Extrapulmonary sarcoidosis of liver and pancreas: A case report and review of literature

Abstract

Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin, which can involve nearly all organs. In the case of an infrequent gastrointestinal tract involvement in systemic sarcoidosis, granulomas of the liver are most commonly described while isolated pancreatic sarcoid lesions are rarely seen. We report a case of systemic sarcoidosis with exclusive extrapulmonal involvement of the liver and the pancreas in a 71-yearold white man. The diagnosis of liver involvement was confirmed by biopsy. Pancreatic surgery was needed because preoperative evaluation could not exclude pancreatic cancer and for biliary decompression. An extensive literature review of systemic sarcoidosis, focusing on reported cases with unusual presentation of sarcoidosis in the liver and the pancreas, its diagnosis, treatment, and prognosis was made.

Long-Term Outcomes of Liver Transplantation for Hepatic Sarcoidosis: A Single Center Experience

“…17 About 10% of patients with sarcoidosis will have some form of abnormality in their transaminases or alkaline phosphatase and only about 1% will develop portal hypertension progressing to cirrhosis and liver failure. 18,19 In our group of patients with sarcoidosis, 23% had disease limited to liver only. In other studies, disease limited to liver has been reported in up to 47% of patients seen in a liver clinic.…”

Primary biliary sarcoidosis mimicking Klatskin tumor: case report and review of literature

“…However, this case highlights the fact that biliary sarcoidosis may exist in the absence of constitutional systemic symptoms, or indeed hepatic or pulmonary sarcoidosis (8). The treatment for biliary sarcoidosis is the same as for systemic sarcoidosis.…”

Diagnostic Dilemma of Sarcoidosis: A Case Report Masquerading as Tuberculosis

“…Portal hypertension with variceal bleeding, a hepatopulmonary syndrome with refractory hypoxemia, and cirrhosis leading to liver failure occur in only 1% of patients with sarcoidosis. 14 Most patients with pulmonary sarcoidosis do not require treatment. Asymptomatic CXR infiltrates are usually monitored.…”