Extrapolating Contaminant Effects from Individuals to Populations: A Case Study on Nanoparticle Toxicity to Daphnia Fed Environmentally Relevant Food Levels

Stevenson, Louise; Krattenmaker, Katherine E.; McCauley, Edward; Nisbet, Roger M.

doi:10.1007/s00244-022-00950-7

Cited by 6 publications

(1 citation statement)

References 40 publications

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“…Stevenson et al. ( 2022 ) for example reported substantially higher levels of toxicity of Ag nanoparticles to Daphnia pulicaria when exposed under limited but environmentally relevant feeding conditions. Similarly, Campos et al.…”

Section: Introductionmentioning

confidence: 99%

Chronic toxicity of core–shell SiC/TiO ₂ (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid

Serwatowska,

Nederstigt,

Peijnenburg

et al. 2024

Nanotoxicology

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To date, research on the toxicity and potential environmental impacts of nanomaterials has predominantly focused on relatively simple and single-component materials, whilst more complex nanomaterials are currently entering commercial stages. The current study aimed to assess the long-term and size-dependent (60 and 500 nm) toxicity of a novel core–shell nanostructure consisting of a SiC core and TiO 2 shell (SiC/TiO 2 , 5, 25, and 50 mg L −1 ) to the common model organism Daphnia magna . These novel core–shell nanostructures can be categorized as advanced materials. Experiments were conducted under environmentally realistic feeding rations and in the presence of a range of concentrations of humic acid (0.5, 2, 5, and 10 mg L −1 TOC). The findings show that although effect concentrations of SiC/TiO 2 were several orders of magnitude lower than the current reported environmental concentrations of more abundantly used nanomaterials, humic acid can exacerbate the toxicity of SiC/TiO 2 by reducing aggregation and sedimentation rates. The EC 50 values (mean ± standard error) based on nominal SiC/TiO 2 concentrations for the 60 nm particles were 28.0 ± 11.5 mg L −1 (TOC 0.5 mg L −1 ), 21.1 ± 3.7 mg L −1 (TOC 2 mg L −1 ), 18.3 ± 5.4 mg L −1 (TOC 5 mg L −1 ), and 17.8 ± 2.4 mg L −1 (TOC 10 mg L −1 ). For the 500 nm particles, the EC50 values were 34.9 ± 16.5 mg L −1 (TOC 0.5 mg L −1 ), 24.8 ± 5.6 mg L −1 (TOC 2 mg L −1 ), 28.0 ± 10.0 mg L −1 (TOC 5 mg L −1 ), and 23.2 ± 4.1 mg L −1 (TOC 10 mg L −1 ). We argue that fate-driven phenomena are often neglected in effect assessments, whilst environmental factors such as the presence of humic acid may significantly influence the toxicity of nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Chronic toxicity of core–shell SiC/TiO ₂ (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid

Serwatowska,

Nederstigt,

Peijnenburg

et al. 2024

Nanotoxicology

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How Model Organisms and Model Uncertainty Impact Our Understanding of the Risk of Sublethal Impacts of Toxicants to Survival and Growth of Ecologically Relevant Species

Ivan,

Jones,

Albers

et al. 2024

Enviro Toxic and Chemistry

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Understanding how sublethal impacts of toxicants affect population‐relevant outcomes for organisms is challenging. We tested the hypotheses that the well‐known sublethal impacts of methylmercury (MeHg) and a polychlorinated biphenyl (PCB126) would have meaningful impacts on cohort growth and survival in yellow perch (Perca flavescens) and Atlantic killifish (Fundulus heteroclitus) populations, that inclusion of model uncertainty is important for understanding the sublethal impacts of toxicants, and that a model organism (zebrafish Danio rerio) is an appropriate substitute for ecologically relevant species (yellow perch, killifish). Our simulations showed that MeHg did not have meaningful impacts on growth or survival in a simulated environment except to increase survival and growth in low mercury exposures in yellow perch and killifish. For PCB126, the high level of exposure resulted in lower survival for killifish only. Uncertainty analyses increased the variability and lowered average survival estimates across all species and toxicants, providing a more conservative estimate of risk. We demonstrate that using a model organism instead of the species of interest does not necessarily give the same results, suggesting that using zebrafish as a surrogate for yellow perch and killifish may not be appropriate for predicting contaminant impacts on larval cohort growth and survival in ecologically relevant species. Our analysis also reinforces the notion that uncertainty analyses are necessary in any modeling assessment of the impacts of toxicants on a population because it provides a more conservative, and arguably realistic, estimate of impact. Environ Toxicol Chem 2024;00:1–12. © 2024 SETAC

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Models as Much Needed Tools in Ecotoxicology: Integrative Approaches to Cross Barriers

Desforges

Weijs

Hickie

et al. 2022

Arch Environ Contam Toxicol

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Extrapolating Contaminant Effects from Individuals to Populations: A Case Study on Nanoparticle Toxicity to Daphnia Fed Environmentally Relevant Food Levels

Cited by 6 publications

References 40 publications

Chronic toxicity of core–shell SiC/TiO ₂ (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid

Chronic toxicity of core–shell SiC/TiO ₂ (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid

How Model Organisms and Model Uncertainty Impact Our Understanding of the Risk of Sublethal Impacts of Toxicants to Survival and Growth of Ecologically Relevant Species

Models as Much Needed Tools in Ecotoxicology: Integrative Approaches to Cross Barriers

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Extrapolating Contaminant Effects from Individuals to Populations: A Case Study on Nanoparticle Toxicity to Daphnia Fed Environmentally Relevant Food Levels

Cited by 6 publications

References 40 publications

Chronic toxicity of core–shell SiC/TiO 2 (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid

Chronic toxicity of core–shell SiC/TiO 2 (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid

How Model Organisms and Model Uncertainty Impact Our Understanding of the Risk of Sublethal Impacts of Toxicants to Survival and Growth of Ecologically Relevant Species

Models as Much Needed Tools in Ecotoxicology: Integrative Approaches to Cross Barriers

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Product

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Chronic toxicity of core–shell SiC/TiO ₂ (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid

Chronic toxicity of core–shell SiC/TiO ₂ (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid