Extrapyramidal system neurotoxicity

Dorman, David C.

doi:10.1016/b978-0-444-62627-1.00012-3

Cited by 10 publications

(6 citation statements)

References 190 publications

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“…Apart from the pyramidal motor system, there is an extrapyramidal neuronal pathway involving in movement control, which serves an essential role in maintaining posture and regulating involuntary motor functions in human brain (Dorman, 2015; Lee & Muzio, 2020). One of those pathways is the cortico‐basal ganglia thalamo‐cortical circuits, which originating from cortical motor and premotor areas, passing though portions of the basal ganglia and THA and then projecting back into the frontal cortical area of origin in a closed loop (Mittal et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation modulates cortical–subcortical connectivity in sensorimotor network

Chen

Fan

Wei

et al. 2021

Eur J of Neuroscience

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Repetitive transcranial magnetic stimulation (rTMS) holds the ability to modulate the connectivity within the stimulated network. However, whether and how the rTMS targeted over the primary motor cortex (M1) could affect the connectivity within the sensorimotor network (SMN) is not fully elucidated. Hence, in this study, we investigated the after‐effects of rTMS over left M1 at different frequencies on connectivity within SMN. Forty‐five healthy participants were recruited and randomly divided into three groups according to rTMS frequencies (high‐frequency [HF], 3 Hz; low‐frequency [LF], 1 Hz; and SHAM). Participants received 1‐Hz, 3‐Hz or sham stimulation and underwent two functional magnetic resonance imaging (fMRI) scanning sessions before and after rTMS intervention. Using resting‐state functional connectivity (FC) approach, we found that high‐ and low‐frequency rTMS had opposing effects on FC within the SMN, especially for connectivity with subcortical regions (i.e., putamen, thalamus and cerebellum). Specifically, the reductions in connectivity between cortical and subcortical regions within cortico‐basal ganglia thalamo‐cortical circuits and the cognitive loop of cerebellum, and increased connectivity between cortical and subdivisions within the sensorimotor loop of cerebellum were observed after high‐frequency rTMS intervention, whereas the thalamus and cognitive cerebellum subdivisions exhibited increased connectivity, and sensorimotor cerebellum subdivisions showed decreased connectivity with stimulated target after low‐frequency stimulation. Collectively, these findings demonstrated the alterations of connectivity within SMN after rTMS intervention at different frequencies and may help to understand the mechanisms of rTMS treatment for movement disorders associated with deficits in subcortical regions such as Parkinson's disease, Huntington's disease and Tourette's syndrome.

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Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation modulates cortical–subcortical connectivity in sensorimotor network

Chen

Fan

Wei

et al. 2021

Eur J of Neuroscience

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“…Exposure to excessive amount of manganese can result in manganese neurotoxicity, producing adverse effects most notably in the human extrapyramidal system [ 6 , 7 , 8 ]. Neurotoxicity can occur following high-dose oral, inhalation, or parenteral exposure to manganese.…”

Section: Introductionmentioning

confidence: 99%

The Role of Oxidative Stress in Manganese Neurotoxicity: A Literature Review Focused on Contributions Made by Professor Michael Aschner

Dorman

2023

Biomolecules

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This literature review focuses on the evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity. This review is not intended to be a systematic review of the relevant toxicologic literature. Instead, in keeping with the spirit of this special journal issue, this review highlights contributions made by Professor Michael Aschner’s laboratory in this field of study. Over the past two decades, his laboratory has made significant contributions to our scientific understanding of cellular responses that occur both in vitro and in vivo following manganese exposure. These studies have identified molecular targets of manganese toxicity and their respective roles in mitochondrial dysfunction, inflammation, and cytotoxicity. Other studies have focused on the critical role astrocytes play in manganese neurotoxicity. Recent studies from his laboratory have used C. elegans to discover new facets of manganese-induced neurotoxicity. Collectively, his body of work has dramatically advanced the field and presents broader implications beyond metal toxicology.

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“…Moreover, rotenone is highly lipophilic with the ability to cross the blood-brain barrier rapidly. Presently, researchers used rotenone as an experimental drug that produces mitochondrial dysfunction in animal models [11] .…”

Section: Introductionmentioning

confidence: 99%

The Possible Ameliorative Effect of Granulocyte Colony Stimulating Factor on Rotenone Induced Changes in the Retinal Photoreceptors of Rats: Histological and Immunohistochemical Study

Kandeel

Balaha

Estfanous

2020

Egyptian Journal of Histology

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Introduction:Rotenone is an odorless isoflavone used as an insecticide, and piscicide. It is a potent inhibitor of the mitochondrial respiratory chain complex I leading to oxidative stress that ends with cell death. Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein cytokine and a hematopoietic growth factor, produced by many cells. It promotes cell proliferation, survival, and mobilization. It also has anti-inflammatory and anti-apoptotic actions. Aim: This study aimed to investigate the ameliorative effect of G-CSF in a rat model of rotenone-induced retinal photoreceptors' changes. Materials and Methods: 25 male Wistar rats were used and were divided in to 3 groups; Control group; ROT group: by which rats received 30 mg/kg/day rotenone suspended in 0.25 ml 0.5% CMC orally beginning from 1st day of the experiment till 28 th day; and G-CSF group: which was the rotenone group rats that further treated with 50 μg/kg/day G-CSF in 0.1 ml 5% dextrose subcutaneous for 15 days beginning from the 29 th day till the 43rd day of the experiment. Results: H & E results of the ROT group showed outer & inner segments with extensive structural damage, nuclear fragmentation, besides karyorrhexis, and karyolysis, together with vacuolations of the synaptic region. Also, significant increase of caspase-3 while, decrease of N-cadherin immunohistochemical expression. The EM findings revealed extensive degenerative changes in the all segments of the photoreceptors besides significantly increased malondialdehyde levels. Conclusion: G-CSF can ameliorates rotenone-induced degenerative structural changes in rat's retinal photoreceptors. This was through its anti-apoptotic and anti-inflammatory actions. So, G-CSF is a promising neuroprotective drug for retinal diseases and/or injuries.

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Extrapyramidal system neurotoxicity

Cited by 10 publications

References 190 publications

Repetitive transcranial magnetic stimulation modulates cortical–subcortical connectivity in sensorimotor network

Repetitive transcranial magnetic stimulation modulates cortical–subcortical connectivity in sensorimotor network

The Role of Oxidative Stress in Manganese Neurotoxicity: A Literature Review Focused on Contributions Made by Professor Michael Aschner

The Possible Ameliorative Effect of Granulocyte Colony Stimulating Factor on Rotenone Induced Changes in the Retinal Photoreceptors of Rats: Histological and Immunohistochemical Study

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