Extrathoracic Mesothelial Proliferations and Their Mimics

Lloreta‐Trull, Josep

doi:10.1080/01913120500313200

Cited by 8 publications

(7 citation statements)

References 75 publications

(89 reference statements)

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“…However, the wide morphologic diversity is a well-recognized feature [25]. The most commonly cited differential diagnosis include carcinoma of the rete testis, ovarian epithelial-type tumours of testis and paratestis, secondary adenocarcinomas, adenomatoid tumour and pleomorphic sarcomas [22,24,26,27]. In our case, the pre-operative biopsy specimen lacked common features of mesothelioma, while the sex cord-like appearance (i.e.…”

Section: Discussionmentioning

confidence: 80%

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature

et al. 2020

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Background: Malignant mesothelioma of the tunica vaginalis is a rare tumour which comprises less than 1% of all mesotheliomas. Case presentation: 69-years old patient with painful hard mass and hydrocele in the right scrotum to whom a right hydrocelectomy was performed. Any history of scrotal trauma or exposure to asbestos was not present. Excisional biopsy revealed a multinodular tumour with focal areas of necrosis and infiltrative growth. According to morphological and immunohistochemical findings, diagnosis of malignant biphasic mesothelioma of the tunica vaginalis testis was made. Two months after hydrocelectomy, right inguinal orchidectomy was performed. Postsurgical whole body CT scan revealed paraaortic and pararenal lymphadenopathy, likely to be metastatic. Adjuvant treatment with 6 cycles of cisplatin and pemetrexed was applied. After 3 cycles of chemotherapy, CT scan showed progression and the treatment was changed to gemcitabine 1 month after. Conclusions: Although malignant mesothelioma of the tunica vaginalis is a rare malignancy, it poses a diagnostic challenge which can mimic common inguinal or scrotal diseases such as hydrocele. Despite aggressive surgical procedures or adjuvant therapies, the prognosis remains poor.

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Section: Discussionmentioning

confidence: 80%

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature

et al. 2020

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“…A firm painless scrotal mass [194], numerous small papillary lesions or multiple nodules studded on the internal surface of the hydrocele sac, diffuse thickening of the tunica vaginalis [195], and a solid coat around the tunica vaginalis with variable features.…”

Section: Discussionmentioning

confidence: 99%

“…Cellular nuclear pleomorphism and papillary configuration are signs of lethal potential [52]. An infiltrative pattern of growth with increased cellularity nuclear pleomorphism and high mitotic rate and stromal invasion [105, 195]. Large lymphoid cells with clear or slightly eosinophilic cytoplasm with large strongly atypical polymorphic nuclei and a great number of mitoses; epithelioid features with papillary growth, papillary tubules, and solid growth in invasive foci [196].…”

Section: Discussionmentioning

confidence: 99%

Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register

et al. 2019

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Background Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is a rare disease with a poor prognosis. The diagnosis and management of these lesions are often difficult for pathologists, surgeons, oncologists and occupational physicians. A preoperative diagnosis of malignancy is rarely made, and there is no established effective therapy except orchidectomy. Methods A systematic literature review was conducted among the articles published in the English literature on primary MMTVT. Moreover four cases from the Apulia mesothelioma register are reported here. Results Two hundred eighty-nine cases of MMTVT have been reported from 1943 to 2018. Overall asbestos exposure has been investigated only for 58% of all cases reported in this review, while in 41.8% this data are not available. Noteworthy is the fact that in many reports there is not an anamnestic reconstruction of any asbestos exposure. A history of direct occupational, environmental or familial asbestos exposure is found in 27.6% of the cases. The four cases from the Apulia mesothelioma register are all with ascertained occupational exposure to asbestos. Conclusions The true incidence of asbestos exposure in MMTVT is underestimated because of insufficient information reported in older literature. To establish a broad consensus on the causal relationship between asbestos and MMTVT in the scientific community its necessary to analyze the same variables in the epidemiological studies. In general it should be recommended that a positive history of exposure to asbestos or to asbestos–containing materials are at risk for the development of a MMTVT and should be monitored.

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“…Moreover, even though electron microscopy (transmission electron microscopy—TEM) is an ancillary technique mainly used in the field of scientific research [ 18 ], it may continue to have a purpose in the pathological diagnosis of difficult cases, as also reported in the latest statement for the pathological diagnosis of mesothelioma [ 19 ]. In fact, with ultrastructural examination, it is possible to identify cellular details that reveal the mesothelial origin, such as elongated and branching microvilli as well as giant desmosomes and evident intracytoplasmic tonofilaments [ 20 , 21 , 22 , 23 , 24 ]. Scanning electron microscopy (SEM) equipped with an X-ray microanalysis system (EDS) on pathological specimens may also be considered as an additional tool for the research of fibers or crystals eventually attributable to a previous exposure history.…”

Section: Introductionmentioning

confidence: 99%

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

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Primary ovarian mesothelioma is a rare, aggressive neoplastic disease with a poor prognosis. At onset, the tumor is only rarely limited to the ovaries and usually already widespread in the peritoneum. The rarity of this entity and the difficulties differentiating it from either ovarian carcinoma or peritoneal mesothelioma may lead to frequent misdiagnoses and may raise some concerns about its histogenesis. Thus, reporting such rare cases is fundamental to gain greater awareness of this neoplasm and try to answer unsolved questions. Herein, we described four cases of histological diagnoses of ovarian mesothelioma extrapolated by the regional mesothelioma register of Apulia (southern Italy). In all cases, a detailed medical history was collected according to national mesothelioma register guidelines. A broad panel of antibodies was used for immunohistochemistry to confirm the diagnoses. Moreover, ovarian tissue samples were also examined by transmission and scanning electron microscopy, detecting asbestos fibers and talc crystals in two cases. Because of the few cases described, we reviewed the English literature in the Medline database, focusing on articles about ovarian mesothelioma “misclassification”, “misdiagnosis”, “diagnostic challenge” or “diagnostic pitfall” and on unsolved questions about its histogenesis and possible risk factors.

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Extrathoracic Mesothelial Proliferations and Their Mimics

Cited by 8 publications

References 75 publications

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature

Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

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