Extreme Deformation of Capsules and Bubbles Flowing through a Localised Constriction

Dawson, Geoffrey; Häner, Edgar; Juel, Anne

doi:10.1016/j.piutam.2015.03.004

Cited by 17 publications

(15 citation statements)

References 26 publications

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“…The model was validated with a capsule squeezing through a rectangular slit. The deformation profile agreed well with the experimental work in [64]. Cells with different elasticity(membrane compressibility modulus) were squeezed through the micropore.…”

Section: Discussionsupporting

confidence: 85%

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Numerical simulation of cell squeezing through a micropore by the immersed boundary method

Tan

Sohrabi

et al. 2017

Proceedings of the Institution of Mechanical Engineers, Part C:

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The deformability of cells has been used as a biomarker to detect circulating tumor cells (CTCs) from patient blood sample using microfluidic devices with microscale pores. Successful separations of CTCs from a blood sample requires careful design of the micropore size and applied pressure. This paper presented a parametric study of cell squeezing through micropores with different size and pressure. Different membrane compressibility modulus was used to characterize the deformability of varying cancer cells. Nucleus effect was also considered. It shows that the cell translocation time though the micropore increases with cell membrane compressibility modulus and nucleus stiffness. Particularly, it increases exponentially as the micropore diameter or pressure decreases. The simulation results such as the cell squeezing shape and translocation time agree well with experimental observations. The simulation results suggest that special care should be taken in applying Laplace-Young equation (LYE) to microfluidic design due to the nonuniform stress distribution and membrane bending resistance.

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Section: Discussionsupporting

confidence: 85%

“…The geometrical information was selected based on the experiments from Ref. [64]. The capsule membrane mechanics was described in Sec.2.2 with a shear modulus of 9 × 10 −2 μN/m .…”

Section: Numerical Resultsmentioning

confidence: 99%

Numerical simulation of cell squeezing through a micropore by the immersed boundary method

Tan

Sohrabi

et al. 2017

Proceedings of the Institution of Mechanical Engineers, Part C:

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“…Straight Droplet breakup [30] Tapered/ conical Droplet breakup [27] Sinusoidal/ cosine Oil trapping, droplet breakup [31] Double-bend Provides deformation and rotation [25] Saw-tooth-shaped Directional transportation by periodic half-open capillary channels [32] Hyperbolic channel Capsule dynamics, encapsulate droplet [33] Shark teeth Provides rapid deformation [34] Within constrictions, the number of possible arrangements is high, and Table 3 summarizes the main types of constrictions that are frequently reported in the literature. Table 3.…”

Section: Constriction Geometry Design Purpose Referencesmentioning

confidence: 99%

Review on Microbubbles and Microdroplets Flowing through Microfluidic Geometrical Elements

et al. 2020

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Two-phase flows are found in several industrial systems/applications, including boilers and condensers, which are used in power generation or refrigeration, steam generators, oil/gas extraction wells and refineries, flame stabilizers, safety valves, among many others. The structure of these flows is complex, and it is largely governed by the extent of interphase interactions. In the last two decades, due to a large development of microfabrication technologies, many microstructured devices involving several elements (constrictions, contractions, expansions, obstacles, or T-junctions) have been designed and manufactured. The pursuit for innovation in two-phase flows in these elements require an understanding and control of the behaviour of bubble/droplet flow. The need to systematize the most relevant studies that involve these issues constitutes the motivation for this review. In the present work, literature addressing gas-liquid and liquid-liquid flows, with Newtonian and non-Newtonian fluids, and covering theoretical, experimental, and numerical approaches, is reviewed. Particular focus is given to the deformation, coalescence, and breakup mechanisms when bubbles and droplets pass through the aforementioned microfluidic elements.Micromachines 2020, 11, 201 2 of 22 droplets through a sudden/gradual expansion/contraction, several numerical and experimental works considered the flow through horizontal pipes, but they are mainly focused on pressure drop [6][7][8][9].The heat and mass transfer can be significantly enhanced in a microsystem due to the high surface volume ratio. Currently, bubble/droplet-based microfluidics has been successfully applied in chemical and biological analysis [10,11], the synthesis of advanced materials [12], sample pretreatment [13], and the encapsulation of cells [14]. Droplets are liquid entities that flow in a immiscible liquid continuous phase, and bubbles are gas entities also flowing in a liquid fluid. The use of droplets as microreactors presents a lot of advantages when compared with single-phase microfluidics, such as: confinement of reactants or prevention of longitudinal dispersion, and cross contamination between samples [15]. The reduction of unwanted adhesion/absorption of the material confined in droplets at the microchannel walls, the possibility of varying, in each droplet the physicochemical conditions under which chemical or biological process develop, and the facilitated heat/mass transport due to the fast mixing promoted by droplets are other benefits [15,16]. The use of bubbles might be interesting to produce contrast agents in medical applications [17], as a source of reactants in the gas phase to promote reactions in liquid or solid (i.e., microchannel wall) phases [18], and to study in vitro gas embolisms [19].Microfluidic devices (length scales lower than one millimeter) comprise microfluidic elements, analogous to their macroscale counterparts, to transport and distribute fluids, to promote mixing, reaction, and mass transfer. In the case of multiphase flows, ...

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“…In the literature, there are several experimental studies such as those by Leclerc et al (2012), Risso et al (2006), Dawson et al (2015), Lee and Fung (1969) and Vitkova et al (2004), addressing the deformation of synthetic microcapsules in constrictions. It was experimentally observed that capsules tend to increase their axial length and decrease their radial width as capillary number increases.…”

Section: Introductionmentioning

confidence: 99%

A practical approach for extracting mechanical properties of microcapsules using a hybrid numerical model

Rahmat

Meng

Emerson

et al. 2020

Microfluid Nanofluid

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In this paper, the deformation of compliant microcapsules is studied in narrow constrictions using a hybrid particle-based model. The model combines the Smoothed Particle Hydrodynamic (SPH) method for modelling fluid flow and the Mass Spring Model (MSM) for simulating deformable membranes. The model is initially validated for the dynamics of microcapsules in shear flow. Then, several quantitative parameters such as the deformation index, frontal tip and rear tail curvatures and the passage time are introduced and their variations are studied with respect to capillary number and constriction size. Subsequently, a dependency analysis is performed on these quantitative parameters and some recommendations are made on fabrication of microfluidic devices and analysis of microcapsules for extracting their mechanical properties. It is revealed that the deformation index and frontal tip and rear tail curvatures are the most suitable parameters for correlating the elastic properties to the dynamics of microcapsules.

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Extreme Deformation of Capsules and Bubbles Flowing through a Localised Constriction

Cited by 17 publications

References 26 publications

Numerical simulation of cell squeezing through a micropore by the immersed boundary method

Numerical simulation of cell squeezing through a micropore by the immersed boundary method

Review on Microbubbles and Microdroplets Flowing through Microfluidic Geometrical Elements

A practical approach for extracting mechanical properties of microcapsules using a hybrid numerical model

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