Extraskeletal mesenchymal chondrosarcoma arising in adductor magnus with metastatic foci

Abstract

Mesenchymal chondrosarcoma is a rare and aggressive chondrogenic neoplasm arising from the bone or the soft tissue. Mesenchymal chondrosarcomas develop outside the osseous structures in about one-third of cases, and the majority of these occur in the meninges and the brain parenchyma. Intramuscular extraskeletal mesenchymal chondrosarcoma (EMC) is exceedingly rare, with very few cases reported in the literature. Although mesenchymal chondrosarcoma has a high potential for metastasis, there have been no reports of pulmonary metastasis from an EMC of intramuscular origin. Here, we describe a patient who came to our facility with a history of progressively worsening left lower extremity pain and swelling, and was found to have pathology-proven EMC originating in the left adductor magnus, with complete workup demonstrating multiple bilateral pulmonary metastases in addition to a possible metastatic focus in the right adrenal gland discovered during the interval surveillance period.

Extraskeletal Mesenchymal Chondrosarcoma, a Rare Entity with Unusual Metastases: A Case Report

“…Post-contrast images show diffuse heterogeneous or nodular enhancement. [4] Diagnosis is based on tumor morphology and various immunohistochemical stains. Histologically, the tumor has a bimorphic morphology composed of undifferentiated round blue cells and hyaline cartilage.…”

“…This is a treatment regimen used typically in cases of Ewing's sarcoma. [4] Metastasis from ESMC has been reported to occur in <20% of patients occurring over a period of 10 months-8 years. [6] Pulmonary, bone, and lymph node metastasis are usually seen at the time of diagnosis.…”

“…Compared to chondrosarcoma, MC are quite aggressive, and have 5 and 10-year survival rates of 54.6% and 27.3%, respectively. [3,4] ESMC commonly involves the orbit, meninges, and lower limbs. Upper limb involvement is rare.…”

“…Compared to chondrosarcoma, MC are quite aggressive, and have 5 and 10-year survival rates of 54.6% and 27.3%, respectively. [ 3 , 4 ]…”

Primary mesenchymal chondrosarcoma of the mediastinum with adrenal metastasis: A rare scenario

“…[ 1 ] Reports of metastasis of MC to unusual sites such as adrenal, pancreas, and thyroid are few in the published literature. [ 2 3 4 5 ] Detection of adrenal metastasis on PET/CT in case of extraskeletal MC is however not reported. Histopathologic evidence of the adrenal metastasis was not achievable as the patient was lost to follow-up; however, the imaging features suggest this possibility given the overall scenario.…”