Extraterritorial osteoclast traits of primary cancer cells

Schramm, Henning M.

doi:10.5430/jst.v1n2p65

Cited by 5 publications

(4 citation statements)

References 100 publications

(95 reference statements)

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“…While optimization methods based on evolutionary algorithms offer great potential, it is worth noting that for shape optimization processes involving small changes in the final geometry, simpler methods can often sufficient and even prove to be more robust than other optimization approaches. A noteworthy conclusion supporting this viewpoint is presented in the work by Matthias Schramm et al [42]. In their study, the researchers highlight that in scenarios where the modifications to the geometry are relatively minor, gradient-based optimization using the method of steepest descent can yield satisfactory results.…”

Section: Shape Optimization Approachmentioning

confidence: 73%

Structural and Shape Optimization in Aerodynamic Airfoil Performance: A Literature Review

Juvinel,

Pinto Roa,

Schaerer

2023

Preprint

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An airfoil is the geometric shape of a cross-section of a wing. When it is exposed to the flow of a fluid over its surface, it generates both lift and drag forces through a pressure distribution. Designing an efficient airfoil for aerodynamic applications is a complex challenge in the field of aerodynamic engineering, with the aim of achieving an optimal lift-to-drag ratio. The success of airfoil design hinges on the effective reduction of drag force under specific conditions, while simultaneously attaining the desired lift without encountering significant flow separation, such as boundary layer shedding. Furthermore, the design must adhere to lifting force limitations and meet structural requirements. In the field of airfoil design and optimization, literature review articles provide a valuable resource by offering an overview of the latest advancements in specific areas. These areas encompass a wide range of topics including the design and testing of adaptive geometry wings, such as morphing wing technology as well as the application of shape optimization techniques to enhance airfoil performance. Our goal is to provide researchers with an in-depth review of relevant articles published to date, examining the applied approaches utilized to tackle the complex problem of airfoil design and explore the methodology employed to address it, from a broad perspective on the topic.

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Section: Shape Optimization Approachmentioning

confidence: 73%

Structural and Shape Optimization in Aerodynamic Airfoil Performance: A Literature Review

Juvinel,

Pinto Roa,

Schaerer

2023

Preprint

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“…low-oxygen conditions) inducible properties (HIF1, HIF2) [32] , coupled with mesenchymal cells (e.g. the CxCL12-CXCR4 axis) [49] ; sensitivity to antirheumatics; constitutive activation of NFkappaB, the Wnt/beta-catenin cell signalling pathway, the shared cytokine and chemokine signalling pathways, and the COX-2/PGE2 pathway [50] ; finally some overlapping extraterritorial osteoclast traits of primary cancer cells [51] .…”

Section: Discussionmentioning

confidence: 99%

MiR-140 in cancer and beyond: a brief update

Zhang

2012

JST

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Cancer chemotherapy causes many side-effects, including joint pain. We speculate that a better understanding of the common biology of cancer and osteoarthritis could help us to find out ways to cure the cancer and to alleviate pain if their shared mechanisms are responsible for joint pain and/or related side-effects. In this mini-vision and reflection, we focus on the networks of miR-140 that are involved in both cancer and osteoarthritis during development and carcinogenesis. Frontiers including autophagy, potential stem-cell therapy and early nanotechnological diagnosis of those diseases will be briefly discussed.

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“…When several preosteoclasts fuse into an osteoclast they intracellularly overexpress certain signaling pathways which are likewise overexpressed in cancer cells during their proliferation 64. STAT3 and NFkappaB are a prerequisite for the maturation of preosteoclasts into osteoclasts, and consequently the inhibition of NFkappa B activity blocks this developmental differentiation.…”

Section: Part 2: the Seemingly Inflammatory Process Of Emyet Is Supermentioning

confidence: 99%

The Epithelial-Myeloid-Transition (EMyeT) of cancer cells as a wrongly perceived primary inflammatory process eventually progressing to a bone remodeling malignancy: the alternative pathway for Epithelial- Mesenchymal-Transition hypothesis (EMT)?

Schramm¹

2019

J. Cancer

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Cancer cells express multiple markers expressed by mesenchymal as well as myeloid cells in common and in addition specific markers of the myeloid lineages, especially those of dendritic cells, macrophages and preosteoclasts. It has also been possible to identify monocyte-macrophage gene clusters in cancer cell specimens as well as in cancer cell lines. Accordingly, like myeloid cells cancer cells often express pro-inflammatory cytokines, and consequently the carcinoma may be perceived by the organism as a primary inflammatory process comparable to the immune inflammatory reactions in the eye or in the case of arthritis. This would explain why a carcinoma may induce a certain alarm state in the organism by increasing a fatal sympathetic tone in the patient, supplying the carcinomas with nutrients at the cost of other requirements, inducing tolerance against the cancer cells mistaken as myeloid cells, provoking fibrosis and neoangiogenesis, and increasing inflammatory cells at the carcinoma site. This seemingly inflammatory process of Epithelial-Myeloid-Transition (EMyeT) is superimposed by the progression of part of the myeloid cancer cells to stages comparable to preosteoclasts and osteoclasts, and their development to metastasizing carcinomas often at the site of bone. This concept of carcinogenesis and malignant progression described here challenges the widely accepted EMT-hypotheses and could deliver the rationale for the various peculiar aspects of cancer and the variety of therapeutic antitumoral measures.

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Extraterritorial osteoclast traits of primary cancer cells

Cited by 5 publications

References 100 publications

Structural and Shape Optimization in Aerodynamic Airfoil Performance: A Literature Review

Structural and Shape Optimization in Aerodynamic Airfoil Performance: A Literature Review

MiR-140 in cancer and beyond: a brief update

The Epithelial-Myeloid-Transition (EMyeT) of cancer cells as a wrongly perceived primary inflammatory process eventually progressing to a bone remodeling malignancy: the alternative pathway for Epithelial- Mesenchymal-Transition hypothesis (EMT)?

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