Extraversion and neuroticism in rats

Garcia-Sevilla, L.

doi:10.1016/0191-8869(84)90026-6

Cited by 77 publications

(18 citation statements)

References 49 publications

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“…Ndufs4 GT/GT mice showed a similar coping strategy in the TST too. Furthermore, we found that Ndufs4 GT/GT mice presented with increased emotionality following CUS as indicated by the increased defecation in the open field [63][64][65] Depression has frequently been associated with decreased neurogenesis 39 . In support of this, we also found reduced neurogenesis in WT mice exposed to CUS.…”

Section: Discussionmentioning

confidence: 83%

Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice

et al. 2020

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Mitochondria play a critical role in bioenergetics, enabling stress adaptation, and therefore, are central in biological stress responses and stress-related complex psychopathologies. To investigate the effect of mitochondrial dysfunction on the stress response and the impact on various biological domains linked to the pathobiology of depression, a novel mouse model was created. These mice harbor a gene trap in the first intron of the Ndufs4 gene (Ndufs4 GT/GT mice), encoding the NDUFS4 protein, a structural component of complex I (CI), the first enzyme of the mitochondrial electron transport chain. We performed a comprehensive behavioral screening with a broad range of behavioral, physiological, and endocrine markers, high-resolution ex vivo brain imaging, brain immunohistochemistry, and multiplatform targeted mass spectrometry-based metabolomics. Ndufs4 GT/GT mice presented with a 25% reduction of CI activity in the hippocampus, resulting in a relatively mild phenotype of reduced body weight, increased physical activity, decreased neurogenesis and neuroinflammation compared to WT littermates. Brain metabolite profiling revealed characteristic biosignatures discriminating Ndufs4 GT/GT from WT mice. Specifically, we observed a reversed TCA cycle flux and rewiring of amino acid metabolism in the prefrontal cortex. Next, exposing mice to chronic variable stress (a model for depression-like behavior), we found that Ndufs4 GT/GT mice showed altered stress response and coping strategies with a robust stress-associated reprogramming of amino acid metabolism. Our data suggest that impaired mitochondrial CI function is a candidate driver for altered stress reactivity and stress-induced brain metabolic reprogramming. These changes result in unique phenomic and metabolomic signatures distinguishing groups based on their mitochondrial genotype.

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Section: Discussionmentioning

confidence: 83%

Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice

et al. 2020

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“…Defecation, another individual pattern that showed differences among groups, presented an inverted "Ushaped" relationship. Different authors postulate the existence of an inverse relationship between emotional reactivity and exploratory behavior [Broadhurst, 1960;Archer, 1973], even though other authors found nonsignificant relations [Garcia-Sevilla, 1984]. Garcia-Sevilla [1984] found orthogonality between ambulation and defecation (index of emotionality) in a low frightening open field.…”

Section: Discussionmentioning

confidence: 99%

Age effects on the social interaction test in early adulthood male rats

Garau

Sala

et al. 2000

Depress. Anxiety

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The effects of age on active and passive social interaction were studied in Wistar rats using the social interaction test (S.I.T.). Individual behaviors such as ambulation, rearing, and defecation were also studied. Despite the widespread use of the S.I.T. in anxiety research, the effects of age on the S.I.T have not been studied thoroughly. Male Wistar rats of 75, 135, and 180 days old were used. Our results showed age effects on active social contact, passive social contact, ambulation, rearing, and defecation. At 135 days old, animals presented the lowest scores on active social behavior and the highest scores on defecation. Moreover, exploratory behavior measured by ambulation and rearing decreased with age. These results suggest that age could be a relevant variable in the social interaction test. Depression and Anxiety 12:226–231, 2000. © 2000 Wiley‐Liss, Inc.

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“…Many studies of nonhuman primates and other species (e.g., rats [Garcia-Sevilla, 1984], guppies [Budeav, 1997], cats [Gosling, 1999;Saxton et al, 1987], octopuses [Mather & Anderson, 1993], hyenas and dogs [Gosling, 1999], and nonhuman primates [Bard & Gardner, 1996;Bolig et al, 1992;Capitanio, 1999;Chamove et al, 1972;Dutton et al, 1997;Gold & Maple, 1994;King & Figueredo, 1997;Laudenslager et al, 1999;McGuire et al, 1994;Mondragon-Ceballos et al, 1991;Mondragon-Ceballos & Santillan-Doherty, 1994;Murray, 1996;Stevenson-Hinde et al, 1980a;van Hooff, 1970]) have found some evidence of factors that appear similar to some or all of the three Big Five Factors selected for this study. In humans, these three factors have shown cross-cultural stability and heritability [McCrae & Costa, 1997;Rowe, 1994;Steen, 1996].…”

Section: Methodsmentioning

confidence: 99%

Personality traits in captive lion-tailed macaques (Macaca silenus)

Rouff¹,

Sussman²,

Strube³

2005

Am. J. Primatol.

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Personality influences an individual's perception of a situation and orchestrates behavioral responses. It is an important factor in elucidating variation in behavior both within and between species. The major focus of this research was to test a method that differs from those used in most previous personality studies, while investigating the personality traits of 52 captive lion-tailed macaques from four zoos. In this study, data from behavioral observations, a P-type principal components analysis (PCA), and bootstrapped confidence intervals as criteria for judging the significance of factor loadings were used rather than subjective ratings, R-type factor analyses, and arbitrary rules of thumb to determine significance. We investigated the relationships among individual component scores and sex, hormonal status, and dominance rank (controlling for age and social group) using a multiple regression analysis with bootstrapped confidence intervals. Three personality dimensions emerged from this analysis: Component 1 contained Extraversion-like behaviors related to sociability and affiliativeness. The higher mean Component score for females suggests that they are more "extraverted" than males. Only agonistic behaviors were significantly related to component 2. High-ranking individuals exhibited higher mean Component 2 scores than mid- or low-ranked individuals. Bold and cautious behaviors both loaded positively on Component 3, suggesting a dimension related to curiosity. The mean Component 3 score for females was higher than the mean score for males. The method used in this study should facilitate intraspecific and general interspecific comparisons. Developing a standardized trait term list that is applicable to many species, and collecting trait term data in the same manner and concurrent with behavioral observations (and physiologic measures when feasible) could prove useful in primate research and should be explored.

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Extraversion and neuroticism in rats

Cited by 77 publications

References 49 publications

Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice

Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice

Age effects on the social interaction test in early adulthood male rats

Personality traits in captive lion-tailed macaques (Macaca silenus)

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