Extrapulmonary Small-cell Carcinoma: a Single-institution Experience

Kim, Jung Han; Lee, Se‐Hoon; Park, Jinny; Kim, Ho Young; Lee, Soon Il; Nam, Eun Mi; Park, Joon Oh; Kım, Kihyun; Jung, Chul Won; Im, Young Hyuck; Kang, Won Ki; Lee, Mark H.; Park, Keunchil

doi:10.1093/jjco/hyh052

Cited by 126 publications

(116 citation statements)

References 23 publications

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“…Pulmonary small-cell carcinoma prognosis is dismal and the outcomes regarding extra-pulmonary disease are equally poor, with 5-year survival rates of 11 to 13% (12)(13)(14)(15). Combined RT and ChT are considered to be the standard approach and surgery is reserved for limited stage initial and range from surgery to isolated or combined RT and ChT (9,10,17).…”

Section: Discussionmentioning

confidence: 99%

“…Combined RT and ChT are considered to be the standard approach and surgery is reserved for limited stage initial and range from surgery to isolated or combined RT and ChT (9,10,17). Interestingly, attempts have been tried to undergo curative-intent resections first, and the median survival for those who received surgical resection followed by adjuvant treatment was longer than those without resection (12)(13)(14)(18)(19)(20)(21)(22). However, no specific treatment guidelines are available due to the rarity of these tumors.…”

Section: Discussionmentioning

confidence: 99%

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Small-Cell Neuroendocrine Carcinoma Originating From the Nasopharynx: Report of a Rare Case

Aguiar

Jacóme

Azevedo

et al. 2015

Rep Radiother Oncol

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Introduction: Extrapulmonary small-cell carcinoma, neuroendocrine type is uncommon, particularly in the head and neck region. It represents an extremely rare finding when originating from the nasopharynx, and so far only five cases have been reported. Case Presentation: The authors present a case of a female patient with this tumor type, and describe a treatment strategy that combined radiotherapy and chemotherapy. Conclusions: Persistent disease was documented ten months after treatment completion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Small-Cell Neuroendocrine Carcinoma Originating From the Nasopharynx: Report of a Rare Case

Aguiar

Jacóme

Azevedo

et al. 2015

Rep Radiother Oncol

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“…Small cell carcinoma most commonly occurs in the lung, but can also in the extrapulmonary sites such as gastrointestinal or genitourinary tract, gynecological systems, the head and neck, and the breast (Haider et al, 2006;Galanis et al, 1997;Kim et al, 2004;Adegbola et al, 2005;Shin et al, 2000). Primary extrapulmonary small cell carcinomas are rare, and their behaviors are somewhat comparable to the small cells of the lung.…”

Section: Discussionmentioning

confidence: 99%

Breast metastasis from small cell lung carcinoma

Luh

Kuo

Tsao

2008

J. Zhejiang Univ. Sci. B

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Breast metastases from extramammary neoplasms are very rare. We presented a 66 year-old female with metastasis of small cell lung carcinoma to the breast. She presented with consolidation over the left upper lobe of her lung undetermined after endobronchial or video-assisted thoracoscopic surgery (VATS) biopsy, and this was treated effectively after antibiotic therapy at initial stage. The left breast lumps were noted 4 months later, and she underwent a modified radical mastectomy under the impression of primary breast carcinoma. However, the subsequent chest imaging revealed re-growing mass over the left mediastinum and hilum, and cells with the same morphological and staining features were found from specimens of transbronchial brushing and biopsy. An accurate diagnosis to distinguish a primary breast carcinoma from metastatic one is very important because the therapeutic planning and the outcome between them are different.

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“…Surgical resection by nephrectomy and systemic chemotherapy is the currently available therapeutic modality [7,9,16,29,30]. Nephrectomy helps to establish the correct diagnosis, i.e.…”

Section: Therapymentioning

confidence: 99%

“…Most patients die of the disease within a few years [7,8]. Distant metastasis occurs in the brain, bone, lung, liver and adrenal gland [2,3,6,8,16,17,20,30]. It is possible that patients with organ-confined tumor may have a long-term survival with early discovery and treatment [8].…”

Section: Prognosismentioning

confidence: 99%

Review of small cell carcinoma of the kidney with focus on clinical and pathobiological aspects

Imamura

Hamashima

Ohe

et al. 2014

pjp

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Small cell carcinoma (SmCC) of the kidney is extremely rare. In this article, we present a review of SmCC of the kidney with the focus on clinical and pathobiological aspects. Macroscopically, this tumor often shows a bulky mass extensively replacing the renal parenchyma with vascular invasion and metastasis to lymph nodes. Histologically, the tumor is composed of small cells with scant cytoplasm, round to oval nuclei, finely granular chromatin and inconspicuous nucleoli. Rosette or tubular formation may be present. Immunohistochemically, neoplastic cells show variable positivity for neuron-specific enolase, chromogranin A, synaptophysin, CD57 (Leu7) and CD56. A dot-like staining pattern for cytokeratin may also be observed. An electron microscopic examination may identify electron-dense neurosecretory granules in the cytoplasm. As a therapeutic option, nephrectomy and systemic chemotherapy should be considered. However, despite multimodal therapy, most patients have a dismal outcome and die of widely metastatic disease within one to two years. As there are limited genetic data on SmCC of the kidney, a large series studying this will be needed in the future.

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Extrapulmonary Small-cell Carcinoma: a Single-institution Experience

Abstract: EPSCC was identified in various sites, with the most common primary site being the uterine cervix. Regardless of the primary site or disease stage, EPSCC of sites other than cervix was usually a fatal disease with a discouraging outcome for various treatment modalities.

Cited by 126 publications

References 23 publications

Small-Cell Neuroendocrine Carcinoma Originating From the Nasopharynx: Report of a Rare Case

Small-Cell Neuroendocrine Carcinoma Originating From the Nasopharynx: Report of a Rare Case

Breast metastasis from small cell lung carcinoma

Review of small cell carcinoma of the kidney with focus on clinical and pathobiological aspects

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