Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase

Adams, John S.; Hewison, Martin

doi:10.1016/j.abb.2012.02.016

Cited by 231 publications

(203 citation statements)

References 98 publications

(131 reference statements)

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…2 Most patients on dialysis are treated with vitamin D receptor agonists (VDRAs), such as calcitriol, doxercalciferol, or paracalcitol, 3 for management of secondary hyperparathyroidism; however, if the hypothesized pleiotropic effects of vitamin D require local production, supplementation with VDRAs without its nutritional vitamin D precursor may not optimize clinical benefits, particularly as more than half of patients on hemodialysis are deficient in total serum 25-hydroxy vitamin D [25(OH)D]. 4 The 2009 Kidney Disease: Improving Global Outcomes Chronic Kidney DiseaseMineral and Bone Disorder (CKD-MBD) clinical practice guideline suggests supplementing with nutritional vitamin D to achieve 25(OH)D $30 ng/ml in patients on hemodialysis.…”

mentioning

confidence: 99%

“…Local production of 1,25-dihydroxy vitamin D3 [1,25(OH) 2 D] via extrarenal 1-a hydroxylases 1 is postulated to have paracrine and autocrine functions separate from its classic endocrine function on bone. 2 Most patients on dialysis are treated with vitamin D receptor agonists (VDRAs), such as calcitriol, doxercalciferol, or paracalcitol, 3 for management of secondary hyperparathyroidism; however, if the hypothesized pleiotropic effects of vitamin D require local production, supplementation with VDRAs without its nutritional vitamin D precursor may not optimize clinical benefits, particularly as more than half of patients on hemodialysis are deficient in total serum 25-hydroxy vitamin D [25(OH)D].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial

Miskulin

Majchrzak²,

Tighiouart

et al. 2015

JASN

View full text Add to dashboard Cite

Locally produced 1,25-dihydroxyvitamin D3 may have pleiotropic effects outside of bone. Experimental and observational studies suggest that nutritional vitamin D may enhance erythropoiesis in settings of 25-hydroxy vitamin D (25(OH)D) deficiency. We conducted a double-blind, placebo-controlled, randomized clinical trial to assess the effects of supplementation with ergocalciferol on epoetin utilization and other secondary outcomes in patients on hemodialysis with serum 25(OH)D ,30 ng/ml. In all, 276 patients were randomized to 6 months of ergocalciferol or placebo. Mean6SD serum 25(OH)D increased from 16.065.9 ng/ml at baseline to 39.2614.9 ng/ml in the ergocalciferol arm and did not change (16.966.4 ng/ml and 17.567.4 ng/ml, respectively) in the placebo arm. There was no significant change in epoetin dose over 6 months in the ergocalciferol or placebo arms (geometric mean rate 0.98 [95% confidence interval (95% CI), 0.94 to 1.02] versus 0.99 [95% CI, 0.95 to 1.03], respectively) and no difference across arms (P=0.78). No change occurred in serum calcium, phosphorus, intact parathyroid hormone, or C-reactive protein levels, cinacalcet use, or phosphate binder or calcitriol dose in either study arm. Rates of all-cause, cardiovascular, and infection-related hospitalizations did not differ by study arm, although statistical power was limited for these outcomes. In conclusion, 6 months of supplementation with ergocalciferol increased serum 25(OH)D levels in patients on hemodialysis with vitamin D insufficiency or deficiency, but had no effect on epoetin utilization or secondary biochemical and clinical outcomes.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial

Miskulin

Majchrzak²,

Tighiouart

et al. 2015

JASN

View full text Add to dashboard Cite

show abstract

“…This concept, extensively reviewed,3, 5, 12, 13, 14, 15, 16, 17, 18 arose from studies of GM‐CSF‐driven differentiation of human blood CD14 + monocytes into motile cells with dendrites (moDC), capable of presenting antigen on MHC class II (MHCII) 19. The properties of these in‐vitro ‐generated moDC were substantially altered when 1,25‐OH‐VD3 was included during their differentiation: VD3‐‘tolerized’ moDC were less effective in their induction of T‐cell proliferation,20 but rather induced Treg cells that promoted transplant tolerance 21, 22.…”

Section: Insights From Culture Models Of DC Generation From Monocytesmentioning

confidence: 99%

Vitamin D immunoregulation through dendritic cells

2016

View full text Add to dashboard Cite

SummaryVitamin D (VD3) has been linked to immunological processes, and its supplementation may have a role in treatment or prevention of diseases with underlying autoimmune or pro‐inflammatory states. As initiators of the immune responses, dendritic cells (DC) are a potential target of VD3 to dampen autoimmunity and inflammation, but the role of DC in VD3‐mediated immunomodulation in vivo is not understood. In addition to being targets of VD3, DC can provide a local source of bioactive VD3 for regulation of T‐cell responses. Here we review existing studies that describe the tolerogenic potential of VD3 on DC, and discuss them in the context of current understanding of DC development and function. We speculate on mechanisms that might account for the potent but poorly understood tolerogenic activities of VD3 and the role of DC as both targets and sources of this hormone.

show abstract

“…Of paramount importance for the activating effect of 1,25-hydroxy vitamin D on various monocyte/ macrophage functions is the fact that macrophages not only express the VDR, but are also endowed with CYP27B1 activity [32]. Therefore, under conditions of low serum 25-hydroxy vitamin D levels, only limited 1,25-hydroxy vitamin D can be produced by macrophages from the precursor.…”

Section: Infectious Inflammatory and Autoimmune Diseasesmentioning

confidence: 99%

Role of Vitamin D in Various Illnesses: A Review

Tiwari¹,

Sharma²

2017

J Pharma Care Health Sys

View full text Add to dashboard Cite

Vitamin D, a fat-soluble vitamin, concentrations need to be maintained for functioning of the metabolic, immune, reproductive, muscular, skeletal, respiratory and cutaneous systems of men and women of all ages. A rough estimate indicates that about 1 billion people globally are vitamin D deficient. The physiological functions of active vitamin D (calcitriol) are related to calcium homeostasis and osteoporosis, with possible roles in diabetes, cancer, ischemic heart disease, and autoimmune and infectious diseases. Vitamin D deficit increases the risk of malignancies, particularly of colon, breast and prostate gland, of chronic inflammatory and autoimmune diseases (e.g. insulin-dependent diabetes mellitus, inflammatory bowel disease, multiple sclerosis), as well as of metabolic disorders (metabolic syndrome, hypertension). The eight disorders discussed in this review are heart disease, bone disorder, colorectal cancer and other malignancies, infectious, inflammatory and autoimmune diseases, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and type-I diabetes mellitus. There is a strong evidence for association between heart diseases, bone disorders, colorectal cancers, infectious, inflammatory and autoimmune diseases, inflammatory bowel diseases, multiple sclerosis, diabetes mellitus type-I and vitamin D. the extent of vitamin D deficiency's contribution in the development of osteoporosis, breast cancer, rheumatoid arthritis is unclear.

show abstract

Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase

Cited by 231 publications

References 98 publications

Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial

Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial

Vitamin D immunoregulation through dendritic cells

Role of Vitamin D in Various Illnesses: A Review

Contact Info

Product

Resources

About