Extreme thrombocytosis after orthopaedic surgery

Bunting, Robert; Doppelt, SH; Ls, Lavine

doi:10.1302/0301-620x.73b4.2071662

Cited by 13 publications

(14 citation statements)

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“…Although the occurrence of heparin-induced thrombocytopenia in patients managed with low-molecularweight heparin is extremely rare compared with that in patients managed with unfractionated heparin, and the prevalence has not been clearly established 5,10,25,30 , patients were dropped from the study if the platelet count, which was obtained each day for the first three days after the operation, decreased to less than 100 × 10 9 per liter.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Enoxaparin and Warfarin for the Prevention of Venous Thromboembolic Disease After Total Hip Arthroplasty. Evaluation During Hospitalization and Three Months After Discharge*

Colwell

Collis

Paulson

et al. 1999

The Journal of Bone & Joint Surgery

252

163

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Background: Venous thromboembolic disease in the form of deep venous thrombosis and pulmonary embolism is a major risk after a total hip arthroplasty. Enoxaparin, a low-molecular-weight heparin, has been shown to reduce the prevalence of deep venous thrombosis after total hip arthroplasty. Warfarin, an orally administered anticoagulant, has been used historically to reduce the risk of deep venous thrombosis after total hip arthroplasty. Methods: We compared enoxaparin and adjusteddose warfarin with respect to their safety and their efficacy in the prevention of clinically important venous thromboembolic disease, defined as distal or proximal deep venous thrombosis or pulmonary embolism, or both, during hospitalization after total hip arthroplasty. We also evaluated the prevalence of complications and mortality from venous thromboembolic disease within three months after discharge. Results: Three thousand and eleven patients at 156 centers were randomly assigned to prophylactic treatment with injection of enoxaparin or oral administration of adjusted-dose warfarin during hospitalization. During the study, fifty-five (3.6 percent) of the 1516 patients who were managed with enoxaparin and fifty-six (3.7 percent) of the 1495 patients who were managed with warfarin had venous thromboembolic gene, Oregon 97401.

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Section: Methodsmentioning

confidence: 99%

Comparison of Enoxaparin and Warfarin for the Prevention of Venous Thromboembolic Disease After Total Hip Arthroplasty. Evaluation During Hospitalization and Three Months After Discharge*

Colwell

Collis

Paulson

et al. 1999

The Journal of Bone & Joint Surgery

252

163

View full text Add to dashboard Cite

show abstract

“…This is because HIT typically begins 5 to 10 days after starting heparin therapy, 2 thus coinciding in postoperative patients who receive antithrombotic prophylaxis with heparin in the period in which the platelet count is rising to levels well above the preoperative values (postoperative thrombocytosis). 3,4 Additionally, there are reports 5-9 that thrombotic events can complicate HIT during a platelet count fall that does not necessarily attain thrombocytopenic levels, as conventionally defined.…”

mentioning

confidence: 99%

An Improved Definition of Immune Heparin-Induced Thrombocytopenia in Postoperative Orthopedic Patients

Warkentin

Roberts²,

Hirsh³

et al. 2003

Arch Intern Med

302

276

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“…The relevance of this event is not clear yet [40-42]. Despite this fact, the parameters were within physiological standards for these animals (574–1253 × 10 3 cells/μL) [39].…”

Section: Resultsmentioning

confidence: 99%

Systemic effects induced by intralesional injection of ω-conotoxin MVIIC after spinal cord injury in rats

Oliveira

Silva

Lavor

et al. 2014

J Venom Anim Toxins incl Trop Dis

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BackgroundCalcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. MVIIC neuroprotective effects analyzed in in vitro models of brain and spinal cord ischemia suggest a potential role of this toxin in preventing injury after spinal cord trauma. However, previous clinical studies with MVIIC demonstrated that clinical side effects might limit the usefulness of this drug and there is no research on its systemic effects. Therefore, the present study aimed to investigate the potential toxic effects of MVIIC on organs and to evaluate clinical and blood profiles of rats submitted to spinal cord injury and treated with this marine toxin. Rats were treated with placebo or MVIIC (at doses of 15, 30, 60 or 120 pmol) intralesionally following spinal cord injury. Seven days after the toxin administration, kidney, brain, lung, heart, liver, adrenal, muscles, pancreas, spleen, stomach, and intestine were histopathologically investigated. In addition, blood samples collected from the rats were tested for any hematologic or biochemical changes.ResultsThe clinical, hematologic and biochemical evaluation revealed no significant abnormalities in all groups, even in high doses. There was no significant alteration in organs, except for degenerative changes in kidneys at a dose of 120 pmol.ConclusionsThese findings suggest that MVIIC at 15, 30 and 60 pmol are safe for intralesional administration after spinal cord injury and could be further investigated in relation to its neuroprotective effects. However, 120 pmol doses of MVIIC may provoke adverse effects on kidney tissue.

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Extreme thrombocytosis after orthopaedic surgery

Cited by 13 publications

References 0 publications

Comparison of Enoxaparin and Warfarin for the Prevention of Venous Thromboembolic Disease After Total Hip Arthroplasty. Evaluation During Hospitalization and Three Months After Discharge*

Comparison of Enoxaparin and Warfarin for the Prevention of Venous Thromboembolic Disease After Total Hip Arthroplasty. Evaluation During Hospitalization and Three Months After Discharge*

An Improved Definition of Immune Heparin-Induced Thrombocytopenia in Postoperative Orthopedic Patients

Systemic effects induced by intralesional injection of ω-conotoxin MVIIC after spinal cord injury in rats

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