Extrapulmonary oat‐cell carcinoma of the tongue: an electron‐microscopic study

Hull, Meredith T.; Eble, John N.; Warfel, K. A.

doi:10.1111/j.1600-0714.1984.tb01449.x

Cited by 21 publications

(11 citation statements)

References 25 publications

(13 reference statements)

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“…1,2,4 The most common site of extrapulmonary SCNC is the esophagus. 5,6 SCNC also arises primarily in the head and neck region, 3,[7][8][9][10][11] where it most commonly involves the larynx. 12 The purpose of this article is to give the reader an overview about this unusual tumor of the larynx.…”

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confidence: 99%

Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review

Ferlito

Rinaldo

2008

Head & Neck

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Primary laryngeal small cell neuroendocrine carcinoma (SCNC) is an unusual malignancy accounting for <0.5% of laryngeal carcinomas. To date, approximately 200 cases of primary and 5 of secondary SCNC of the larynx have been reported. This tumor most often presents in the sixth and seventh decades in men who are heavy cigarette smokers. The lesion may be associated with different paraneoplastic syndromes (ectopic adrenocorticotropic hormone syndrome, Schwartz-Bartter syndrome or syndrome of inappropriate secretion of antidiuretic hormone, and Eaton-Lambert myasthenic syndrome) or with ectopic hormone production. The diagnosis is based essentially on the histologic appearance of the tumor, confirmed by immunocytochemical investigations. Concurrent chemoradiotherapy regimens offer potential for long-term survival. This tumor is biologically aggressive, and the extent of the disease is the most significant independent prognostic factor of survival. The survival rate is similar to that with pulmonary SCNC.

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confidence: 99%

Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review

Ferlito

Rinaldo

2008

Head & Neck

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“…3). Such tumors may also occasionally arise within the oral mucosa (35–37). In these instances, a thorough clinical evaluation of the patient becomes necessary to exclude the possibility of a metastatic presentation of NEC.…”

Section: Neuroendocrine Tumors Of the Oral Mucosamentioning

confidence: 99%

Neuroendocrine cells and associated malignancies of the oral mucosa: a review

Mahomed

2010

Journal of Oral Pathology &Amp; Medicine

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Neuroendocrine cells of the oral mucosa constitute an under-recognized component of the diffuse neuroendocrine system with diverse subpopulations and elusive biologic roles in the oral cavity. Primary malignant oral tumors that show a neuroendocrine phenotype display histomorphologic heterogeneity thereby giving rise to a spectrum of lesions in this rare category of oral malignancy. These lesions can be divided into neuroendocrine carcinomas (NECs) of small cell or non-small cell type. The former is further subdivided into the Merkel cell type or the pulmonary type while the latter includes atypical carcinoid tumor and large cell NEC. All histologic subtypes of oral NEC appear to have a strong predilection for men in their fifth or sixth decade and arise predominantly in the non-keratinized oral mucosa. The biologic behavior of oral Merkel cell carcinomas appears to be more aggressive than those of skin. It remains to be determined whether histologic categorization of the remaining tumor subtypes is predictive of patient survival in oral neuroendocrine tumors.

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“…[2] The tongue is an extremely rare site for NECs with only seven cases reported in literature till date. [3456789] However, due to the paucity of studies, no definite prognostic factors and treatment protocols are defined for these tumors in the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

Postradiotherapy small cell neuroendocrine carcinoma of base of tongue

Jha

Sharma

Yadav

et al. 2017

Journal of Postgraduate Medicine

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Small cell neuroendocrine carcinoma (NEC) of the tongue is an extremely rare entity with only seven cases reported in literature till date. These are high-grade tumors with a dismal prognosis. There is much ambiguity regarding the classification, treatment protocols and prognostic factors of these tumors due to the paucity of studies. We describe an exceptionally rare and unusual case of small cell NEC of the base of tongue arising in an elderly man 6 years after receiving radiotherapy for the treatment of squamous cell carcinoma at the same site. The diagnosis was confirmed on histopathological examination and supported by immunohistochemical positivity for neuron-specific enolase, synaptophysin, chromogranin, pan-cytokeratin, and cytokeratin 7. To the best of our knowledge, this is the first case of intraoral NEC arising many years later within the irradiated field of the initial tumor.

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Extrapulmonary oat‐cell carcinoma of the tongue: an electron‐microscopic study

Cited by 21 publications

References 25 publications

Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review

Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review

Neuroendocrine cells and associated malignancies of the oral mucosa: a review

Postradiotherapy small cell neuroendocrine carcinoma of base of tongue

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