Extrathymic T-lymphocyte development

Blais, Marie-Ève; Louis, Isabelle; Corneau, Sophie; Gérard, Gwladys; Terra, Rafik; Perreault, Claude

doi:10.1016/s0301-472x(03)00026-2

Cited by 14 publications

(13 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, we have shown that despite the absence of detectable CLP, B, and NK cells, HSCs along with T-and NKT-lineage cells developed from Pbx1 Ϫ/Ϫ ES cells in Rag1-deficient mice. This supports the existence of alternative pathways for T-cell generation, including extrathymic pathways, 44,45 or pathways independent of CLPs. 34 We cannot rule out the possibility that T cells arose during fetal development and persisted postnatally; however, the presence of T cells in mice receiving transplants of Pbx1 Ϫ/Ϫ bone marrow cells is most consistent with de novo T-cell production independent of CLPs.…”

Section: Discussionsupporting

confidence: 68%

B-cell development fails in the absence of the Pbx1 proto-oncogene

Sanyal¹,

Tung

Karsunky³

et al. 2007

Blood

View full text Add to dashboard Cite

Pbx1, a homeodomain transcription factor that was originally identified as the product of a proto-oncogene in acute pre-B-cell leukemia, is a global regulator of embryonic development. However, embryonic lethality in its absence has prevented an assessment of its role in B-cell development. Here, using Rag1-deficient blastocyst complementation assays, we demonstrate that Pbx1 null embryonic stem (

show abstract

Section: Discussionsupporting

confidence: 68%

B-cell development fails in the absence of the Pbx1 proto-oncogene

Sanyal¹,

Tung

Karsunky³

et al. 2007

Blood

View full text Add to dashboard Cite

show abstract

“…Repeated viral infections select for T cells with broad crossreactivity but can result in drop-out of some CD8 clones (9). Thymus-independent T cells exist, especially in the gut, but they cannot compensate for loss of the thymus due to skewed TCR diversity and limited recirculatory capacity (10). These processes steadily impoverish T-cell diversity, reducing responses to novel infections or immunizations.…”

Section: ␣␤ T Cells: the Costs And Rewards Of A Thymic Educationmentioning

confidence: 99%

Cell-mediated Adaptive Immune Defense of the Lungs

Curtis¹

2005

Proceedings of the American Thoracic Society

View full text Add to dashboard Cite

The adaptive immune system protects the lungs against an astounding range of pathogens, whether invading our alveoli or hiding within our own cells, and it does so with increased efficiency each time we encounter the same or related organisms. These properties-versatility, exquisite specificity, and memory-contribute to defense against all classes of pulmonary pathogens. Adaptive responses are essential for intracellular pathogens, notably mycobacteria, whose clearance requires classical macrophage activation; for viruses, which have evolved many ways to evade or neutralize innate immunity; and for fungi, which combine the explosive growth potential of bacteria with the sophistication of a eukaryotic genome.The attributes of versatility, specificity, and memory depend on a complex interplay of many cell types and multiple soluble

show abstract

“…It is very efficient in repopulating the peripheral compartment due, probably, to multiple stimulation in their initial niche. Finally, like oncostatin transgenic mice (40,41), SC12 pre-T cells provide an excellent tool for the study of early T cell lineage commitment in the periphery, independently from thymic influence.…”

Section: Cd44mentioning

confidence: 99%

Extrathymic Hemopoietic Progenitors Committed to T Cell Differentiation in the Adult Mouse

Arcangeli

Lancrin

Lambolez

et al. 2005

The Journal of Immunology

View full text Add to dashboard Cite

The role of the thymus in T cell commitment of hemopoietic precursor is yet controversial. We previously identified a major T cell progenitor activity in precursor cells isolated from bone marrow-derived spleen colonies. In this study, we characterize the properties of these pre-T cells. We demonstrate that they have unique phenotype and can be generated in a total absence of any thymic influence. Indeed, even when studied at the single-cell level, extrathymic T cell-committed precursors express T cell-specific genes. Moreover, these cells are not committed to a particular T cell differentiation pathway because they can generate both extrathymic CD8αα+ intraepithelial lymphocytes and thymus-derived conventional thymocytes. We also compared these pre-T cells with fully T cell-committed thymic progenitors. When tested in vitro or by direct intrathymic transfer, these cells have a low clonogenic activity. However, after i.v. transfer, thymus repopulation is efficient and these precursors generate very high numbers of peripheral T cells. These results suggest the existence of extra steps of pre-T cell maturation that improve thymus reconstitution capacity and that can be delivered even after full T cell commitment. Consequently, our studies identify a source of extrathymic progenitors that will be helpful in defining the role of the thymus in the earliest steps of T cell differentiation.

show abstract

Extrathymic T-lymphocyte development

Cited by 14 publications

References 70 publications

B-cell development fails in the absence of the Pbx1 proto-oncogene

B-cell development fails in the absence of the Pbx1 proto-oncogene

Cell-mediated Adaptive Immune Defense of the Lungs

Extrathymic Hemopoietic Progenitors Committed to T Cell Differentiation in the Adult Mouse

Contact Info

Product

Resources

About