Extrapulmonary Manifestations of Sarcoidosis

Rao, Deepak A.; Dellaripa, Paul F.

doi:10.1016/j.rdc.2013.02.007

Cited by 112 publications

(137 citation statements)

References 111 publications

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“…Similar to adult, pediatric-onset adult sarcoidosis is a pulmonary disease in about 90% with extrapulmonary disease either concurrent or in the absence of lung/hilar involvement showing a variable frequency depending on the organ system [10,11]. About 1% of sarcoidosis begin at or before age 15 as shown in the Danish sarcoidosis registry [11].…”

Section: Systemic Granulomatous Disordersmentioning

confidence: 99%

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Granulomatous inflammation: The overlap of immune deficiency and inflammation

Rosé

Neven

Wouters

2014

Best Practice & Research Clinical Rheumatology

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Section: Systemic Granulomatous Disordersmentioning

confidence: 99%

“…The tendency to develop granulomatous inflammation can be seen in traumatic scars or tattoos as small papules around the scar. All these lesions are commonly observed simultaneously with hilar or lung disease, hence chest imaging is recommended when there is histological confirmation of granulomatous dermatitis [1,10].…”

Section: Systemic Granulomatous Disordersmentioning

confidence: 99%

Granulomatous inflammation: The overlap of immune deficiency and inflammation

Rosé

Neven

Wouters

2014

Best Practice & Research Clinical Rheumatology

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“…Recently, a new term "extensive" sarcoidosis has been used for systemic involvement of more than two organs except of involving of extrathoracical lymph nodes 7 . Extrapulmonary sarcoidosis may be on occasion life threatening and may also affect the therapeutic approach 9 . There is also evidence that patients with pulmonary plus extrapulmonary sarcoidosis are more impaired in the severity of symptoms, restrictions of activities of daily living and there is also impairment of health status comparing to the patients with isolated pulmonary sarcoidosis 10 .…”

Section: Introductionmentioning

confidence: 99%

Extrapulmonary involvement in patients with sarcoidosis and comparison of routine laboratory and clinical data to pulmonary involvement

Žůrková¹,

Kolek²,

Tománková³

et al. 2014

BIOMED PAP

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Introduction.Patients with pulmonary and pulmonary plus extrapulmonary sarcoidosis differ in symptom severity and health status impairment. To date there is no information on differences in clinical and laboratory parameters between these phenotypes and limited information on extrapulmonary involvement in Czech sarcoidosis patients exists. Methods. We therefore compared clinical data (age, gender, organ involvement, lung function tests) and laboratory data (blood counts, bronchoalveolar fluid (BAL) cellular profile, serum levels of CRP, SACE, sIL-2R, neopterin) between patients with newly diagnosed pulmonary sarcoidosis (n=107) and those with pulmonary plus extrapulmonary sarcoidosis (n=54). Results. Extrapulmonary sarcoidosis was diagnosed in 33% of patients, mostly affecting lymph nodes and skin and having hypercalciuria. There was no difference in the prevalence of extrapulmonary sarcoidosis between genders. Patients with extrapulmonary sarcoidosis were older and mostly non-smokers when compared to those with limited pulmonary form. X-ray Stage I and erythema nodosum were less frequent in extrapulmonary disease. Serum levels of CRP, SACE, sIL-2R and neopterin and BAL cellular profile did not differ between both phenotypes. We observed lower platelets, FEV1, VC, and BAL CD19+ in females with extrapulmonary involvement than in those with pulmonary disease. Conclusion. Affected lymph nodes, skin and hypercalciuria were the most common in sarcoidosis patients with extrapulmonary involvement. Pulmonary sarcoidosis did not differ in clinical and routine laboratory parameters from pulmonary plus extrapulmonary sarcoidosis. Observation of low platelets, VC, FEV1 and BAL CD19+ in females with extrapulmonary sarcoidosis needs further verification in larger cohort.

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“…Autopsy analyses show that myocardial granulomas can be found in 20% to 30% of patients [12]. In patients with documented pulmonary sarcoidosis and no previously diagnosed cardiac sarcoidosis, one third had abnormalities on cardiac MRI and up to 80% had metabolic abnormalities on PET scanning [13].…”

Section: Organ Involvementmentioning

confidence: 99%

Sarcoidosis: The Organs Involved. A Primer for Primary Care Physicians

Rissmiller¹

2017

Int Arch Intern Med

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Sarcoidosis is a granulomatous disease of unknown etiology that can affect any organ. Management of sarcoidosis patients with the potential for multi-organ involvement can be complex and require the expertise of multiple specialties. The goal of this review is to discuss clinical, imaging and epidemiologic features of organ involvement in sarcoidosis, treatment strategies, and which patients are appropriate for referral to a clinic dedicated to the management of patients with sarcoidosis.

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Extrapulmonary Manifestations of Sarcoidosis

Cited by 112 publications

References 111 publications

Granulomatous inflammation: The overlap of immune deficiency and inflammation

Granulomatous inflammation: The overlap of immune deficiency and inflammation

Extrapulmonary involvement in patients with sarcoidosis and comparison of routine laboratory and clinical data to pulmonary involvement

Sarcoidosis: The Organs Involved. A Primer for Primary Care Physicians

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