Extranodal Ocular Adnexal Marginal Zone Lymphoma in a Ten-Year-Old Child

Çetingül, Nazan; Palamar, Melis; Hacıkara, Şükriye; Kamer, Serra; Özdemir, Hamiyet Hekimci; Ataseven, Eda; Selver, Özlem Barut; Hekımgıl, Mıne

doi:10.4274/tjo.galenos.2019.62592

Cited by 4 publications

(1 citation statement)

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“…The incidence and prevalence of cancer are rising among older populations, especially in developed countries, and most cancers (> 80%) are found in the patients over 50 [11][12]. Most POAL patients are middle-aged and elderly, and the average age at diagnosis is around 60 years [13]. Currently, elderly cancer patients are often underrepresented in many clinical trials [14].…”

Section: Introductionmentioning

confidence: 99%

Nomograms for Predicting the Overall and Cause-Special Survival of Elderly Patients with Primary Ocular Adnexal Lymphoma

Cai

et al. 2023

Preprint

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Background: The goal of our study was to construct and validate nomograms for the prognosis of elderly primary ocular adnexal lymphoma (POAL) patients from the Surveillance, Epidemiology, and End Results Program (SEER) database. Methods: We screened the data of POAL patients aged 60 years or older from the SEER database from 2010 to 2015. For the prediction of the cause-special survival (CSS) and the overall survival (OS) at 1, 3, and 5 years in elderly POAL patients, we constructed nomograms. The nomograms were validated by the decision curve analysis (DCA), the area under the curve (AUC), and the calibration curve. Results: Among 821 enrolled POAL patients from the SEER database, 547 were assigned to the training group and 247 to the validation group. The C-index of the two groups was 0.744 and 0.755 in the OS model, 0.745 and 0.855 in the CSS model. The AUC values of the nomograms for OS were 0.819, 0.785, and 0.767 in the training cohorts and 0.872, 0.789, and 0.755in the validation cohorts at 1, 3, and 5 years, respectively. The AUC values of predicted CSS in the training and validation cohorts at 1, 3, and 5 years were 0.754, 0.772, 0.765 and 0.840, 0.864, 0.791, respectively. The calibration and DCA curves also demonstrated the predictive performances. Conclusions: Herein, for predicting the CSS and OS in elderly POAL patients, we constructed predictive nomograms using independent risk factors. These nomograms can help clinicians in predicting the prognosis of elderly POAL patients.

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Section: Introductionmentioning

confidence: 99%

Nomograms for Predicting the Overall and Cause-Special Survival of Elderly Patients with Primary Ocular Adnexal Lymphoma

Cai

et al. 2023

Preprint

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Conjunctiva

Yanoff,

Sassani

2025

Ocular Pathology

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Conjunctival Lymphoma

McGrath

Ryan

Warrier

et al. 2022

Eye

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Lymphoma of the conjunctiva is an ocular malignancy derived from clonal proliferation of lymphocytes. The majority of conjunctival lymphoma is extranodal marginal zone B-Cell lymphoma (EMZL), however diffuse large B-cell (DLBCL), follicular (FL), mantle cell (MCL) and T- cell subtypes are also seen. Clinical manifestations are non-specific, but include unilateral or bilateral painless salmon-pink conjunctival lesions. Approaches to treatment have centered around local immunomodulation, often with Interferon-α2b or Rituximab (anti-CD20 monoclonal antibody) with or without radiation. Although conjunctival lymphoma is generally considered an indolent disease, recent advances in next-generation sequencing have improved clinicians’ ability to predict future recurrence or systemic disease through assessment of cytogenic and molecular features. In this paper, we review the classification, clinical features, diagnostic techniques, and emerging strategies for management and prognostication of conjunctival lymphomas.

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Extranodal Ocular Adnexal Marginal Zone Lymphoma in a Ten-Year-Old Child

Abstract: A 10-year-old girl presented to the ophthalmology department with a fast-growing salmon-colored mass protruding from the medial aspect of the right lower eyelid for approximately 1 month (Figure 1A). The orbital lesion was also demonstrated on magnetic resonance imaging (MRI) (Figure 1B

Cited by 4 publications

References 11 publications

Nomograms for Predicting the Overall and Cause-Special Survival of Elderly Patients with Primary Ocular Adnexal Lymphoma

Nomograms for Predicting the Overall and Cause-Special Survival of Elderly Patients with Primary Ocular Adnexal Lymphoma

Conjunctiva

Conjunctival Lymphoma

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