Extrapulmonary Tuberculosis

Bruchfeld, Judith; Forsman, Lina Davies; Fröberg, Gabrielle; Niward, Katarina

doi:10.1007/978-3-030-66703-0_29

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…The active form develops in approximately 5 to 10% of individuals exposed to Mycobacterium tuberculosis (Mtb) [21,[24][25][26]. In addition to pulmonary TB, extra-pulmonary TB (EPTB) is a significant clinical concern, as it can affect various body parts after the initial spread of Mtb through the pulmonary draining lymphatic system [27]. Symptomatic EPTB occurs in about 15% of infected individuals [28] and can involve various sites such as the peritoneum, kidneys, bone marrow, spleen, pleural, meningeal, peritoneal membranes, skin, and genito-urinary tract.…”

Section: Tuberculosismentioning

confidence: 99%

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Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis

Cavalcante-Silva

Almeida

Andrade

et al. 2023

IJMS

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Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability and a microbial-killing machine comprised of enzymes, antimicrobial peptides, and reactive oxygen species. In the last two decades, a new neutrophil immune response, the neutrophil extracellular traps (NETs), has been intensely researched. NETs comprise DNA associated with histones, enzymes, and antimicrobial peptides. These structures are related to antimicrobial immune response and some immuno-pathogenesis mechanisms. This mini review highlights the role of NETs in tuberculosis and how they can be helpful as a diagnostic tool and/or therapeutic target.

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Section: Tuberculosismentioning

confidence: 99%

“…Extrapulmonary TB typically occurs following the spread of Mtb from the initial pulmonary infection to the lymphatic system [27,41]. Furthermore, the dissemination of Mtb also takes place via hematogenous spread, whereby Mtb enters the bloodstream and can be transported to distant organs and tissues [42].…”

Section: Tuberculosismentioning

confidence: 99%