Extrapulmonary small cell carcinoma: A single-institution experience and review of the literature

Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases

“…A small percentage of cases presented as a composite tumor ( n = 22; 5.0%) with features of both NCL and squamous cell carcinoma on histological examination. The vast majority of these patients had small‐cell neuroendocrine carcinoma ( n = 20; 90.9%) . The other 2 cases concerned an atypical and an unspecified carcinoid tumor …”

“…The literature on NCL is fragmented over numerous case reports and series of small sample size, often with contradicting results, making it difficult to decide on an appropriate treatment strategy. Consequently, physicians facing these tumors often resort to treatment paradigms developed for better known neoplasms (eg, squamous cell carcinoma).…”

Extrapulmonary small cell sarcinoma: involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans

“…Combination cisplatin and etoposide (EP) is a commonly used regimen for EPSCC with a response rates reported, in extensive disease, as 50% to 70%. It remains the cornerstone of therapy in SCLC [ 4 , 5 , 15 ]. In the first line setting single agent topotecan and paclitaxel have shown to be possible therapeutic options.…”

“…First described by Duguid and Kennedy in 1930 [ 1 , 2 ] EPSCC is recognized as a clinicopathologic entity distinct from small cell lung carcinoma [ 3 - 5 ]. Small cell carcinomas arising outside the lung have been reported in almost every organ of the body [ 5 - 7 ].…”

“…First described by Duguid and Kennedy in 1930 [ 1 , 2 ] EPSCC is recognized as a clinicopathologic entity distinct from small cell lung carcinoma [ 3 - 5 ]. Small cell carcinomas arising outside the lung have been reported in almost every organ of the body [ 5 - 7 ]. Primary locations include the head and neck, salivary glands, thyroid, larynx, trachea, thymus, pleura, esophagus, stomach, intestines, rectum, pancreas, gallbladder, cervix, uterus, breast, prostate, urinary bladder, and skin [ 8 ].…”