Extraosseous Findings on Bone Scintigraphy Using Fusion SPECT/CT and Correlative Imaging

Wale, Daniel J.; Wong, Ka Kit; Savas, Hatice; Kandathil, Asha; Piert, Morand; Brown, Richard K.

doi:10.2214/ajr.14.13914

Cited by 39 publications

(40 citation statements)

References 48 publications

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“…However, because most patients that underwent bone scintigraphy had a history of cancer or suspected tumors, the population enrolled in this study was biased to a certain extent, which might have resulted in a higher proportion of malignant tumors. Previous studies suggested that the mechanisms of the neoplastic uptake of MDP were mainly related to necrosis and/or calcification, a rich blood supply and the osteoid matrix in tumors, 9 which was also supported by our study based on the findings of CT, MRI, ultrasound etc. : 28 (28/33, 84.8%) pediatric and 22 (22/31, 71.0%) adult tumors had varying degrees of necrosis and/or calcification in the lesions.…”

Section: Discussionsupporting

confidence: 90%

“…Otherwise, MDP uptake was mostly found in lung cancer (11/31, 35.5%) in adults, followed by liver metastases from the gastrointestinal tract and breast (9/31, 29.0%), which was basically consistent with previous reports. 9 Our study also confirmed that the extraosseous soft tissue tumors that accumulated MDP were likely to be malignant. Altogether, neoplastic uptake was observed in 63 pediatric (32/33) and adult (31/31) malignant tumors, with the exception of one pediatric benign vascular tumor.…”

Section: Discussionsupporting

confidence: 82%

“…The involved organs or tissues also included the brain, chest wall, lymph node, adrenal gland and peritoneum, which was consistent with previous reports. 9 However, in regard to MDP uptake, more adenocarcinoma than squamous cell carcinoma displayed MDP uptake in our patient sample (74.2% VS 22.6%), and the degree of MDP uptake in adenocarcinoma, which is characterized by a rich blood supply and a mucinous component that is able to accumulate calcium salts, was higher than that in squamous cell carcinoma in adults that had no obvious calcifications but had necrosis.…”

Section: Discussioncontrasting

confidence: 57%

“…These kinds of adenocarcinomas, which have a mucinous component, possess a glycoprotein that is biochemically similar to ossifying cartilage that binds calcium salts, which accumulate MDP. 9,[11][12][13] Lymph node metastases or hepatic metastases of these types of tumors easily bind calcium salts, which manifest as tiny, grit-like calcifications on CT, showing a lower degree of MDP uptake. The highest MDP uptake was found in an adult with thyroid follicular adenocarcinoma, which showed numerous irregular calcifications and high calcium density on CT images.…”

Section: Discussionmentioning

confidence: 99%

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99mTc-Methylene Diphosphonate Uptake in Soft Tissue Tumors on Bone Scintigraphy Differs Between Pediatric and Adult Patients and Is Correlated with Tumor Differentiation

Liu

Xie

et al. 2020

CMAR

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Objective: To analyze the difference in 99m Tc-methylene diphosphonate (MDP) uptake on bone scintigraphy in extraosseous soft tissue tumors between children and adults and the correlation between tracer uptake and tumor differentiation and histopathology. Methods: Patients with neoplasms with MDP uptake were retrospectively identified. Based on histopathology, tumors were categorized as epithelial malignant tumors, mesenchymal tumors, blastomas and germ cell tumors. The degree of radioactivity accumulation in lesions relative to the uptake in ribs and sternum or spine was classified as "+", "++" and "+++". The results were compared between children and adults. The correlations between MDP uptake in soft tumors and tumor differentiation and pathology were investigated. Results: Extraosseous soft tissue tumors that accumulated MDP were found in 33 children and 31 adults. In children, neuroblastoma was the most common extraosseous soft tissue tumor that accumulated MDP; in adults, MDP uptake was mostly found in lung cancer. MDP uptake in pediatric soft tissue tumors was higher than that in adults. MDP uptake in extraosseous soft tissue tumors with different histopathologic classifications was significantly different among 64 patients. In 41 patients with available tumor differentiation data from histopathology, MDP uptake in low or poorly differentiated soft tumors was higher than that in the moderately or well-differentiated lesions. Necrosis and/or calcifications were showed in most of pediatric and adult neoplasms. Conclusion: Significant elevations in MDP uptake in extraosseous soft tissue tumors are associated with poorly differentiated tumors in both children and adults. The mechanism of bone tracer uptake in pediatric and adult neoplasms was mostly related to necrosis and/or necrosis and calcification. The extraosseous soft tissue tumors with MDP uptake in pediatric patients were different from those in adults. In addition, consistent with the inherent degree of tumor malignancy, MDP uptake in children was higher than that in adults.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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99mTc-Methylene Diphosphonate Uptake in Soft Tissue Tumors on Bone Scintigraphy Differs Between Pediatric and Adult Patients and Is Correlated with Tumor Differentiation

Liu

Xie

et al. 2020

CMAR

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“…Palavras-chave: acidente vascular cerebral, cintilografia óssea, captação extra óssea. 1 Universidad CES. ORCID: 0000-0002-4373-3787.…”

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Accidente cerebro vascular visualizado en gammagrafía con Tc-99m MDP, un hallazgo extraóseo inusual

Yepes

Ramírez

Cubides

et al. 2019

AnFaMe

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Heterotopic Ossification: A Comprehensive Review

et al. 2019

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Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery. This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic features of HO, including nongenetic and genetic forms. First, the clinical features, radiographic appearance, histopathologic diagnosis, and current methods of treatment are discussed. Next, current concepts regarding the mechanistic bases for HO are discussed, including the putative cell types responsible for HO formation, the inflammatory milieu and other prerequisite “niche” factors for HO initiation and propagation, and currently available animal models for the study of HO of this common and potentially devastating condition. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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Extraosseous Findings on Bone Scintigraphy Using Fusion SPECT/CT and Correlative Imaging

Abstract: We present examples of extraosseous radiotracer uptake seen on (99m)Tc-MDP bone scans in which either SPECT with integrated CT or correlative imaging improved the study's interpretation.

Cited by 39 publications

References 48 publications

<p><sup>99m</sup>Tc-Methylene Diphosphonate Uptake in Soft Tissue Tumors on Bone Scintigraphy Differs Between Pediatric and Adult Patients and Is Correlated with Tumor Differentiation</p>

<p><sup>99m</sup>Tc-Methylene Diphosphonate Uptake in Soft Tissue Tumors on Bone Scintigraphy Differs Between Pediatric and Adult Patients and Is Correlated with Tumor Differentiation</p>

Accidente cerebro vascular visualizado en gammagrafía con Tc-99m MDP, un hallazgo extraóseo inusual

Heterotopic Ossification: A Comprehensive Review

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