Extraocular muscles in Graves ophthalmopathy: usefulness of T2 relaxation time measurements.

Abstract

T2 relaxation time measurements with MR allow noninvasive detection of acute muscle inflammation and predict which patients with GO will likely benefit from antiinflammatory therapy.

Orbital magnetic resonance imaging combined with clinical activity score can improve the sensitivity of detection of disease activity and prediction of response to immunosuppressive therapy for Graves' ophthalmopathy

“…AreaSUM was obtained on coronal sections by orbital MR imaging. The area of the rectus muscle on coronal section nosuppressive therapy [4][5][6][7].…”

“…Orbital MR imaging parameters of normal subjects, obtained from normal subjects, were as shown in Table 2 [6]. Orbital MR imaging was performed with a 0.5-T superconducting MR imaging system (FLEX ART; Toshiba, Tokyo, Japan).…”

“…In this respect, the correlation between CAS and orbital MR imaging parameters is vital, but reports about the correlation between CAS and MR imaging parameters are limited [12,14,16]. The edematous change of the orbital tissue increases CAS, and prolongs T2RT of EOMs [2,6,15,17]. This change was caused by the inflammation of orbital tissue and the high pressure in the orbit due to swollen orbital tissue.…”

High-Resolution Microscopy Coil MR-Eye

“…Surface coils of various configurations and sizes have been used in the past. [2][3][4][5][6][7] However, to the best of our knowledge, this is the first report on HR-MRI presenting such a detailed depiction of orbital structures with special reference to globe layers, Tenon's capsule and tarsal plates. The advantages of this technique, in particular, are that it does not require customised coils or long and elaborate acquisition procedures.…”

Thyroid Stimulating Antibody in Sera of Graves' Ophthalmopathy Patients as a Possible Marker for Predicting the Efficacy of Methylprednisolone Pulse Therapy.

“…It is obvious that the recent advent of MRI has permitted the assessment of fine and subtle changes in ocular muscle swelling in GO patients [29,30]. A recent study has shown the usefulness of T2 relaxation time measurements with MRI in GO patients for the prediction of systemic corticosteroids and retroorbital radiation therapy [31,32], suggesting further useful investigation which will be performed in a future study.…”