Extranodal NK/T-cell lymphoma, nasal type

Al-Hakeem, Dalal Abdullah; Fedele, Stefano; Carlos, Román; Porter, Stephen

doi:10.1016/j.oraloncology.2006.03.011

Cited by 108 publications

(63 citation statements)

References 130 publications

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“…It commonly presents in adult men, especially in Asia and Central America, but there are infrequent reports of cases in Europe and the USA [17]. Seventy to ninety percent of ENKTCLs originate in the nasopharynx, although disseminated and extranasal disease also occurs [2, 3, 12, 18], as it did in our patient. This malignancy is characterized by an aggressive angiodestructive growth pattern and tumor necrosis [18] as well as a pathogenic link to EBV [19-22].…”

Section: Discussionsupporting

confidence: 56%

“…The prognosis of ENKTCL is poor, with a 5-year cumulative survival ranging from 37.9 to 45.5% and a median survival approximated at 12.5 months [2, 10, 12, 18]. While early stages may respond to radiation therapy, most patients present late and will fail multimodal treatment with chemotherapy and adjuvant radiation [2, 5, 7, 8, 10, 13].…”

Section: Discussionmentioning

confidence: 99%

“…While early stages may respond to radiation therapy, most patients present late and will fail multimodal treatment with chemotherapy and adjuvant radiation [2, 5, 7, 8, 10, 13]. Orbital/ocular adnexal involvement may portend an even worse outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type is a rare but aggressive malignant neoplasm that typically arises in the paranasal sinuses or nasal cavity [1], but has also been documented in the skin and soft tissue, upper respiratory and gastrointestinal tracts, and testes [2]. Like other non-Hodgkin lymphomas, it can masquerade as an intraocular inflammatory or infectious process [3], which can lead to delayed diagnosis and vision loss.…”

Section: Introductionmentioning

confidence: 99%

“…Like other non-Hodgkin lymphomas, it can masquerade as an intraocular inflammatory or infectious process [3], which can lead to delayed diagnosis and vision loss. The prognosis for ENKTCL is substantially worse than that of other T-cell or B-cell lymphomas [4], especially if patients present late or if there is orbital or ocular adnexal involvement [2, 5]. Early diagnosis is thus of utmost importance, but can prove quite challenging.…”

Section: Introductionmentioning

confidence: 99%

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Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

McCall

Proia

2018

Ocul Oncol Pathol

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Purpose: To report a case of extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type metastatic to the space beneath the retinal pigment epithelium (RPE) with coincident paraneoplastic lymphoma-associated retinopathy. Methods: Findings of clinical and histopathologic examination are presented with differential diagnoses and a literature review. Case Report: A 53-year-old man presented with bilateral blindness and had exudative retinal detachments overlying subretinal masses in both eyes. Flow cytometry of pericardial fluid revealed malignant T lymphocytes. After two cycles of chemotherapy, the patient was hospitalized and quickly expired. Autopsy revealed lymphoma involving the eyes, heart, right lung, and two subcarinal lymph nodes focally. Histopathologic examination of the eyes revealed intraocular metastases from ENKTCL, nasal type. Expression of CD3 and CD56, along with expression of Epstein-Barr virus by in situ hybridization, confirmed the diagnosis. Lymphomatous infiltrates were confined to the space beneath the neurosensory retina and between the RPE and the Bruch membrane, sparing the uveal tissue, similar to other metastatic T-cell lymphomas. Extensive RPE and photoreceptor loss in regions with and without underlying tumor was typical of a concurrent paraneoplastic lymphoma-associated retinopathy. Conclusion: Patients diagnosed with ENKTCL should be evaluated by an ophthalmologist, as ophthalmic involvement portends a poor prognosis.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

McCall

Proia

2018

Ocul Oncol Pathol

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Reactive Lymphadenopathy with Paracortical Pattern, Noninfectious Etiology

Bowers¹

2012

Non‐Neoplastic Hematopathology and Infections

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Extranodal NK/T-cell lymphoma, nasal type

Cited by 108 publications

References 130 publications

Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

Reactive Lymphadenopathy with Paracortical Pattern, Noninfectious Etiology

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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