Extrapulmonary small cell carcinoma of lymph node: Pooled analysis of all reported cases

Abstract

AIM:To study clinical outcomes and management of lymph nodes extrapulmonary small cell carcinoma (LNEPSCC). METHODS:Herein, we perform a systematic search of published literature in the PubMed and EMBASE databases for studies describing LNEPSCC. For uniformity of reporting, LNEPSCC was staged as limited if it involved either single lymph node station or if surgery with curative intent had been undertaken. The disease was staged extensive if it involved two or more lymph node regions. RESULTS:The systematic literature review yielded eight descriptions (n = 14) involving cervical, submandibular and inguinal lymph nodes. Eleven (64.7%) patients had limited disease (LD) and six (35.3%) had extensive disease (ED) at presentation. Chemotherapy (n = 6, 35.3%) or surgery (n = 4, 23.5%) were the most common form of treatment given to these patients. Complete response was achieved in 12 (70.6%) of the patients. Median (interquartile range) progression free survival and overall survival was 15 (7-42) mo and 22 (12.75-42) mo respectively. Of the three illustrative cases, two patients each had ED at presentation and achieved complete remission with platinum based combination chemotherapy.

Primary small cell carcinoma of the thyroid: a case report

“…Although EPSCC has histological similarity with small cell lung cancer and also a poor prognosis, some authors point some different outcomes in some cases, as the clinical and biological behaviour can vary with the site of origin and the extent of the cancer. 23 The disease arising in female genital tract and organ limited is associated with a better survival. 24 When a diagnosis of EPSCC arising in the head and neck region is made, the patient should be evaluated first to determine whether the disease is a primary or metastatic cancer.…”

Extrapulmonary small cell carcinoma. Literature review

“…Описаны также МРВЛ с локализацией в лимфоузлах. В литературе имеется менее 15 сообщений о таком варианте МРВЛ [64]. Авторы отмечают, что прогноз лучше, чем при МРЛ.…”