View full text Add to dashboard Cite

Sorafenib tosylate (SORt) is an oral multikinase inhibitor used for treatment of advanced renal cell, liver, and thyroid cancers. In this study, this drug was synthesized and its antiproliferative activities against HCT116 and CT26 cells were assessed. The interaction of SORt with β‐lactoglobulin (BLG) was studied using different fluorescence techniques, circular dichroism (CD), zeta potential measurements, and docking simulation. The results of infrared (IR), mass, HNMR, and CNMR spectra demonstrated that the drug was produced with high quality, purity, and efficiency. SORt showed potent cytotoxicity against HCT116 and CT26 cells with IC50 of 8.12 and 5.42 μM, respectively. For BLG binding of SORt, the results showed that static quenching was the cause of the high affinity drug–protein interaction. Three‐dimensional fluorescence and synchronous spectra indicated that SORt conformation was changed at different levels. CD suggested that the α‐helix content remained almost constant in the BLG–SORt complex, whereas random coil content decreased. Zeta potential values of BLG were more positive after binding with SORt, due to electrostatic interactions between BLG and SORt. Thermodynamic parameters confirmed van der Waals and hydrogen bond interactions in the complex formation. Molecular modelling predicted the presence of hydrogen bonds and electrostatic forces in the BLG–SORt system, which was consistent with the experimental results.

show abstract

The Effects of Antioxidant Vitamins on Proinflammatory Cytokines and Some Biochemical Parameters of Power Plant Workers: A Double‐Blind Randomized Controlled Clinical Trial

Hosseinabadi

Khanjani

Norouzi

et al. 2020

Bioelectromagnetics

View full text Add to dashboard Cite

Some epidemiological studies have suggested that exposure to extremely low-frequency magnetic fields (ELF-MFs) can affect the immune system. This study aimed to investigate the effects of antioxidant vitamin consumption on proinflammatory cytokines and biochemical parameters changes. In this randomized, controlled double-blinded trial study, power plant workers exposed to ELF-MFs were enrolled based on inclusion criteria. Ninety-one eligible subjects were randomly divided into four groups: the first group (400 units of vitamin E/day), second group (1,000 mg of vitamin C/day), third group (400 units of vitamin E and 1,000 mg of vitamin C/day), and control group. The intervention was conducted for 3 months. Proinflammatory cytokines interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), and biochemical parameters (fasting blood sugar, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol [HDL-c], total protein, and albumin) were measured among the participants' serums, before and after the intervention. The mean level of IL-6 in all vitaminreceiving groups, the mean level of IL-1β in vitamin C and E&C groups, and the mean level of TNF-α in the vitamin C group, decreased significantly after intervention. The arithmetic means of the effect sizes for IL-1β, IL-6, and TNF-α were 0.71, 0.57, and 0.2, respectively. The level of HDL-c in the vitamin E and vitamin E&C groups and the level of triglyceride in the vitamin C group significantly increased after the intervention. Taking antioxidant vitamins can prevent an increase of proinflammatory cytokines induced by prolonged exposure to ELF

show abstract

Extremely Low Frequency Electromagnetic Fields Decrease Serum Levels of Interleukin-17, Transforming Growth Factor-β and Downregulate Foxp3 Expression in the Spleen

Cited by 16 publications

References 17 publications

Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α Levels

Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α Levels

Synthesis, anticancer activity, and β‐lactoglobulin binding interactions of multitargeted kinase inhibitor sorafenib tosylate (SORt) using spectroscopic and molecular modelling approaches

The Effects of Antioxidant Vitamins on Proinflammatory Cytokines and Some Biochemical Parameters of Power Plant Workers: A Double‐Blind Randomized Controlled Clinical Trial

Contact Info

Product

Resources

About