Extrapulmonary symptoms of patients with asthma treated in specialist pulmonary care

Salsman, Margot L.; Nordberg, Hannah O.; Wittchen, Hans‐Ulrich; Mühlig, Stephan; Riedel, Oliver; Ritz, Thomas

doi:10.1016/j.jpsychores.2021.110538

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…This may be due to the fact that asthma control and quality of life are associated with traits that are not or only partially treated by asthma-specific medication. 7,8,[11][12][13][14][15] Hence, an increasing number of studies stress the importance of a multidimensional assessment of these patients, allowing a more comprehensive approach including nonpharmacological interventions. [16][17][18][19][20][21][22] Indeed, treatment of multiple traits in patients with asthma, such as persistent tobacco smoking, hyperventilation, frequent exacerbations, overweight, decreased exercise tolerance, physical inactivity, severe fatigue, depressive mood, and severe dyspnea, do require (a combination of) nonpharmacological interventions.…”

Section: Impact Of Treatable Traits On Asthma Control and Quality Of ...mentioning

confidence: 99%

Impact of Treatable Traits on Asthma Control and Quality of Life

Janssen

Helvoort²,

Tjalma

et al. 2023

The Journal of Allergy and Clinical Immunology: In Practice

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Section: Impact Of Treatable Traits On Asthma Control and Quality Of ...mentioning

confidence: 99%

Impact of Treatable Traits on Asthma Control and Quality of Life

Janssen

Helvoort²,

Tjalma

et al. 2023

The Journal of Allergy and Clinical Immunology: In Practice

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“…It is well-recognized that extrapulmonary features contribute to disease burden and functional impairment in patients with chronic respiratory diseases (CRDs) [ 1 , 2 ]. Abnormalities in body weight and body composition are among the most prominent extrapulmonary manifestations occurring in this population, with both low muscle mass and obesity being frequently reported in patients with chronic obstructive pulmonary disease (COPD) [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Frequency and Functional Consequences of Low Appendicular Lean Mass and Sarcopenic Obesity in Patients with Asthma Referred for Pulmonary Rehabilitation

Meys¹,

Machado²,

Spruit³

et al. 2023

Obes Facts

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Introduction: One of the most prominent extrapulmonary manifestations in patients with chronic respiratory disease is changes in body weight and composition. However, the frequency and functional consequences of low appendicular lean mass (ALM) or sarcopenic obesity (SO) in patients with asthma are largely unknown. Therefore, the aim of the current study was to assess the frequency and functional consequences of low appendicular lean mass index (ALMI) and SO in patients with asthma. Methods: A retrospectively analyzed cross-sectional study was conducted in 687 patients with asthma (60% female, 58 ± 13 years, FEV1 76 ± 25% pred) referred for comprehensive pulmonary rehabilitation (PR). Body composition, pulmonary function, exercise capacity, quadriceps muscle function, and quality of life were assessed. Patients were classified as presenting low ALMI according to the 10th percentiles of age-sex-body mass index (BMI)-specific reference values and as having SO according to the diagnostic procedure proposed by the 2022 ESPEN/EASO consensus. In addition, clinical outcomes between patients with normal and low ALMI or with and without SO were compared. Results: The frequency of patients classified as low ALMI was 19%, whereas 45% of the patients were obese. Among the obese patients, 29% had SO. In patients with normal weight, those with low ALMI were younger and had worse pulmonary function, exercise capacity and quadriceps muscle function than those with normal ALMI (all p < 0.05). Overweight patients with low ALMI presented poorer pulmonary function and quadriceps muscle function (both strength and total work capacity). In obese class I patients, those with low ALMI showed lower quadriceps strength and maximal oxygen uptake acquired during cardiopulmonary exercise testing. Both male and female patients with SO showed lower quadriceps muscle function and reduced maximal exercise capacity compared to non-SO asthma patients. Conclusion: Approximately one in five asthma patients presented low ALM when age-sex-BMI-specific ALMI cutoffs were applied. Obesity is common among patients with asthma referred for PR. Among the obese patients, a significant proportion presented SO. Low ALM and SO were associated with worse functional outcomes.

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Psychological distress and symptom-related burnout in asthma during the COVID-19 pandemic

et al. 2023

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People with asthma may be particularly vulnerable to pandemic-related psychological distress, and research is needed to understand the impact of the coronavirus disease 19 (COVID-19) pandemic on their health and well-being. We sought to study the well-being of people with asthma relative to non-asthmatic controls during the COVID-19 pandemic. We also investigated asthma symptoms and COVID-19-related anxiety as potential mediators of distress. Participants completed self-report measures of psychological functioning, including anxiety, depression, stress, and burnout. Controlling for potential confounds, multiple-regression analyses examined differences in psychological health between people with and without asthma. Mediator analyses investigated the role of asthma symptoms and COVID-19-related anxiety in this relationship. 234 adults (111 with asthma, 123 without) participated in an online survey from July to November 2020. During this time, people with asthma reported higher levels of anxiety, perceived stress, and burnout symptoms compared to controls. Elevations in burnout symptoms were found beyond general anxiety and depression (sr2 = .03, p < .001). Reported symptoms typical in both asthma and COVID-19 partially mediated this relationship (Pm = .42, p < .05). People with asthma reported unique psychological challenges during the COVID-19 pandemic including elevated burnout symptoms. Experience of asthma symptoms played a key role in vulnerability to emotional exhaustion. Clinical implications include increased attention to asthma symptom burden within the context of heightened environmental stress and restricted healthcare access.

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Extrapulmonary symptoms of patients with asthma treated in specialist pulmonary care

Cited by 5 publications

References 40 publications

Impact of Treatable Traits on Asthma Control and Quality of Life

Impact of Treatable Traits on Asthma Control and Quality of Life

Frequency and Functional Consequences of Low Appendicular Lean Mass and Sarcopenic Obesity in Patients with Asthma Referred for Pulmonary Rehabilitation

Psychological distress and symptom-related burnout in asthma during the COVID-19 pandemic

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