Extreme red shifted SERS nanotags

Bedics, Matthew A.; Kearns, Hayleigh; Cox, Jordan M.; Mabbott, Samuel; Ali, Fatima; Shand, Neil C.; Faulds, Karen; Benedict, Jason B.; Graham, Duncan; Detty, Michael R.

doi:10.1039/c4sc03917c

Cited by 51 publications

(79 citation statements)

References 43 publications

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“…[6][7][8][9] To exploit this, there is a great need to design SERS nanotags, which give reproducible response, can provide strong enhancements and, in particular, are optically active in the IR region. Following initial studies, 3,11 HGNs and 100 nm AuNPs were modified with dye 1 and their ability as 1550 nm SERS nanotags investigated. Figure S1, ESI, shows that the 100 nm AuNPs make for better SERS substrates with a 4-fold increase in SERS intensity over the HGNs being observed.…”

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confidence: 99%

“…This suggests that the selenophene group adheres more effectively to the gold surface than thiophene and supports previous reports where selenolates have shown a greater affinity for gold surfaces than thiolates and phenyls. 11,26,27 Due to the exceptional SERS response obtained with these nanotags, particle dilution studies were conducted in order to calculate limits of detection (LOD) and further determine the level of sensitivity that can be achieved at this extremely red-shifted laser excitation. The LOD Commercial Nanotag study was conducted over the concentration range 1.7 nM to 80 pM.…”

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confidence: 99%

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Sensitive SERS nanotags for use with 1550 nm (retina-safe) laser excitation

Kearns

Bedics

Shand

et al. 2016

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This version is available at https://strathprints.strath.ac.uk/55414/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output. Raman scattering provides good molecular specificity however, it is dependent on the 4 th power of the excitation frequency, thus scattering is weak when infrared (IR) excitation is used. Sensitive SERS Nanotags for Use with 1550 nm (Retina-Safe) Laser Excitation

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Sensitive SERS nanotags for use with 1550 nm (retina-safe) laser excitation

Kearns

Bedics

Shand

et al. 2016

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“…When Kobat et al compared two excitation wavelengths (775 and 1280 nm) using two photon fluorescence microscopy (TPM) to label and image mouse blood vessels in vivo and ex vivo, the authors found that high contrast images obtained by using 1280 nm excitation had the twice the depth penetration as those obtained at 775 nm [332]. Recently, Bedics et al developed an extreme red-shifted SERS nanotag comprised of chalcogenopyrylium dyes containing phenyl 2-thienyl and 2-selenophenyl substituents (with absorption wavelengths of 1064 nm) on the surface of HGNs (SPR = 720 nm) for use with 1280 nm laser excitation [333]. The limit of detection was found to be in the picomolar range for all 14 dyes used in the study and sensitivity of detection was attributed in part to the enhanced EM field associated with the HGNs.…”

Section: Sers Nanotagsmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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“…The selection of laser excitation wavelength has a significant impact on experimental capabilities, and whilst typically visible excitation is used (e.g. 488, 514.5, 532 and 633 nm), SERS has been reported from the near UV (325 nm), the near IR (785 and 830 nm) as well as recently at even longer wavelengths such as 1064, 1280 and 1550 nm . This selection process is often determined by a need to compromise between minimising sample fluorescence and maximising scattering efficiencies (especially if resonance is also used).…”

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Achieving optimal SERS through enhanced experimental design

Fisk

Westley

Turner

et al. 2015

J Raman Spectroscopy

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One of the current limitations surrounding surface‐enhanced Raman scattering (SERS) is the perceived lack of reproducibility. SERS is indeed challenging, and for analyte detection, it is vital that the analyte interacts with the metal surface. However, as this is analyte dependent, there is not a single set of SERS conditions that are universal. This means that experimental optimisation for optimum SERS response is vital. Most researchers optimise one factor at a time, where a single parameter is altered first before going onto optimise the next. This is a very inefficient way of searching the experimental landscape. In this review, we explore the use of more powerful multivariate approaches to SERS experimental optimisation based on design of experiments and evolutionary computational methods. We particularly focus on colloidal‐based SERS rather than thin film preparations as a result of their popularity. © 2015 The Authors. Journal of Raman Spectroscopy published by John Wiley & Sons, Ltd.

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Extreme red shifted SERS nanotags

Abstract: Extreme red-shifted nanotags have been developed and they provide effective SERS with picomolar detection limits when excited at 1280 nm.

Cited by 51 publications

References 43 publications

Sensitive SERS nanotags for use with 1550 nm (retina-safe) laser excitation

Sensitive SERS nanotags for use with 1550 nm (retina-safe) laser excitation

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Achieving optimal SERS through enhanced experimental design

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