Extremely low frequency electromagnetic field
reduces oxidative stress during the rehabilitation
of post-acute stroke patients

Cichoń, Natalia; Rzeźnicka, Paulina; Bijak, Michał; Miller, Elżbieta; Miller, Sergiusz; Saluk‐Bijak, Joanna

doi:10.17219/acem/73699

Cited by 18 publications

(16 citation statements)

References 36 publications

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“…Studies on the clinical applications of ELF-EMFs have reported protection against hypoxia and myocardial damage, and increased survival following ischemia-reperfusion [19,20]. ELF-EMFs have also been reported to be effective in enhancing osteogenesis and chondrogenesis in human skeletal stem cells/human bone marrow stromal cells (hSSCs/hBMSCs), with no documented negative effects [21,22].…”

Section: Introductionmentioning

confidence: 99%

Human Gingival Fibroblasts Exposed to Extremely Low-Frequency Electromagnetic Fields: In Vitro Model of Wound-Healing Improvement

Costantini

Sinjari

D’Angelo

et al. 2019

IJMS

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Several clinical studies have suggested the impact of sinusoidal and pulsed electromagnetic fields in quickening wound repair processes and tissue regeneration. The clinical use of extremely low-frequency electromagnetic fields could represent a novel frontier in tissue repair and oral health, with an interesting clinical perspective. The present study aimed to evaluate the effect of an extremely low-frequency sinusoidal electromagnetic field (SEMF) and an extremely low-frequency pulsed electromagnetic field (PEMF) with flux densities of 1 mT on a model of oral healing process using gingival fibroblasts. An in vitro mechanical injury was produced to evaluate wound healing, migration, viability, metabolism, and the expression of selected cytokines and protease genes in fibroblasts exposed to or not exposed to the SEMF and the PEMF. Interleukin 6 (IL-6), transforming growth factor beta 1 (TGF-β), metalloproteinase 2 (MMP-2), monocyte chemoattractant protein 1 (MCP-1), inducible nitric oxide synthase (iNOS), and heme oxygenase 1 (HO-1) are involved in wound healing and tissue regeneration, favoring fibroblast proliferation, chemotaxis, and activation. Our results show that the exposure to each type of electromagnetic field increases the early expression of IL-6, TGF-β, and iNOS, driving a shift from an inflammatory to a proliferative phase of wound repair. Additionally, a later induction of MMP-2, MCP-1, and HO-1 was observed after electromagnetic field exposure, which quickened the wound-healing process. Moreover, electromagnetic field exposure influenced the proliferation, migration, and metabolism of human gingival fibroblasts compared to sham-exposed cells. This study suggests that exposure to SEMF and PEMF could be an interesting new non-invasive treatment option for wound healing. However, additional studies are needed to elucidate the best exposure conditions to provide the desired in vivo treatment efficacy.

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Section: Introductionmentioning

confidence: 99%

Human Gingival Fibroblasts Exposed to Extremely Low-Frequency Electromagnetic Fields: In Vitro Model of Wound-Healing Improvement

Costantini

Sinjari

D’Angelo

et al. 2019

IJMS

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“…Moreover, ELF-EMF promotes cell proliferation, protein synthesis, ion transport, and changes in cellular signal transmission ( Li, 2017 ). Our previous studies have shown that ELF-EMF therapy reduces oxidative stress during rehabilitation of post-acute stroke patients ( Cichoń et al, 2017a , 2018 ). Additionally, our recent research, for the first time focused on the effect of ELF-EMF on the potential factors of brain plasticity, indicate that ELF-EMF therapy increases the generation and metabolism of NO – neurotransmitter regulating neurogenesis, and synaptic plasticity ( Cichoń et al, 2017b ).…”

Section: Introductionmentioning

confidence: 99%

Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients

Cichoń

Bijak

Czarny

et al. 2018

Front. Aging Neurosci.

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Background: Neuroplasticity ensures the improvement of functional status in patients after stroke. The aim of this study was to evaluate the effect of extremely low-frequency electromagnetic field therapy (ELF-EMF) on brain plasticity in the rehabilitation of patients after stroke.Methods: Forty-eight patients were divided into two groups underwent the same rehabilitation program, but in the study group, the patients additionally were exposed to a standard series of 10 ELF-EMF treatments. To determine the level of neuroplasticity, we measured the plasma level of the brain-derived neurotrophic factor (BDNF), the vascular-endothelial growth factor, as well as BDNF mRNA expression. Additionally, we determined the molecule levels for hepatocyte growth factor, stem cell factor, stromal cell-derived factor 1α, nerve growth factor β, and leukemia inhibitory factor, using 5plex cytokine panel in plasma. After 4 weeks, during which patients had undergone neurorehabilitation and neurological examinations, we assessed functional recovery using the Barthel Index, Mini-Mental State Examination (MMSE), Geriatric Depression Scale, National Institutes of Health Stroke Scale (NIHSS), and the modified Rankin Scale (mRS).Results: We observed that ELF-EMF significantly increased growth factors and cytokine levels involved in neuroplasticity, as well as promoted an enhancement of functional recovery in post-stroke patients. Additionally, we presented evidence that these effects could be related to the increase of gene expression on the mRNA level. Moreover, a change of BDNF plasma level was positively correlated with the Barthel Index, MMSE, and negatively correlated with GDS.Conclusion: Extremely low-frequency electromagnetic field therapy improves the effectiveness of rehabilitation of post-stroke patients by improving neuroplasticity processes.

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“…High magnetic intensity, 5 or 7 mT of 40 Hz ELF-MF, significantly increased enzymatic antioxidant activity as compared to results obtained before treatment. The results were correlated with the improvement in functional and mental status of post-stroke patients [86,87]. These data show that ELF-MF is a factor that may both increase the production of ROS and activate organisms' antioxidant machinery in humans.…”

Section: Oxidative Stress and Antioxidant Statusmentioning

confidence: 54%

Extremely Low-Frequency Magnetic Field as a Stress Factor—Really Detrimental?—Insight into Literature from the Last Decade

Klimek

Rogalska

2021

Brain Sciences

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Biological effects of extremely low-frequency magnetic field (ELF-MF) and its consequences on human health have become the subject of important and recurrent public debate. ELF-MF evokes cell/organism responses that are characteristic to a general stress reaction, thus it can be regarded as a stress factor. Exposure to ELF-MF “turns on” different intracellular mechanisms into both directions: compensatory or deleterious ones. ELF-MF can provoke morphological and physiological changes in stress-related systems, mainly nervous, hormonal, and immunological ones. This review summarizes the ELF-MF-mediated changes at various levels of the organism organization. Special attention is placed on the review of literature from the last decade. Most studies on ELF-MF effects concentrate on its negative influence, e.g., impairment of behavior towards depressive and anxiety disorders; however, in the last decade there was an increase in the number of research studies showing stimulating impact of ELF-MF on neuroplasticity and neurorehabilitation. In the face of numerous studies on the ELF-MF action, it is necessary to systematize the knowledge for a better understanding of the phenomenon, in order to reduce the risk associated with the exposure to this factor and to recognize the possibility of using it as a therapeutic agent.

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Extremely low frequency electromagnetic field reduces oxidative stress during the rehabilitation of post-acute stroke patients

Cited by 18 publications

References 36 publications

Human Gingival Fibroblasts Exposed to Extremely Low-Frequency Electromagnetic Fields: In Vitro Model of Wound-Healing Improvement

Human Gingival Fibroblasts Exposed to Extremely Low-Frequency Electromagnetic Fields: In Vitro Model of Wound-Healing Improvement

Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients

Extremely Low-Frequency Magnetic Field as a Stress Factor—Really Detrimental?—Insight into Literature from the Last Decade

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