Extrapulmonary tuberculosis: are statistical reports accurate?

Kulchavenya, Ekaterina

doi:10.1177/2049936114528173

Cited by 108 publications

(113 citation statements)

References 39 publications

(51 reference statements)

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“…1 Genitourinary TB is the third most common form of extrapulmonary TB after pleural TB and lymphatic TB in several countries, including Canada and the United States. 2,3 According to the Centers for Disease Control and Prevention, the number of TB cases reported and the case rate is decreasing, with a rate of 3 cases per 100 000 people in the United States in 2013. 7 Immunocompromised patients, particularly HIV patients, are more at risk of developing TB.…”

Section: Discussionmentioning

confidence: 99%

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Genitourinary tuberculosis in North America: A rare clinical entity

Sourial

Brimo²,

Horn³

et al. 2015

CUAJ

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Introduction: Although tuberculosis (TB) is the most common cause of mortality from infectious diseases worldwide, genitourinary TB in North America is rare. We review 3 cases of genitourinary TB diagnosed within the last 5 years. Cases: The first case is that of a 76-year-old African-Canadian woman who was referred for percutaneous nephrolithotomy of right lower pole renal stones. Although renal TB was suspected, her initial urinary TB culture was negative. On follow-up imaging, she developed bilateral ureteral thickening and ureteroscopic biopsy confirmed necrotizing granulomata. Repeat urine cultures were positive for M. tuberculosis. The second case is a 73-yearold Italian-Canadian woman who was referred for ureteroscopic biopsy of left thickened ureter to rule out urothelial carcinoma. Initial urine TB cultures were negative, despite biopsies confirming granulomatous inflammation. She was closely followed with urine cytologies and TB cultures. Repeat urine culture was positive for M. tuberculosis. Both patients were treated with a course of anti-tuberculous agents and indwelling ureteral stents to relieve ureteral obstruction. The third case is a 70-year-old Cree woman who was referred for percutaneous nephrolithotomy of a left "staghorn stone" in an atrophic left kidney. Thirty years earlier she had been treated for pulmonary TB in addition to ileocystoplasty for a "thimble" bladder. A computed tomography scan showed autonephrectomized left kidney. Her urine TB cultures were negative. She was placed on prophylactic antibiotics for her recurrent bacterial urinary tract infections. Conclusion: Genitourinary TB may present in various subtle ways, and the astute clinician must have a high index of suspicion for this disease in patients with atypical clinical and radiologic findings. In addition, TB urine cultures should be repeated when there is high index of suspicion.

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Section: Discussionmentioning

confidence: 99%

“…1 Genitourinary TB is the third most common form of extrapulmonary TB after pleural TB and lymphatic TB in North America. 2,3 Patients have non-specific symptoms and atypical presentations, which often lead to difficulty and delay in diagnosis. Urinalysis usually shows culture-negative pyuria and hematuria.…”

Section: Introductionmentioning

confidence: 99%

Genitourinary tuberculosis in North America: A rare clinical entity

Sourial

Brimo²,

Horn³

et al. 2015

CUAJ

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“…Mainly MTB attacks lungs and causes pulmonary tuberculosis however organism can infect every part of human body hence TB of any site other than lungs is termed as extra-pulmonary TB. Prevalence of Extra pulmonary TB ranges 19-30% in different in various studies 1,2 . Extra pulmonary TB is predominantly associated with cervical lymph nodes (CLN) presented by swollen glands usually at base and or sides of the neck 3 .…”

Section: Introductionmentioning

confidence: 99%

Role of Fine Needle Aspiration Cytology And Histopathology in Diagnosis of Cervical Lymph Node Tuberculosis

Rahman¹

2017

IOSR JDMS

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“…9,10 Infections of the genital tract (both sexually transmitted infections and uropathogens) are considered common causes of male fertility disorders, with a prevalence of 6-10%. 11 UTIs and asymptomatic bacteriuria are frequent in elderly patients and in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Urogenital tuberculosis: The cause of ineffective antibacterial therapy for urinary tract infections

Kulchavenya¹,

Cherednicenko²

2018

European Urology Supplements

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Background: Urogenital tuberculosis (UGTB) is one of the great imitators; it is commonly masked by urinary tract infections (UTIs). We aimed to estimate how many UGTB patients were among patients with a long history of UTIs. Material and Methods: A total of 244 patients with recurrent UTIs and suspected UGTB were enrolled in an open, noncomparative prospective study. Their urine and expressed prostate secretion or ejaculate were cultured (a total of 1446 samples), and 421 isolates with growth of ⩾10 4 colony-forming units (CFU)/ml were investigated for drug resistance. Typically, UGTB diagnosis is made by individual case. Results: All 244 patients had a long history of recurrent UTIs (on average, 7.9 ± 3.4 years); all received at least five courses of antibacterial therapy without good result. UGTB was diagnosed in 63 (25.8%), and in 41 of these (65.1%), there was comorbidity of UTI and UGTB. Of 1446 samples investigated, 421 (29.1%) were positive, and 1025 were negative. Escherichia coli was found in 57.3% of gram-negative microflora and in 29.0% only among all uropathogens. E. coli was resistant to amoxicillin/clavulanate in 51.5-57.1%, to cefotaxime in 50.0-52.0%, to gentamycin in 33.3-59.5%, to ciprofloxacin in 63.2-66.7%, to levofloxacin in 54.8-45.2%, and to nitrofurantoin in 23. 5-20.8% in 20155-20.8% in and 20165-20.8% in , respectively. If, in 2015 isolates of E. coli were susceptible to imipenem, in 2016, 7.1% of strains were resistant to this antibiotic. Level of drug-resistance was higher in 2016, excluding only levofloxacin and nitrofurantoin. Conclusions: Total prevalence of UGTB among UTI patients with poor results of antibacterial therapy was 25.8%. Comorbidity of UTI and UGTB was diagnosed in 65.1%.

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Extrapulmonary tuberculosis: are statistical reports accurate?

Cited by 108 publications

References 39 publications

Genitourinary tuberculosis in North America: A rare clinical entity

Genitourinary tuberculosis in North America: A rare clinical entity

Role of Fine Needle Aspiration Cytology And Histopathology in Diagnosis of Cervical Lymph Node Tuberculosis

Urogenital tuberculosis: The cause of ineffective antibacterial therapy for urinary tract infections

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