Extremely High Frequency Electromagnetic Irradiation in Combination with Antibiotics Enhances Antibacterial Effects on Escherichia coli

Torgomyan, Heghine; Tadevosyan, Hasmik; Trchоunian, Armen

doi:10.1007/s00284-010-9811-2

Cited by 26 publications

(29 citation statements)

References 16 publications

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“…However, for Wi-Fi exposure, this significant change was observed at 4.5 hours and for the RF simulator at the 12 th hour. Many studies have demonstrated that the bacterial response to electromagnetic fields is dependent on several factors including: intensity, frequency, duration of exposure, and other physicochemical properties of the fields (22,37,38). As mentioned, the frequency of Wi-Fi router was 2.4 GHz and RF simulator was 900 MHz, maximum bacterial response to this radiation occurred at different times, which was related to their frequencies.…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial resistance to one or more antibiotics occurs by various mechanisms (24)(25)(26). In this way, EMFs as an environmental agent could influence cellular responses such as antimicrobial susceptibility through different pathways (4,20,22,23,27). The aim of the present study was to evaluate the antimicrobial susceptibility of K. pneumoniae under 900 MHz radiofrequency radiations condition.…”

Section: Introductionmentioning

confidence: 99%

“…due to overuse of antibiotics in chemotherapy, food source, agriculture, and animal husbandry (20)(21)(22)(23). Bacterial resistance to one or more antibiotics occurs by various mechanisms (24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the 900 MHz Radiofrequency Radiation Effects on the Antimicrobial Susceptibility and Growth Rate of Klebsiella pneumoniae

et al. 2017

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Introduction: Drug resistance to one or more antibiotics is mainly believed to be a serious threat to global public health which occurs by various mechanisms. The electromagnetic field as a nonchemical tool is capable of altering the antimicrobial susceptibility of bacteria. The aim of this study is the evaluation of the antimicrobial susceptibility of the Klebsiella pneumoniae to antibiotics before and after exposure to 900 MHz radiofrequency (RF) radiation produced by a mobile phone.Methods: Antimicrobial susceptibility of the bacteria to antibiotics disks were performed after exposure to 900 MHz radiofrequency radiation. Antimicrobial susceptibility was carried out by Kirby-Bauer and the inhibition zone of each antibiotic disk was measured (as mean). Additionally, growth variations under exposure were recorded and an outgrowth curve was drawn.Results: Based on the results, after 12 hours of exposure to 900MHz radiofrequency, there was observed a maximum increase in the sensitivity of K. pneumoniae and shown that radiofrequency (RF) radiation can change antimicrobial sensitivity significantly (P < 0.05). Also, the radiofrequency radiation effect on the bacterial proliferation was evaluated and showed that exposure enables the bacteria to grow faster in the exponential phase than the non-exposed bacteria. Conclusions:The findings of the study indicated that the sensitivity of K. pneumoniae was significantly increased to the various antibiotics after 12 hours of exposure to 900 MHz radiofrequency radiation. These observations could be interpreted by the concept of non-linearity in the responses of K. pneumoniae to different antibiotics after exposure to electromagnetic radiofrequency radiation and can be useful in the management of serious infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of the 900 MHz Radiofrequency Radiation Effects on the Antimicrobial Susceptibility and Growth Rate of Klebsiella pneumoniae

et al. 2017

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“…Alterations in cell membrane properties such as bioenergetics, transport and enzyme activity by extremely high‐frequency EMI (Trchounian et al ., ; Tadevosyan et al ., ; Torgomyan et al ., ) might serve as a molecular cellular basis for EMI effects on bacteria, and confirm the membranotropic mechanism of the action of EMI. The H + ‐translocating F 0 F 1 ‐ATPase, which is the main membrane bioenergetic component, is among probable targets of EMI (Tadevosyan et al ., ; Tadevosyan & Trchounian, ; Torgomyan et al ., , b).…”

Section: Introductionmentioning

confidence: 64%

“…Previous studies in our laboratory have demonstrated that coherent extremely high frequency EMI decreases the growth rate of Enterococcus hirae (Ohanyan et al ., ) and Escherichia coli (Trchounian et al ., ; Tadevosyan et al ., , ; Torgomyan & Trchounian, ; Torgomyan et al ., , b). Antibacterial effects depend on the intensity of irradiation, exposure duration, the phase and conditions of bacterial growth, the composition and pH of the growth medium, and characteristics of the bacterial strains.…”

Section: Introductionmentioning

confidence: 99%

Electromagnetic irradiation of Enterococcus hirae at low-intensity 51.8- and 53.0-GHz frequencies: changes in bacterial cell membrane properties and enhanced antibiotics effects

Torgomyan

Ohanyan

Blbulyan

et al. 2012

FEMS Microbiol Lett

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Exposure to electromagnetic irradiation (EMI) of 51.8 and 53.0 GHz and low intensity (flux capacity of 0.06 mW cm(-2) ) for 1 h markedly decreased the energy-dependent H(+) and K(+) transport across membranes of Enterococcus hirae ATCC 9790. After EMI, there was also a significant decrease of overall and N,N'-dicyclohexylcarbodiimide (DCCD)-sensitive ATPase activity of the membrane vesicles. These measures were considerably lower at 53.0 GHz. EMI in combination with different antibiotics, such as ceftriaxone and kanamycin at their minimal inhibitory concentrations (100 and 200 μM, respectively), enhanced bacterial cell growth and altered their membrane transport properties. Total H(+) efflux was most sensitive to ceftriaxone but DCCD-inhibited H(+) efflux and total K(+) influx were sensitive to kanamycin. The results indicate that cell membrane proteins could be a target in the action of EMI and enhanced antibacterial effects in combination with antibiotics. The DCCD-sensitive F(0) F(1) -ATPase or this ATPase in combination with K(+) uptake protein probably plays a key role in these effects.

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A systematic review on cellular responses of Escherichia coli to nonthermal electromagnetic irradiation

Askaripour,

Żak

2023

Bioelectromagnetics

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Investigation of Escherichia coli under electromagnetic fields is of significance in human studies owing to its short doubling time and human‐like DNA mechanisms. The present review aims to systematically evaluate the literature to conclude causality between 0 and 300 GHz electromagnetic fields and biological effects in E. coli. To that end, the OHAT methodology and risk of bias tool were employed. Exponentially growing cells exposed for over 30 min at temperatures up to with fluctuations below were included from the Web‐of‐Knowledge, PubMed, or EMF‐Portal databases. Out of 904 records identified, 25 articles satisfied the selection criteria, with four excluded during internal validation. These articles examined cell growth (11 studies), morphology (three studies), and gene regulation (11 studies). Most experiments (85%) in the included studies focused on the extremely low‐frequency (ELF) range, with 60% specifically at 50 Hz. Changes in growth rate were observed in 74% of ELF experiments and 71% of radio frequency (RF) experiments. Additionally, 80% of ELF experiments showed morphology changes, while gene expression changes were seen in 33% (ELF) and 50% (RF) experiments. Due to the limited number of studies, especially in the intermediate frequency and RF ranges, establishing correlations between EMF exposure and biological effects on E. coli is not possible.

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Extremely High Frequency Electromagnetic Irradiation in Combination with Antibiotics Enhances Antibacterial Effects on Escherichia coli

Cited by 26 publications

References 16 publications

Evaluation of the 900 MHz Radiofrequency Radiation Effects on the Antimicrobial Susceptibility and Growth Rate of Klebsiella pneumoniae

Evaluation of the 900 MHz Radiofrequency Radiation Effects on the Antimicrobial Susceptibility and Growth Rate of Klebsiella pneumoniae

Electromagnetic irradiation of Enterococcus hirae at low-intensity 51.8- and 53.0-GHz frequencies: changes in bacterial cell membrane properties and enhanced antibiotics effects

A systematic review on cellular responses of Escherichia coli to nonthermal electromagnetic irradiation

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