Extrapituitary expression of the rat V1b vasopressin receptor gene.

Lolait, Stephen J.; O’Carroll, Anne-Marie; Mahan, Lawrence C.; Felder, Christian C.; Button, D; Young, W. Scott; Mezey, Éva; Brownstein, M. J.

doi:10.1073/pnas.92.15.6783

Cited by 301 publications

(188 citation statements)

References 26 publications

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“…The behavioral experiments showed that local infusion of SSR149415 in the lateral septal area induced clearcut and dose-dependent antidepressant-like effects in the forced-swimming test, while similar treatment did not modify anxiety-related behaviors in the punished drinking and elevated plus-maze tests. To date only a few studies have examined the expression of V 1b receptor mRNA or protein in the rat brain (Lolait et al, 1995;Vaccari et al, 1998;Hernando et al, 2001). Using RT-PCR, Lolait et al (1995) provided the first evidence of extrapituitary V 1b receptor mRNA expression in the rat brain tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Using anti-V 1b receptor immunohistochemistry, the presence of V 1b receptors was demonstrated in various regions of the rat brain (Hernando et al, 2001), including the olfactory system, the basal forebrain and basal ganglia, the hippocampal formation, some amygdaloid, thalamic, and hypothalamic nuclei, some cortical areas, and the cerebellum. Although V 1b mRNAs were previously located in the rat septal area using RT-PCR (Lolait et al, 1995), data concerning the localization of the protein in the lateral septum using selective anti-V 1b R antibody are still lacking. In this context, the first objective of the present work was to study the immunohistochemical localization of V 1b receptors in the rat brain using a new and specific anti-V 1b R antibody.…”

Section: Introductionmentioning

confidence: 99%

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Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415

Stemmelin

Lukovic

Salomé

et al. 2004

Neuropsychopharmacol

104

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Previous experiments with the first selective nonpeptide vasopressin V 1b receptor antagonist SSR149415 ((2S, 4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide) have shown that the drug elicits anxiolytic-and antidepressant-like effects following systemic administration. Extrahypothalamic V 1b receptors have been suggested to be involved in these effects as evidenced by the findings that hypophysectomized rats were still sensitive to the antistress action of SSR149415. The first objective of the present work aimed at locating V 1b receptors in the rat limbic brain using anti-V 1b receptor immunohistochemistry. The immunolabeling revealed high densities of V 1b receptors in the lateral septum, the amygdala, the bed nucleus of the stria terminalis, the hippocampal formation, and in several cortical areas. Since the lateral septum is well known to participate in the modulation of emotional processes, the second objective of this study went on to evaluate the behavioral effects of an infusion of SSR149415 into the lateral septum and to determine whether its behavioral effects are mediated by this structure. Animals were tested in models classically used for the screening of anxiolytics (ie the punished drinking and elevated plusmaze tests) and antidepressants (ie the forced-swimming test). Bilateral intraseptal infusion of SSR149415 (10 and 100 ng) produced a decrease in immobility time in the forced-swimming test, indicating antidepressant-like effects. In contrast, the behavior of rats in the punished drinking procedure or in the elevated plus-maze test was not modified by intraseptal infusion of SSR149415. These findings suggest that V 1b receptors located in the lateral septum participate in the antidepressant-but not the anxiolytic-like action of SSR149415 in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415

Stemmelin

Lukovic

Salomé

et al. 2004

Neuropsychopharmacol

104

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“…In these latter regions, arginine vasopressin exerts a neuromodulatory role via an action on specific receptors, i.e. V 1a and V 1b (Lolait et al, 1995;Vaccari et al, 1998;Young et al, 1999), which are widely distributed in the central nervous system (Lolait et al, 1995;Morel et al, 1992). Several findings suggest that arginine vasopressin may be involved in the modulation of emotional processes primarily via the V 1b receptor subtype.…”

Section: Effect Of the Arginine Vasopressin V 1b Receptor Antagonist mentioning

confidence: 99%

The Mouse Defense Test Battery: pharmacological and behavioral assays for anxiety and panic

Blanchard

Griebel

Blanchard

2003

European Journal of Pharmacology

256

159

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The Mouse Defense Test Battery was developed from tests of defensive behaviors in rats, reflecting earlier studies of both acute and chronic responses of laboratory and wild rodents to threatening stimuli and situations. It measures flight, freezing, defensive threat and attack, and risk assessment in response to an unconditioned predator stimulus, as well as pretest activity and postthreat (conditioned) defensiveness to the test context. Factor analyses of these indicate four factors relating to cognitive and emotional aspects of defense, flight, and defensiveness to the test context. In the Mouse Defense Test Battery, GABA A -benzodiazepine anxiolytics produce consistent reductions in defensive threat/attack and risk assessment, while panicolytic and panicogenic drugs selectively reduce and enhance, respectively, flight. Effects of GABA A -benzodiazepine, serotonin, and neuropeptide ligands in the Mouse Defense Test Battery are reviewed. This review suggests that the Mouse Defense Test Battery is a sensitive and appropriate tool for preclinical evaluation of drugs potentially effective against defense-related disorders such as anxiety and panic. D

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“…Moreover, it has been reported that a selective V1bR antagonist produced anxiolytic-and antidepressantlike effects in rodents Serradeil-Le Gal et al, 2002) and reversed stress-induced suppression of neurogenesis in a mouse model of depression (Alonso et al, 2004). V1bR is widely distributed in the central nervous system including the cerebral cortex, hippocampus, and hypothalamus (Lolait et al, 1995;Vaccari et al, 1998), suggesting that V1bR regulates the HPA system and plays a potential role in stress-related behavior.…”

Section: Introductionmentioning

confidence: 99%

Disruption of the Prepulse Inhibition of the Startle Reflex in Vasopressin V1b Receptor Knockout Mice: Reversal by Antipsychotic Drugs

Egashira

Tanoue

Higashihara

et al. 2005

Neuropsychopharmacol

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In the present study, we investigated whether mice lacking the arginine vasopressin (AVP) V1b receptor (V1bR) exhibit deficits of prepulse inhibition (PPI) of the startle reflex, reminiscent of the sensorimotor gating deficits observed in a large majority of schizophrenic patients. V1bR knockout (KO) mice displayed significantly reduced levels of PPI of the startle reflex. In addition to PPI deficits, V1bR KO mice showed increased acoustic startle response. However, acoustic startle response was not significantly correlated to the PPI of the startle reflex in V1bR KO mice. V1bR KO mice also showed a decrease in basal levels of extracellular dopamine (DA) in the medial prefrontal cortex, which is thought to be an important brain region for PPI. Moreover, PPI deficits observed in the V1bR KO mice are significantly reversed by atypical antipsychotics such as risperidone and clozapine but not by a typical neuroleptic haloperidol, like in schizophrenic patients. By contrast, we did not observe any significant differences between V1bR KO mice and wild-type mice in the open-field, light/dark, elevated plus maze, and forced swimming tests. The results of the present study indicate that V1bR may be involved in the regulation of PPI of the startle reflex. The V1bR has been considered an important molecular target for the development of antipsychotic drugs.

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Extrapituitary expression of the rat V1b vasopressin receptor gene.

Cited by 301 publications

References 26 publications

Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415

Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415

The Mouse Defense Test Battery: pharmacological and behavioral assays for anxiety and panic

Disruption of the Prepulse Inhibition of the Startle Reflex in Vasopressin V1b Receptor Knockout Mice: Reversal by Antipsychotic Drugs

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