Extraskeletal osteogenic sarcoma arising in irradiated tissue

Auerbach, Oscar; Friedman, Milton; Weiss, Leo; Amory, Harold I.

doi:10.1002/1097-0142(195109)4:5<1095::aid-cncr2820040528>3.0.co;2-n

Cited by 40 publications

(6 citation statements)

References 6 publications

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“…Although potential side effects of radiation should be taken into consideration, especially with young patients, the choice of radiation therapy in the present case was considered to be reasonable after removal of the tumour because of the huge mass of the IP (13×6 cm). However, the possibility exists that in the present case the "IP" could have been a very early stage of myositis ossificans, since several cases of osteosarcoma arising in myositis ossificans have been reported [1,9].…”

Section: Discussionmentioning

confidence: 75%

Double malignant neoplasms occurring long after local radiation to the oral mucosa

1998

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A 59-year-old woman who had received cobalt-60 (60Co) interstitial radiation therapy (total 44 Gy) in the right bucco-gingival region for inflammatory pseudotumour was found to have metachronous double malignant neoplasms. Initial osteosarcoma of the right mandibular angle and subsequent squamous cell carcinoma of the right buccal mucosa were identified 28 and 33 years after the radiation, respectively. Since both tumours were located very close to the focus of previous radiation, the therapy was considered to be responsible for their genesis. The patient had systemic metastases of the osteosarcoma.

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Section: Discussionmentioning

confidence: 75%

Double malignant neoplasms occurring long after local radiation to the oral mucosa

1998

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“…Allan and Soule reported a history of trauma in eight of their 26 cases [1]. ESOSs have been reported to have occurred in previously irradiated areas [2,3]. Lidang et al also reported that two patients with superficial ESOSs previously received radiation in the same area [13].…”

Section: Discussionmentioning

confidence: 99%

Extraskeletal osteosarcoma arising in the buttock

Oonuma

Hatori

Hosaka

et al. 2001

Upsala Journal of Medical Sciences

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Extraskeletal osteosarcoma is a rare sarcoma that accounts for about 1 % of malignant soft tissue tumours. We report an very unusual case of a small-size extraskeletal osteosarcoma arising in the superficial subcutaneous region of the buttock. The patient was a 55 year-old female. She incidentally noticed a small nodule in the right trochanteric region. It was removed under local anesthesia at a private clinic. An additional wide excision was performed at our hospital. There was an 8 mm? 10 mm mass in the subcutaneous tissue. No invasion of the underlying fascia was observed. Microscopic examination of the removed tumour showed bizarre-looking spindle and giant cells with lace-like osteoid. The tumour was diagnosed as extraskeletal osteosarcoma. Chemotherapy with Rosen T-20 was administered to the patient. The patient has survived without recurrence or metastasis for 4 years since the primary surgery. Its superficial location, very small size, wide excision, and chemotherapy were thought to contribute to her long survival.

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“…In addition to the aformentioned radiation‐induced cancers, and earlier reported cases, some of the cancers induced by incidental or therapeutic radiation reported were: leukemia; bone sarcoma; thyroid carcinoma in children and adults; extraskeletal osteogenic sarcoma; and fibrosarcoma of the soft tissues . It is perhaps important to note that whereas leukemias, thyroid cancer, and sarcomas were the most commonly observed radiation‐induced cancers, only a few lymphosarcomas were encountered.…”

Section: Introductionmentioning

confidence: 91%

A note from history: Landmarks in history of cancer, Part 6

Hajdu

Vadmal

2013

Cancer

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In the 3 decades from 1940 to 1970, the United States became the nucleus for research, diagnosis, and treatment of cancer. The discovery of anticancer drugs, and the clinical demonstration that chemotherapy and radiation can cure cancer and have the ability to prevent recurrence of cancer, were incontrovertibly the most remarkable groundbreaking events. Consequently, the trend of less surgery and more multimodality therapy began. The introduction of radioautography, mammography, ultrasonography, computed tomography, Papanicolaou smear, and other novel laboratory tests furthered early detection of cancer and refined accurate diagnosis. The unequivocal linking of lung cancer to cigarette smoking made medical history. The delineation of the potential role of oncogenes adduced new thoughts about oncogenesis and cancer prevention, and pathologists finalized the classification and nosology of tumors. Finally, it is worth noting that although more advances were made in the detection, diagnosis, and treatment of cancers than any other period in history, the overall mortality rate of patients with cancer remained high and unchanged. Cancer 2013;119:4058-82.V C 2013 American Cancer Society.KEYWORDS: history of cancer, history of medical oncology, history of surgical oncology, history of radiation therapy, history of diagnostic radiology, history of surgical pathology, history of cytopathology, history of cancer research, history of immunology, history of cancer epidemiology and cancer institutions.

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Extraskeletal osteogenic sarcoma arising in irradiated tissue

Cited by 40 publications

References 6 publications

Double malignant neoplasms occurring long after local radiation to the oral mucosa

Double malignant neoplasms occurring long after local radiation to the oral mucosa

Extraskeletal osteosarcoma arising in the buttock

A note from history: Landmarks in history of cancer, Part 6

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